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High-level of intratumoral GITR+ CD4 T cells associate with poor prognosis in gastric cancer

Immunotherapy targeting glucocorticoid-induced TNFR-related protein (GITR) exhibited strong anti-tumor capacity in mouse model but poor efficacy in clinical trials. This may be attributed to the different GITR expression mode between human and mouse. In this study, we analyzed single-cell RNA sequen...

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Detalles Bibliográficos
Autores principales:	Ke, Shouyu, Xie, Feng, Guo, Yixian, Chen, Jieqiong, Wang, Zeyu, Yu, Yimeng, Geng, Haigang, Xu, Danhua, Liu, Xu, Xia, Xiang, Yu, Fengrong, Zhu, Chunchao, Zhang, Zizhen, Zhao, Gang, Li, Bin, Zhao, Wenyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676631/ https://www.ncbi.nlm.nih.gov/pubmed/36419848 http://dx.doi.org/10.1016/j.isci.2022.105529

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