Cargando…

Impact of WTAP in small HCC and paired adjacent non-neoplastic liver tissue on recurrence: A cohort study with external extension analysis

Background: To evaluate prognostic value of WTAP levels in tumor and paired adjacent non-neoplastic liver tissues (PANLT) for cases of hepatitis B virus (HBV)-positive Asian small hepatocellular carcinoma (sHCC) patients who received curative partial hepatectomy. Method: The investigation with two e...

Descripción completa

Detalles Bibliográficos
Autores principales: Duan, Jin-Ling, Deng, Min-Hua, Xiang, Zhi-Cheng, Hu, Jin-Long, Qu, Chun-Hua, Zhu, Tian-Chen, Xu, Ming-Xing, Chen, Jie-Wei, Xie, Juan-Juan, Xie, Dan, Cai, Mu-Yan, Li, Mei, Liang, Hu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676468/
https://www.ncbi.nlm.nih.gov/pubmed/36420139
http://dx.doi.org/10.3389/fcell.2022.973548
_version_ 1784833602389803008
author Duan, Jin-Ling
Deng, Min-Hua
Xiang, Zhi-Cheng
Hu, Jin-Long
Qu, Chun-Hua
Zhu, Tian-Chen
Xu, Ming-Xing
Chen, Jie-Wei
Xie, Juan-Juan
Xie, Dan
Cai, Mu-Yan
Li, Mei
Liang, Hu
author_facet Duan, Jin-Ling
Deng, Min-Hua
Xiang, Zhi-Cheng
Hu, Jin-Long
Qu, Chun-Hua
Zhu, Tian-Chen
Xu, Ming-Xing
Chen, Jie-Wei
Xie, Juan-Juan
Xie, Dan
Cai, Mu-Yan
Li, Mei
Liang, Hu
author_sort Duan, Jin-Ling
collection PubMed
description Background: To evaluate prognostic value of WTAP levels in tumor and paired adjacent non-neoplastic liver tissues (PANLT) for cases of hepatitis B virus (HBV)-positive Asian small hepatocellular carcinoma (sHCC) patients who received curative partial hepatectomy. Method: The investigation with two external cohorts were included. Associations between hazard risk of recurrence and continuous WTAP levels were investigated with restricted cubic spline models. Cox and inverse probability weighting models were established for survival analysis. Based on interaction effects, further stratification analysis was performed. Landmark analysis was employed to analyze cases of late recurrence. Finally, sensitivity analysis was performed to assess unmeasured confounders. Findings: In an investigation cohort of 307 patients, restricted cubic spline models indicated that hazard risk of recurrence increases with elevated WTAP levels for sHCC and PANLT. However, using Cox and inverse probability weighting models, no significant differences were observed in recurrence-free survival (RFS) between groups with different WTAP levels in sHCC. Multivariate analysis showed that patients with high PANLT WTAP levels had significantly worse RFS (HR 1.567, 95% CI 1.065–2.307; p = 0.023). Based on the significant interaction effect between WTAP levels in sHCC and PANLT, stratification analysis revealed that recurrence risk is more pronounced in patients with high WTAP levels in both PANLT and sHCC. Landmark analysis showed that late recurrence was more likely to occur in patients with high PANLT WTAP levels (HR 2.058, 95% CI 1.113–3.805; p = 0.021). Moreover, the detrimental effects of elevated PANLT WTAP levels on RFS were validated with two external cohorts. Sensitivity analysis confirmed the robustness of results. Conclusion: Increased PANLT WTAP expression levels independently predict high recurrence risk in HBV-positive Asian sHCC patients. Both tumor tissues and PANLT need to be considered together in future clinical practice to obtain a more comprehensive and accurate evaluation for recurrence risk.
format Online
Article
Text
id pubmed-9676468
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-96764682022-11-22 Impact of WTAP in small HCC and paired adjacent non-neoplastic liver tissue on recurrence: A cohort study with external extension analysis Duan, Jin-Ling Deng, Min-Hua Xiang, Zhi-Cheng Hu, Jin-Long Qu, Chun-Hua Zhu, Tian-Chen Xu, Ming-Xing Chen, Jie-Wei Xie, Juan-Juan Xie, Dan Cai, Mu-Yan Li, Mei Liang, Hu Front Cell Dev Biol Cell and Developmental Biology Background: To evaluate prognostic value of WTAP levels in tumor and paired adjacent non-neoplastic liver tissues (PANLT) for cases of hepatitis B virus (HBV)-positive Asian small hepatocellular carcinoma (sHCC) patients who received curative partial hepatectomy. Method: The investigation with two external cohorts were included. Associations between hazard risk of recurrence and continuous WTAP levels were investigated with restricted cubic spline models. Cox and inverse probability weighting models were established for survival analysis. Based on interaction effects, further stratification analysis was performed. Landmark analysis was employed to analyze cases of late recurrence. Finally, sensitivity analysis was performed to assess unmeasured confounders. Findings: In an