A novel site on dual-specificity phosphatase MKP7/DUSP16 is required for catalysis and MAPK binding

The dual-specificity phosphatases responsible for the inactivation of the mitogen-activated protein kinases (MAPKs) are designated as the MAPK phosphatases (MKPs). We demonstrated previously that MKP5 is regulated through a novel allosteric site suggesting additional regulatory mechanisms of catalys...

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Detalles Bibliográficos
Autores principales: Shillingford, Shanelle, Zhang, Lei, Surovtseva, Yulia, Dorry, Sam, Lolis, Elias, Bennett, Anton M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676401/
https://www.ncbi.nlm.nih.gov/pubmed/36272649
http://dx.doi.org/10.1016/j.jbc.2022.102617

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