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Caries Progression after Haematopoietic Stem Cell Transplantation and the Role of Hyposalivation

Haematopoietic stem cell transplantation (HSCT) preceded by a conditioning regimen is an established treatment option for many haematological diseases. Decreased salivary flow rates after HSCT may increase caries risk. We aim to estimate the extent to which caries lesions develop or progress in adul...

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Autores principales: Bulthuis, Marjolein S., van Gennip, Lucky L.A., Thomas, Renske Z., Bronkhorst, Ewald M., Laheij, Alexa M.G.A., Raber-Durlacher, Judith E., Rozema, Frederik R., Brennan, Michael T., von Bültzingslöwen, Inger, Blijlevens, Nicole M.A., van Leeuwen, Stephanie J.M., Huysmans, Marie-Charlotte D.N.J.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9677848/
https://www.ncbi.nlm.nih.gov/pubmed/35724637
http://dx.doi.org/10.1159/000525599
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author Bulthuis, Marjolein S.
van Gennip, Lucky L.A.
Thomas, Renske Z.
Bronkhorst, Ewald M.
Laheij, Alexa M.G.A.
Raber-Durlacher, Judith E.
Rozema, Frederik R.
Brennan, Michael T.
von Bültzingslöwen, Inger
Blijlevens, Nicole M.A.
van Leeuwen, Stephanie J.M.
Huysmans, Marie-Charlotte D.N.J.M.
author_facet Bulthuis, Marjolein S.
van Gennip, Lucky L.A.
Thomas, Renske Z.
Bronkhorst, Ewald M.
Laheij, Alexa M.G.A.
Raber-Durlacher, Judith E.
Rozema, Frederik R.
Brennan, Michael T.
von Bültzingslöwen, Inger
Blijlevens, Nicole M.A.
van Leeuwen, Stephanie J.M.
Huysmans, Marie-Charlotte D.N.J.M.
author_sort Bulthuis, Marjolein S.
collection PubMed
description Haematopoietic stem cell transplantation (HSCT) preceded by a conditioning regimen is an established treatment option for many haematological diseases. Decreased salivary flow rates after HSCT may increase caries risk. We aim to estimate the extent to which caries lesions develop or progress in adult HSCT recipients and assess its association with salivary flow rates. A multi-centre prospective observational study was conducted in which patients receiving HSCT were followed up for 18 months. We included 116 patients (median age 56 years, 43% female) from two medical centres in the Netherlands. Unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) were collected, and full caries charts were made before HSCT and 3, 6, 12, and 18 months post-HSCT. Caries was scored according to the ICDAS criteria by trained dentist-examiners. New dentine lesions or lesion progression into dentine (ICDAS ≥4 or cavitated root lesions) occurred in 32% of patients over 18 months. The median number of affected surfaces was 2 (range: 1–12) per patient with caries progression. The influence of hyposalivation of unstimulated saliva (<0.2 mL/min) and stimulated saliva (<0.7 mL/min) at baseline and after 3 months on caries progression was determined with a negative binomial regression model. Hyposalivation of SWS 3 months after HSCT was a significant risk indicator for caries progression (incidence rate ratio: 5.30, 95% CI: 2.09–13.4, p < 0.001), while hyposalivation of SWS at baseline and hyposalivation of UWS were not. We conclude that caries progression is a common oral complication in patients after HSCT, and stimulated hyposalivation shortly after treatment is a significant risk indicator for caries progression.
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spelling pubmed-96778482022-11-22 Caries Progression after Haematopoietic Stem Cell Transplantation and the Role of Hyposalivation Bulthuis, Marjolein S. van Gennip, Lucky L.A. Thomas, Renske Z. Bronkhorst, Ewald M. Laheij, Alexa M.G.A. Raber-Durlacher, Judith E. Rozema, Frederik R. Brennan, Michael T. von Bültzingslöwen, Inger Blijlevens, Nicole M.A. van Leeuwen, Stephanie J.M. Huysmans, Marie-Charlotte D.N.J.M. Caries Res Research Article Haematopoietic stem cell transplantation (HSCT) preceded by a conditioning regimen is an established treatment option for many haematological diseases. Decreased salivary flow rates after HSCT may increase caries risk. We aim to estimate the extent to which caries lesions develop or progress in adult HSCT recipients and assess its association with salivary flow rates. A multi-centre prospective observational study was conducted in which patients receiving HSCT were followed up for 18 months. We included 116 patients (median age 56 years, 43% female) from two medical centres in the Netherlands. Unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) were collected, and full caries charts were made before HSCT and 3, 6, 12, and 18 months post-HSCT. Caries was scored according to the ICDAS criteria by trained dentist-examiners. New dentine lesions or lesion progression into dentine (ICDAS ≥4 or cavitated root lesions) occurred in 32% of patients over 18 months. The median number of affected surfaces was 2 (range: 1–12) per patient with caries progression. The influence of hyposalivation of unstimulated saliva (<0.2 mL/min) and stimulated saliva (<0.7 mL/min) at baseline and after 3 months on caries progression was determined with a negative binomial regression model. Hyposalivation of SWS 3 months after HSCT was a significant risk indicator for caries progression (incidence rate ratio: 5.30, 95% CI: 2.09–13.4, p < 0.001), while hyposalivation of SWS at baseline and hyposalivation of UWS were not. We conclude that caries progression is a common oral complication in patients after HSCT, and stimulated hyposalivation shortly after treatment is a significant risk indicator for caries progression. S. Karger AG 2022-06-20 /pmc/articles/PMC9677848/ /pubmed/35724637 http://dx.doi.org/10.1159/000525599 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission.
spellingShingle Research Article
Bulthuis, Marjolein S.
van Gennip, Lucky L.A.
Thomas, Renske Z.
Bronkhorst, Ewald M.
Laheij, Alexa M.G.A.
Raber-Durlacher, Judith E.
Rozema, Frederik R.
Brennan, Michael T.
von Bültzingslöwen, Inger
Blijlevens, Nicole M.A.
van Leeuwen, Stephanie J.M.
Huysmans, Marie-Charlotte D.N.J.M.
Caries Progression after Haematopoietic Stem Cell Transplantation and the Role of Hyposalivation
title Caries Progression after Haematopoietic Stem Cell Transplantation and the Role of Hyposalivation
title_full Caries Progression after Haematopoietic Stem Cell Transplantation and the Role of Hyposalivation
title_fullStr Caries Progression after Haematopoietic Stem Cell Transplantation and the Role of Hyposalivation
title_full_unstemmed Caries Progression after Haematopoietic Stem Cell Transplantation and the Role of Hyposalivation
title_short Caries Progression after Haematopoietic Stem Cell Transplantation and the Role of Hyposalivation
title_sort caries progression after haematopoietic stem cell transplantation and the role of hyposalivation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9677848/
https://www.ncbi.nlm.nih.gov/pubmed/35724637
http://dx.doi.org/10.1159/000525599
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