investigation cohort of 307 patients, restricted cubic spline models indicated that hazard risk of recurrence increases with elevated WTAP levels for sHCC and PANLT. However, using Cox and inverse probability weighting models, no significant differences were observed in recurrence-free survival (RFS) between groups with different WTAP levels in sHCC. Multivariate analysis showed that patients with high PANLT WTAP levels had significantly worse RFS (HR 1.567, 95% CI 1.065–2.307; p = 0.023). Based on the significant interaction effect between WTAP levels in sHCC and PANLT, stratification analysis revealed that recurrence risk is more pronounced in patients with high WTAP levels in both PANLT and sHCC. Landmark analysis showed that late recurrence was more likely to occur in patients with high PANLT WTAP levels (HR 2.058, 95% CI 1.113–3.805; p = 0.021). Moreover, the detrimental effects of elevated PANLT WTAP levels on RFS were validated with two external cohorts. Sensitivity analysis confirmed the robustness of results. Conclusion: Increased PANLT WTAP expression levels independently predict high recurrence risk in HBV-positive Asian sHCC patients. Both tumor tissues and PANLT need to be considered together in future clinical practice to obtain a more comprehensive and accurate evaluation for recurrence risk. Frontiers Media S.A. 2022-11-07 /pmc/articles/PMC9676468/ /pubmed/36420139 http://dx.doi.org/10.3389/fcell.2022.973548 Text en Copyright © 2022 Duan, Deng, Xiang, Hu, Qu, Zhu, Xu, Chen, Xie, Xie, Cai, Li and Liang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Duan, Jin-Ling
Deng, Min-Hua
Xiang, Zhi-Cheng
Hu, Jin-Long
Qu, Chun-Hua
Zhu, Tian-Chen
Xu, Ming-Xing
Chen, Jie-Wei
Xie, Juan-Juan
Xie, Dan
Cai, Mu-Yan
Li, Mei
Liang, Hu
Impact of WTAP in small HCC and paired adjacent non-neoplastic liver tissue on recurrence: A cohort study with external extension analysis
title Impact of WTAP in small HCC and paired adjacent non-neoplastic liver tissue on recurrence: A cohort study with external extension analysis
title_full Impact of WTAP in small HCC and paired adjacent non-neoplastic liver tissue on recurrence: A cohort study with external extension analysis
title_fullStr Impact of WTAP in small HCC and paired adjacent non-neoplastic liver tissue on recurrence: A cohort study with external extension analysis
title_full_unstemmed Impact of WTAP in small HCC and paired adjacent non-neoplastic liver tissue on recurrence: A cohort study with external extension analysis
title_short Impact of WTAP in small HCC and paired adjacent non-neoplastic liver tissue on recurrence: A cohort study with external extension analysis
title_sort impact of wtap in small hcc and paired adjacent non-neoplastic liver tissue on recurrence: a cohort study with external extension analysis
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676468/
https://www.ncbi.nlm.nih.gov/pubmed/36420139
http://dx.doi.org/10.3389/fcell.2022.973548
work_keys_str_mv AT duanjinling impactofwtapinsmallhccandpairedadjacentnonneoplasticlivertissueonrecurrenceacohortstudywithexternalextensionanalysis
AT dengminhua impactofwtapinsmallhccandpairedadjacentnonneoplasticlivertissueonrecurrenceacohortstudywithexternalextensionanalysis
AT xiangzhicheng impactofwtapinsmallhccandpairedadjacentnonneoplasticlivertissueonrecurrenceacohortstudywithexternalextensionanalysis
AT hujinlong impactofwtapinsmallhccandpairedadjacentnonneoplasticlivertissueonrecurrenceacohortstudywithexternalextensionanalysis
AT quchunhua impactofwtapinsmallhccandpairedadjacentnonneoplasticlivertissueonrecurrenceacohortstudywithexternalextensionanalysis
AT zhutianchen impactofwtapinsmallhccandpairedadjacentnonneoplasticlivertissueonrecurrenceacohortstudywithexternalextensionanalysis
AT xumingxing impactofwtapinsmallhccandpairedadjacentnonneoplasticlivertissueonrecurrenceacohortstudywithexternalextensionanalysis
AT chenjiewei impactofwtapinsmallhccandpairedadjacentnonneoplasticlivertissueonrecurrenceacohortstudywithexternalextensionanalysis
AT xiejuanjuan impactofwtapinsmallhccandpairedadjacentnonneoplasticlivertissueonrecurrenceacohortstudywithexternalextensionanalysis
AT xiedan impactofwtapinsmallhccandpairedadjacentnonneoplasticlivertissueonrecurrenceacohortstudywithexternalextensionanalysis
AT caimuyan impactofwtapinsmallhccandpairedadjacentnonneoplasticlivertissueonrecurrenceacohortstudywithexternalextensionanalysis
AT limei impactofwtapinsmallhccandpairedadjacentnonneoplasticlivertissueonrecurrenceacohortstudywithexternalextensionanalysis
AT lianghu impactofwtapinsmallhccandpairedadjacentnonneoplasticlivertissueonrecurrenceacohortstudywithexternalextensionanalysis