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Genetic mutation and tumor microbiota determine heterogenicity of tumor immune signature: Evidence from gastric and colorectal synchronous cancers

Both colorectal and gastric cancer are lethal solid-tumor malignancies, leading to the majority of cancer-associated deaths worldwide. Although colorectal cancer (CRC) and gastric cancer (GC) share many similarities, the prognosis and drug response of CRC and GC are different. However, determinants...

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Autores principales: Yang, Weili, Zhao, Yaxing, Ge, Qiongxiang, Wang, Xiaoli, Jing, Yang, Zhao, Jingwen, Liu, Gang, Huang, He, Cheng, Fei, Wang, Xiaoxi, Ye, Yulin, Song, Wenjing, Liu, Xinjuan, Du, Juan, Sheng, Jianpeng, Cao, Xiaocang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676241/
https://www.ncbi.nlm.nih.gov/pubmed/36420271
http://dx.doi.org/10.3389/fimmu.2022.947080
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author Yang, Weili
Zhao, Yaxing
Ge, Qiongxiang
Wang, Xiaoli
Jing, Yang
Zhao, Jingwen
Liu, Gang
Huang, He
Cheng, Fei
Wang, Xiaoxi
Ye, Yulin
Song, Wenjing
Liu, Xinjuan
Du, Juan
Sheng, Jianpeng
Cao, Xiaocang
author_facet Yang, Weili
Zhao, Yaxing
Ge, Qiongxiang
Wang, Xiaoli
Jing, Yang
Zhao, Jingwen
Liu, Gang
Huang, He
Cheng, Fei
Wang, Xiaoxi
Ye, Yulin
Song, Wenjing
Liu, Xinjuan
Du, Juan
Sheng, Jianpeng
Cao, Xiaocang
author_sort Yang, Weili
collection PubMed
description Both colorectal and gastric cancer are lethal solid-tumor malignancies, leading to the majority of cancer-associated deaths worldwide. Although colorectal cancer (CRC) and gastric cancer (GC) share many similarities, the prognosis and drug response of CRC and GC are different. However, determinants for such differences have not been elucidated. To avoid genetic background variance, we performed multi-omics analysis, including single-cell RNA sequencing, whole-exome sequencing, and microbiome sequencing, to dissect the tumor immune signature of synchronous primary tumors of GC and CRC. We found that cellular components of juxta-tumoral sites were quite similar, while tumoral cellular components were specific to the tumoral sites. In addition, the mutational landscape and microbiome contributed to the distinct TME cellular components. Overall, we found that different prognoses and drug responses of GC and CRC were mainly due to the distinct TME determined by mutational landscape and microbiome components.
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spelling pubmed-96762412022-11-22 Genetic mutation and tumor microbiota determine heterogenicity of tumor immune signature: Evidence from gastric and colorectal synchronous cancers Yang, Weili Zhao, Yaxing Ge, Qiongxiang Wang, Xiaoli Jing, Yang Zhao, Jingwen Liu, Gang Huang, He Cheng, Fei Wang, Xiaoxi Ye, Yulin Song, Wenjing Liu, Xinjuan Du, Juan Sheng, Jianpeng Cao, Xiaocang Front Immunol Immunology Both colorectal and gastric cancer are lethal solid-tumor malignancies, leading to the majority of cancer-associated deaths worldwide. Although colorectal cancer (CRC) and gastric cancer (GC) share many similarities, the prognosis and drug response of CRC and GC are different. However, determinants for such differences have not been elucidated. To avoid genetic background variance, we performed multi-omics analysis, including single-cell RNA sequencing, whole-exome sequencing, and microbiome sequencing, to dissect the tumor immune signature of synchronous primary tumors of GC and CRC. We found that cellular components of juxta-tumoral sites were quite similar, while tumoral cellular components were specific to the tumoral sites. In addition, the mutational landscape and microbiome contributed to the distinct TME cellular components. Overall, we found that different prognoses and drug responses of GC and CRC were mainly due to the distinct TME determined by mutational landscape and microbiome components. Frontiers Media S.A. 2022-11-07 /pmc/articles/PMC9676241/ /pubmed/36420271 http://dx.doi.org/10.3389/fimmu.2022.947080 Text en Copyright © 2022 Yang, Zhao, Ge, Wang, Jing, Zhao, Liu, Huang, Cheng, Wang, Ye, Song, Liu, Du, Sheng and Cao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Yang, Weili
Zhao, Yaxing
Ge, Qiongxiang
Wang, Xiaoli
Jing, Yang
Zhao, Jingwen
Liu, Gang
Huang, He
Cheng, Fei
Wang, Xiaoxi
Ye, Yulin
Song, Wenjing
Liu, Xinjuan
Du, Juan
Sheng, Jianpeng
Cao, Xiaocang
Genetic mutation and tumor microbiota determine heterogenicity of tumor immune signature: Evidence from gastric and colorectal synchronous cancers
title Genetic mutation and tumor microbiota determine heterogenicity of tumor immune signature: Evidence from gastric and colorectal synchronous cancers
title_full Genetic mutation and tumor microbiota determine heterogenicity of tumor immune signature: Evidence from gastric and colorectal synchronous cancers
title_fullStr Genetic mutation and tumor microbiota determine heterogenicity of tumor immune signature: Evidence from gastric and colorectal synchronous cancers
title_full_unstemmed Genetic mutation and tumor microbiota determine heterogenicity of tumor immune signature: Evidence from gastric and colorectal synchronous cancers
title_short Genetic mutation and tumor microbiota determine heterogenicity of tumor immune signature: Evidence from gastric and colorectal synchronous cancers
title_sort genetic mutation and tumor microbiota determine heterogenicity of tumor immune signature: evidence from gastric and colorectal synchronous cancers
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676241/
https://www.ncbi.nlm.nih.gov/pubmed/36420271
http://dx.doi.org/10.3389/fimmu.2022.947080
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