Cargando…
The global, regional, national burden of nasopharyngeal cancer and its attributable risk factors (1990–2019) and predictions to 2035
We aim to report the latest incidence, mortality, and disability‐adjusted life‐years (DALYs) between 1990 and 2019, by age, sex, sociodemographic index (SDI), and provide predictions to 2035. We use estimates from Global Burden of Disease, Injuries, and Risk Factors Study 2019 to analyze the inciden...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678109/ https://www.ncbi.nlm.nih.gov/pubmed/35475595 http://dx.doi.org/10.1002/cam4.4783 |
_version_ | 1784833923176464384 |
---|---|
author | Song, Yexun Cheng, Wenwei Li, Heqing Liu, Xiajing |
author_facet | Song, Yexun Cheng, Wenwei Li, Heqing Liu, Xiajing |
author_sort | Song, Yexun |
collection | PubMed |
description | We aim to report the latest incidence, mortality, and disability‐adjusted life‐years (DALYs) between 1990 and 2019, by age, sex, sociodemographic index (SDI), and provide predictions to 2035. We use estimates from Global Burden of Disease, Injuries, and Risk Factors Study 2019 to analyze the incidence, mortality, and DALYs. All the estimates were shown as counts and age‐standardized rates (ASR). In 2019, there were more than 176,501 (156,046 to 199,917) incidence cases, with ASRs of 2.1 (1.9 to 2.4). Nasopharyngeal cancer (NPC) accounted for 71,610 (65,442 to 77,625) deaths, with ASRs of 0.9 (0.8 to 0.9). NPC was also responsible for 2.34 million (2,139,753 to 2,536,657) DALYs, with ASRs of 28.0 (25.7 to 30.4). The count of all the new cases increased from 1990 to 2019. At the regional level, the highest age‐standardized incidence rates were found in East Asia, the highest age‐standardized death and DALY rates were shown in Southeast Asia. At the national level, the age‐standardized incidence rates were highest in Singapore, and the age‐standardized death and DALY rates were highest in Malaysia. The total numbers and rates of all the estimates were significantly higher among males than females across most of the age groups. The considerable burden of NPC was attributable to alcohol use, smoking, and occupational exposure to formaldehyde. A total of six GBD regions and 88 countries are projected to experience an increase in NPC ASRs between 2019 and 2035, respectively. Despite the current decline in age‐standardized mortality and DALY rates globally, the age‐standardized incidence rate has increased from 1990 to 2019, and continues to increase between 2020 and 2035, indicating that nasopharyngeal cancer remains a major health challenge worldwide. Prevention strategies should focus on modifiable risk factors, especially among males in East Asia. |
format | Online Article Text |
id | pubmed-9678109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96781092022-11-22 The global, regional, national burden of nasopharyngeal cancer and its attributable risk factors (1990–2019) and predictions to 2035 Song, Yexun Cheng, Wenwei Li, Heqing Liu, Xiajing Cancer Med RESEARCH ARTICLES We aim to report the latest incidence, mortality, and disability‐adjusted life‐years (DALYs) between 1990 and 2019, by age, sex, sociodemographic index (SDI), and provide predictions to 2035. We use estimates from Global Burden of Disease, Injuries, and Risk Factors Study 2019 to analyze the incidence, mortality, and DALYs. All the estimates were shown as counts and age‐standardized rates (ASR). In 2019, there were more than 176,501 (156,046 to 199,917) incidence cases, with ASRs of 2.1 (1.9 to 2.4). Nasopharyngeal cancer (NPC) accounted for 71,610 (65,442 to 77,625) deaths, with ASRs of 0.9 (0.8 to 0.9). NPC was also responsible for 2.34 million (2,139,753 to 2,536,657) DALYs, with ASRs of 28.0 (25.7 to 30.4). The count of all the new cases increased from 1990 to 2019. At the regional level, the highest age‐standardized incidence rates were found in East Asia, the highest age‐standardized death and DALY rates were shown in Southeast Asia. At the national level, the age‐standardized incidence rates were highest in Singapore, and the age‐standardized death and DALY rates were highest in Malaysia. The total numbers and rates of all the estimates were significantly higher among males than females across most of the age groups. The considerable burden of NPC was attributable to alcohol use, smoking, and occupational exposure to formaldehyde. A total of six GBD regions and 88 countries are projected to experience an increase in NPC ASRs between 2019 and 2035, respectively. Despite the current decline in age‐standardized mortality and DALY rates globally, the age‐standardized incidence rate has increased from 1990 to 2019, and continues to increase between 2020 and 2035, indicating that nasopharyngeal cancer remains a major health challenge worldwide. Prevention strategies should focus on modifiable risk factors, especially among males in East Asia. John Wiley and Sons Inc. 2022-04-27 /pmc/articles/PMC9678109/ /pubmed/35475595 http://dx.doi.org/10.1002/cam4.4783 Text en © 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | RESEARCH ARTICLES Song, Yexun Cheng, Wenwei Li, Heqing Liu, Xiajing The global, regional, national burden of nasopharyngeal cancer and its attributable risk factors (1990–2019) and predictions to 2035 |
title | The global, regional, national burden of nasopharyngeal cancer and its attributable risk factors (1990–2019) and predictions to 2035 |
title_full | The global, regional, national burden of nasopharyngeal cancer and its attributable risk factors (1990–2019) and predictions to 2035 |
title_fullStr | The global, regional, national burden of nasopharyngeal cancer and its attributable risk factors (1990–2019) and predictions to 2035 |
title_full_unstemmed | The global, regional, national burden of nasopharyngeal cancer and its attributable risk factors (1990–2019) and predictions to 2035 |
title_short | The global, regional, national burden of nasopharyngeal cancer and its attributable risk factors (1990–2019) and predictions to 2035 |
title_sort | global, regional, national burden of nasopharyngeal cancer and its attributable risk factors (1990–2019) and predictions to 2035 |
topic | RESEARCH ARTICLES |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678109/ https://www.ncbi.nlm.nih.gov/pubmed/35475595 http://dx.doi.org/10.1002/cam4.4783 |
work_keys_str_mv | AT songyexun theglobalregionalnationalburdenofnasopharyngealcanceranditsattributableriskfactors19902019andpredictionsto2035 AT chengwenwei theglobalregionalnationalburdenofnasopharyngealcanceranditsattributableriskfactors19902019andpredictionsto2035 AT liheqing theglobalregionalnationalburdenofnasopharyngealcanceranditsattributableriskfactors19902019andpredictionsto2035 AT liuxiajing theglobalregionalnationalburdenofnasopharyngealcanceranditsattributableriskfactors19902019andpredictionsto2035 AT songyexun globalregionalnationalburdenofnasopharyngealcanceranditsattributableriskfactors19902019andpredictionsto2035 AT chengwenwei globalregionalnationalburdenofnasopharyngealcanceranditsattributableriskfactors19902019andpredictionsto2035 AT liheqing globalregionalnationalburdenofnasopharyngealcanceranditsattributableriskfactors19902019andpredictionsto2035 AT liuxiajing globalregionalnationalburdenofnasopharyngealcanceranditsattributableriskfactors19902019andpredictionsto2035 |