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Association between prenatal exposure to ambient ozone, birth weight, and macrosomia in healthy women

Studies have shown that prenatal ozone exposure is associated with an increased risk of adverse pregnancy outcomes, among which abnormal birth weight is a detrimental factor for diseases in adulthood, but the association between birth weight and ozone is inconclusive. Herein, we conducted this study...

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Autores principales: Zheng, Chengyi, Tian, Jiaqi, Ma, Lan, Ding, Chunjie, Zhang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676959/
https://www.ncbi.nlm.nih.gov/pubmed/36419998
http://dx.doi.org/10.3389/fpubh.2022.1000269
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author Zheng, Chengyi
Tian, Jiaqi
Ma, Lan
Ding, Chunjie
Zhang, Lin
author_facet Zheng, Chengyi
Tian, Jiaqi
Ma, Lan
Ding, Chunjie
Zhang, Lin
author_sort Zheng, Chengyi
collection PubMed
description Studies have shown that prenatal ozone exposure is associated with an increased risk of adverse pregnancy outcomes, among which abnormal birth weight is a detrimental factor for diseases in adulthood, but the association between birth weight and ozone is inconclusive. Herein, we conducted this study by enrolling 407 couples of pregnant women and collected their demographical materials, their exposure to ambient ozone was assessed according to the place of their residence. The hourly monitored ozone was first averaged to the daily level, then monthly and whole-gestationally levels. After adjusting confounders, we processed a multivariate generalized addictive analysis to predict the association between prenatal ozone exposure and birth weight. We also divided the cohort into two categories according to whether the infant met the standard of macrosomia, and the occurrence of macrosomia was studied via univariate and multivariate logistic regression analyses as extreme conditions of the effects of ozone exposure on birth weight. We found that the ground-level ozone in Jinan changed with temperature periodically, higher in summer and lower in winter. Over the past 8 years from 2014, the ambient ozone increased by 1.74 μg/m(3) per year. Of the 407 singleton-pregnant women, 21 infants were diagnosed with macrosomia. After adjusting confounders, we found that each unit increase in prenatal ozone exposure caused 8.80% [OR(ozone)90%CI: 0.912 (0.850, 0.978)] decreased risk of macrosomia, but the splined ambient ozone exposure data was not statistically associated with birth weight, which is probably due to the limited sample size. In conclusion, prenatal ozone exposure is associated with decreased risk of macrosomia but is weakly linked to birth weight.
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spelling pubmed-96769592022-11-22 Association between prenatal exposure to ambient ozone, birth weight, and macrosomia in healthy women Zheng, Chengyi Tian, Jiaqi Ma, Lan Ding, Chunjie Zhang, Lin Front Public Health Public Health Studies have shown that prenatal ozone exposure is associated with an increased risk of adverse pregnancy outcomes, among which abnormal birth weight is a detrimental factor for diseases in adulthood, but the association between birth weight and ozone is inconclusive. Herein, we conducted this study by enrolling 407 couples of pregnant women and collected their demographical materials, their exposure to ambient ozone was assessed according to the place of their residence. The hourly monitored ozone was first averaged to the daily level, then monthly and whole-gestationally levels. After adjusting confounders, we processed a multivariate generalized addictive analysis to predict the association between prenatal ozone exposure and birth weight. We also divided the cohort into two categories according to whether the infant met the standard of macrosomia, and the occurrence of macrosomia was studied via univariate and multivariate logistic regression analyses as extreme conditions of the effects of ozone exposure on birth weight. We found that the ground-level ozone in Jinan changed with temperature periodically, higher in summer and lower in winter. Over the past 8 years from 2014, the ambient ozone increased by 1.74 μg/m(3) per year. Of the 407 singleton-pregnant women, 21 infants were diagnosed with macrosomia. After adjusting confounders, we found that each unit increase in prenatal ozone exposure caused 8.80% [OR(ozone)90%CI: 0.912 (0.850, 0.978)] decreased risk of macrosomia, but the splined ambient ozone exposure data was not statistically associated with birth weight, which is probably due to the limited sample size. In conclusion, prenatal ozone exposure is associated with decreased risk of macrosomia but is weakly linked to birth weight. Frontiers Media S.A. 2022-11-07 /pmc/articles/PMC9676959/ /pubmed/36419998 http://dx.doi.org/10.3389/fpubh.2022.1000269 Text en Copyright © 2022 Zheng, Tian, Ma, Ding and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Zheng, Chengyi
Tian, Jiaqi
Ma, Lan
Ding, Chunjie
Zhang, Lin
Association between prenatal exposure to ambient ozone, birth weight, and macrosomia in healthy women
title Association between prenatal exposure to ambient ozone, birth weight, and macrosomia in healthy women
title_full Association between prenatal exposure to ambient ozone, birth weight, and macrosomia in healthy women
title_fullStr Association between prenatal exposure to ambient ozone, birth weight, and macrosomia in healthy women
title_full_unstemmed Association between prenatal exposure to ambient ozone, birth weight, and macrosomia in healthy women
title_short Association between prenatal exposure to ambient ozone, birth weight, and macrosomia in healthy women
title_sort association between prenatal exposure to ambient ozone, birth weight, and macrosomia in healthy women
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676959/
https://www.ncbi.nlm.nih.gov/pubmed/36419998
http://dx.doi.org/10.3389/fpubh.2022.1000269
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