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Growth Arrest-Specific 6 in Chromophobe Renal Cell Carcinoma
BACKGROUND: Overexpression of tumor-associated growth arrest-specific protein 6 (Gas6) is found in many tumor entities. The prognostic value of Gas6 in renal cell carcinoma (RCC), especially in non-clear cell RCC, is still unclear. AIM: The aim of the study was to evaluate the prognostic impact of G...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9677856/ https://www.ncbi.nlm.nih.gov/pubmed/35760058 http://dx.doi.org/10.1159/000525601 |
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author | Mikuteit, Marie Zschäbitz, Stefanie Erlmeier, Maximilian Autenrieth, Michael Weichert, Wilko Hartmann, Arndt Steffens, Sandra Erlmeier, Franziska |
author_facet | Mikuteit, Marie Zschäbitz, Stefanie Erlmeier, Maximilian Autenrieth, Michael Weichert, Wilko Hartmann, Arndt Steffens, Sandra Erlmeier, Franziska |
author_sort | Mikuteit, Marie |
collection | PubMed |
description | BACKGROUND: Overexpression of tumor-associated growth arrest-specific protein 6 (Gas6) is found in many tumor entities. The prognostic value of Gas6 in renal cell carcinoma (RCC), especially in non-clear cell RCC, is still unclear. AIM: The aim of the study was to evaluate the prognostic impact of Gas6 expression in a large cohort of patients with chromophobe RCC (chRCC). MATERIAL AND METHODS: Patients who underwent renal surgery due to chRCC were retrospectively evaluated. Tumor specimens were analyzed for Gas6 expression by immunohistochemistry. RESULTS: Eighty-one chRCC patients were eligible for analysis; of these, 24 (29.6%) patients were positive for Gas6. No significant associations were found for Gas6 expression and clinical attributes in patients with chRCC. The Kaplan-Meier analysis revealed no differences in 5-year overall survival for Gas6− compared to Gas6+ (89.6% vs. 100.0%; p = 0.288) tumors. CONCLUSION: In chRCC, Gas6 expression is not associated with survival and other parameters of aggressiveness. Due to the rare incidence of chRCC, further studies with larger cohorts are warranted. |
format | Online Article Text |
id | pubmed-9677856 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-96778562022-11-22 Growth Arrest-Specific 6 in Chromophobe Renal Cell Carcinoma Mikuteit, Marie Zschäbitz, Stefanie Erlmeier, Maximilian Autenrieth, Michael Weichert, Wilko Hartmann, Arndt Steffens, Sandra Erlmeier, Franziska Oncology Clinical Study BACKGROUND: Overexpression of tumor-associated growth arrest-specific protein 6 (Gas6) is found in many tumor entities. The prognostic value of Gas6 in renal cell carcinoma (RCC), especially in non-clear cell RCC, is still unclear. AIM: The aim of the study was to evaluate the prognostic impact of Gas6 expression in a large cohort of patients with chromophobe RCC (chRCC). MATERIAL AND METHODS: Patients who underwent renal surgery due to chRCC were retrospectively evaluated. Tumor specimens were analyzed for Gas6 expression by immunohistochemistry. RESULTS: Eighty-one chRCC patients were eligible for analysis; of these, 24 (29.6%) patients were positive for Gas6. No significant associations were found for Gas6 expression and clinical attributes in patients with chRCC. The Kaplan-Meier analysis revealed no differences in 5-year overall survival for Gas6− compared to Gas6+ (89.6% vs. 100.0%; p = 0.288) tumors. CONCLUSION: In chRCC, Gas6 expression is not associated with survival and other parameters of aggressiveness. Due to the rare incidence of chRCC, further studies with larger cohorts are warranted. S. Karger AG 2022-10 2022-06-27 /pmc/articles/PMC9677856/ /pubmed/35760058 http://dx.doi.org/10.1159/000525601 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by/4.0/This article is licensed under the Creative Commons Attribution 4.0 International License (CC BY). Usage, derivative works and distribution are permitted provided that proper credit is given to the author and the original publisher. |
spellingShingle | Clinical Study Mikuteit, Marie Zschäbitz, Stefanie Erlmeier, Maximilian Autenrieth, Michael Weichert, Wilko Hartmann, Arndt Steffens, Sandra Erlmeier, Franziska Growth Arrest-Specific 6 in Chromophobe Renal Cell Carcinoma |
title | Growth Arrest-Specific 6 in Chromophobe Renal Cell Carcinoma |
title_full | Growth Arrest-Specific 6 in Chromophobe Renal Cell Carcinoma |
title_fullStr | Growth Arrest-Specific 6 in Chromophobe Renal Cell Carcinoma |
title_full_unstemmed | Growth Arrest-Specific 6 in Chromophobe Renal Cell Carcinoma |
title_short | Growth Arrest-Specific 6 in Chromophobe Renal Cell Carcinoma |
title_sort | growth arrest-specific 6 in chromophobe renal cell carcinoma |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9677856/ https://www.ncbi.nlm.nih.gov/pubmed/35760058 http://dx.doi.org/10.1159/000525601 |
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