NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition

OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) ranges from steatosis to nonalcoholic steatohepatitis (NASH), which often progresses to hepatocellular carcinoma (HCC) through a largely undefined mechanism. NASH and HCC depend on inflammatory signaling, whose master regulator is the NFκB transcri...

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Detalles Bibliográficos
Autores principales: Vesting, Anna Juliane, Jais, Alexander, Klemm, Paul, Steuernagel, Lukas, Wienand, Peter, Fog-Tonnesen, Morten, Hvid, Henning, Schumacher, Anna–Lena, Kukat, Christian, Nolte, Hendrik, Georgomanolis, Theodoros, Altmüller, Janine, Pasparakis, Manolis, Schmidt, Andreas, Krüger, Marcus, Supprian, Marc Schmidt, Waisman, Ari, Straub, Beate Katharina, Raschzok, Nathanael, Bernier, Michel, Birkenfeld, Andreas L., Hövelmeyer, Nadine, Brüning, Jens C., Wunderlich, F. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676392/
https://www.ncbi.nlm.nih.gov/pubmed/36356831
http://dx.doi.org/10.1016/j.molmet.2022.101626

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