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Ribosomal control in RNA virus-infected cells

Viruses are strictly intracellular parasites requiring host cellular functions to complete their reproduction cycle involving virus infection of host cell, viral genome replication, viral protein translation, and virion release. Ribosomes are protein synthesis factories in cells, and viruses need to...

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Detalles Bibliográficos
Autores principales: Wang, Xiao, Zhu, Jie, Zhang, Da, Liu, Guangqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9677555/
https://www.ncbi.nlm.nih.gov/pubmed/36419416
http://dx.doi.org/10.3389/fmicb.2022.1026887
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author Wang, Xiao
Zhu, Jie
Zhang, Da
Liu, Guangqing
author_facet Wang, Xiao
Zhu, Jie
Zhang, Da
Liu, Guangqing
author_sort Wang, Xiao
collection PubMed
description Viruses are strictly intracellular parasites requiring host cellular functions to complete their reproduction cycle involving virus infection of host cell, viral genome replication, viral protein translation, and virion release. Ribosomes are protein synthesis factories in cells, and viruses need to manipulate ribosomes to complete their protein synthesis. Viruses use translation initiation factors through their own RNA structures or cap structures, thereby inducing ribosomes to synthesize viral proteins. Viruses also affect ribosome production and the assembly of mature ribosomes, and regulate the recognition of mRNA by ribosomes, thereby promoting viral protein synthesis and inhibiting the synthesis of host antiviral immune proteins. Here, we review the remarkable mechanisms used by RNA viruses to regulate ribosomes, in particular, the mechanisms by which RNA viruses induce the formation of specific heterogeneous ribosomes required for viral protein translation. This review provides valuable insights into the control of viral infection and diseases from the perspective of viral protein synthesis.
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spelling pubmed-96775552022-11-22 Ribosomal control in RNA virus-infected cells Wang, Xiao Zhu, Jie Zhang, Da Liu, Guangqing Front Microbiol Microbiology Viruses are strictly intracellular parasites requiring host cellular functions to complete their reproduction cycle involving virus infection of host cell, viral genome replication, viral protein translation, and virion release. Ribosomes are protein synthesis factories in cells, and viruses need to manipulate ribosomes to complete their protein synthesis. Viruses use translation initiation factors through their own RNA structures or cap structures, thereby inducing ribosomes to synthesize viral proteins. Viruses also affect ribosome production and the assembly of mature ribosomes, and regulate the recognition of mRNA by ribosomes, thereby promoting viral protein synthesis and inhibiting the synthesis of host antiviral immune proteins. Here, we review the remarkable mechanisms used by RNA viruses to regulate ribosomes, in particular, the mechanisms by which RNA viruses induce the formation of specific heterogeneous ribosomes required for viral protein translation. This review provides valuable insights into the control of viral infection and diseases from the perspective of viral protein synthesis. Frontiers Media S.A. 2022-11-07 /pmc/articles/PMC9677555/ /pubmed/36419416 http://dx.doi.org/10.3389/fmicb.2022.1026887 Text en Copyright © 2022 Wang, Zhu, Zhang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Wang, Xiao
Zhu, Jie
Zhang, Da
Liu, Guangqing
Ribosomal control in RNA virus-infected cells
title Ribosomal control in RNA virus-infected cells
title_full Ribosomal control in RNA virus-infected cells
title_fullStr Ribosomal control in RNA virus-infected cells
title_full_unstemmed Ribosomal control in RNA virus-infected cells
title_short Ribosomal control in RNA virus-infected cells
title_sort ribosomal control in rna virus-infected cells
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9677555/
https://www.ncbi.nlm.nih.gov/pubmed/36419416
http://dx.doi.org/10.3389/fmicb.2022.1026887
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