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Selective observation of semi-rigid non-core residues in dynamically complex mutant huntingtin protein fibrils
Many amyloid-forming proteins, which are normally intrinsically disordered, undergo a disorder-to-order transition to form fibrils with a rigid β-sheet core flanked by disordered domains. Solid-state NMR (ssNMR) and cryogenic electron microscopy (cryoEM) excel at resolving the rigid structures withi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9677204/ https://www.ncbi.nlm.nih.gov/pubmed/36419510 http://dx.doi.org/10.1016/j.yjsbx.2022.100077 |