Evolutionary Action Score of TP53 Analysis in Pathologically High-Risk Human Papillomavirus-Negative Head and Neck Cancer From a Phase 2 Clinical Trial: NRG Oncology Radiation Therapy Oncology Group 0234

PURPOSE: An evolutionary action scoring algorithm (EAp53) based on phylogenetic sequence variations stratifies patients with head and neck squamous cell carcinoma (HNSCC) bearing TP53 missense mutations as high-risk, associated with poor outcomes, or low-risk, with similar outcomes as TP53 wild-type...

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Detalles Bibliográficos
Autores principales: Michikawa, Chieko, Torres-Saavedra, Pedro A., Silver, Natalie L., Harari, Paul M., Kies, Merrill S., Rosenthal, David I., Le, Quynh-Thu, Jordan, Richard C., Duose, Dzifa Y., Mallampati, Saradhi, Trivedi, Sanchit, Luthra, Rajyalakshmi, Wistuba, Ignacio I., Osman, Abdullah A., Lichtarge, Olivier, Foote, Robert L., Parvathaneni, Upendra, Hayes, D. Neil, Pickering, Curtis R., Myers, Jeffrey N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Scientific Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9677209/
https://www.ncbi.nlm.nih.gov/pubmed/36420184
http://dx.doi.org/10.1016/j.adro.2022.100989

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