Cargando…

Extracellular vesicle: A magic lamp to treat skin aging, refractory wound, and pigmented dermatosis?

Exposure of the skin to an external stimulus may lead to a series of irreversible dysfunctions, such as skin aging, refractory wounds, and pigmented dermatosis. Nowadays, many cutaneous treatments have failed to strike a balance between cosmetic needs and medical recovery. Extracellular vesicles (EV...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Haiyan, Zhang, Zhenchun, Zhang, Yuemeng, Zhao, Zhenlin, Zhu, Hongming, Yue, Changwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676268/
https://www.ncbi.nlm.nih.gov/pubmed/36420445
http://dx.doi.org/10.3389/fbioe.2022.1043320
_version_ 1784833555588710400
author Wu, Haiyan
Zhang, Zhenchun
Zhang, Yuemeng
Zhao, Zhenlin
Zhu, Hongming
Yue, Changwu
author_facet Wu, Haiyan
Zhang, Zhenchun
Zhang, Yuemeng
Zhao, Zhenlin
Zhu, Hongming
Yue, Changwu
author_sort Wu, Haiyan
collection PubMed
description Exposure of the skin to an external stimulus may lead to a series of irreversible dysfunctions, such as skin aging, refractory wounds, and pigmented dermatosis. Nowadays, many cutaneous treatments have failed to strike a balance between cosmetic needs and medical recovery. Extracellular vesicles (EVs) are one of the most promising therapeutic tools. EVs are cell-derived nanoparticles that can carry a variety of cargoes, such as nucleic acids, lipids, and proteins. They also have the ability to communicate with neighboring or distant cells. A growing body of evidence suggests that EVs play a significant role in skin repair. We summarize the current findings of EV therapy in skin aging, refractory wound, and pigmented dermatosis and also describe the novel engineering strategies for optimizing EV function and therapeutic outcomes.
format Online
Article
Text
id pubmed-9676268
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-96762682022-11-22 Extracellular vesicle: A magic lamp to treat skin aging, refractory wound, and pigmented dermatosis? Wu, Haiyan Zhang, Zhenchun Zhang, Yuemeng Zhao, Zhenlin Zhu, Hongming Yue, Changwu Front Bioeng Biotechnol Bioengineering and Biotechnology Exposure of the skin to an external stimulus may lead to a series of irreversible dysfunctions, such as skin aging, refractory wounds, and pigmented dermatosis. Nowadays, many cutaneous treatments have failed to strike a balance between cosmetic needs and medical recovery. Extracellular vesicles (EVs) are one of the most promising therapeutic tools. EVs are cell-derived nanoparticles that can carry a variety of cargoes, such as nucleic acids, lipids, and proteins. They also have the ability to communicate with neighboring or distant cells. A growing body of evidence suggests that EVs play a significant role in skin repair. We summarize the current findings of EV therapy in skin aging, refractory wound, and pigmented dermatosis and also describe the novel engineering strategies for optimizing EV function and therapeutic outcomes. Frontiers Media S.A. 2022-11-07 /pmc/articles/PMC9676268/ /pubmed/36420445 http://dx.doi.org/10.3389/fbioe.2022.1043320 Text en Copyright © 2022 Wu, Zhang, Zhang, Zhao, Zhu and Yue. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Wu, Haiyan
Zhang, Zhenchun
Zhang, Yuemeng
Zhao, Zhenlin
Zhu, Hongming
Yue, Changwu
Extracellular vesicle: A magic lamp to treat skin aging, refractory wound, and pigmented dermatosis?
title Extracellular vesicle: A magic lamp to treat skin aging, refractory wound, and pigmented dermatosis?
title_full Extracellular vesicle: A magic lamp to treat skin aging, refractory wound, and pigmented dermatosis?
title_fullStr Extracellular vesicle: A magic lamp to treat skin aging, refractory wound, and pigmented dermatosis?
title_full_unstemmed Extracellular vesicle: A magic lamp to treat skin aging, refractory wound, and pigmented dermatosis?
title_short Extracellular vesicle: A magic lamp to treat skin aging, refractory wound, and pigmented dermatosis?
title_sort extracellular vesicle: a magic lamp to treat skin aging, refractory wound, and pigmented dermatosis?
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676268/
https://www.ncbi.nlm.nih.gov/pubmed/36420445
http://dx.doi.org/10.3389/fbioe.2022.1043320
work_keys_str_mv AT wuhaiyan extracellularvesicleamagiclamptotreatskinagingrefractorywoundandpigmenteddermatosis
AT zhangzhenchun extracellularvesicleamagiclamptotreatskinagingrefractorywoundandpigmenteddermatosis
AT zhangyuemeng extracellularvesicleamagiclamptotreatskinagingrefractorywoundandpigmenteddermatosis
AT zhaozhenlin extracellularvesicleamagiclamptotreatskinagingrefractorywoundandpigmenteddermatosis
AT zhuhongming extracellularvesicleamagiclamptotreatskinagingrefractorywoundandpigmenteddermatosis
AT yuechangwu extracellularvesicleamagiclamptotreatskinagingrefractorywoundandpigmenteddermatosis