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The Role of Diffusion-Weighted Magnetic Resonance Imaging in Differentiating Benign From Malignant Thyroid Nodules: A Descriptive Observational Study

Background Currently, no effective and reproducible imaging method can quantitatively differentiate between benign and malignant thyroid nodules. This study aimed to assess the role of diffusion-weighted imaging (DWI) in differentiating benign from malignant thyroid nodules. Methodology We conducted...

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Autores principales: Monisha, Vijaykumar, Rache Gowda, N, Anil Kumar, Sakalecha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678236/
https://www.ncbi.nlm.nih.gov/pubmed/36420224
http://dx.doi.org/10.7759/cureus.30493
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author Monisha, Vijaykumar
Rache Gowda, N
Anil Kumar, Sakalecha
author_facet Monisha, Vijaykumar
Rache Gowda, N
Anil Kumar, Sakalecha
author_sort Monisha, Vijaykumar
collection PubMed
description Background Currently, no effective and reproducible imaging method can quantitatively differentiate between benign and malignant thyroid nodules. This study aimed to assess the role of diffusion-weighted imaging (DWI) in differentiating benign from malignant thyroid nodules. Methodology We conducted an observational study in the Department of Radiodiagnosis at R. L. Jalappa Hospital and Research Center, Kolar, India. The study was conducted from January 2020 to June 2021, among 43 patients with thyroid swelling or nodules. We recorded patient baseline data, pertinent clinical history, and relevant laboratory investigations. Patients underwent diffusion-weighted MRI of the neck. We used receiver operator curve analysis to determine the utility of the apparent diffusion coefficient (ADC) of the thyroid nodule in predicting the histopathological diagnosis. Data were analyzed using coGuide (V1.0.3, BDSS Corp., India). Results A total of 43 patients were enrolled in the study (35 women, 81.4%; 8 men, 18.6%). The mean (SD) age was 49.8 (14.3) years. Nodular hyperplasia was the most common histopathologic diagnosis of the nodule (25.5%), followed by lymphocytic thyroiditis (16.2%). The MRI and histopathological findings matched: both found 35 (81.4%) nodules as benign and 8 (18.6%) as malignant. The ADC value of thyroid nodules had excellent predictive validity in predicting malignancy, as indicated by the area under the curve of 0.925 (95% confidence interval [CI] 0.804-1.000; p < 0.001). The sensitivity was 87.50% (95% CI 47.35%-99.68%), specificity was 94.29% (95% CI 80.84%-99.30%), and the total diagnostic accuracy obtained was 93.02% (95% CI 80.94%-98.54%). Conclusions DWI with ADC measurement has the potential to differentiate between benign and malignant thyroid nodules.
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spelling pubmed-96782362022-11-22 The Role of Diffusion-Weighted Magnetic Resonance Imaging in Differentiating Benign From Malignant Thyroid Nodules: A Descriptive Observational Study Monisha, Vijaykumar Rache Gowda, N Anil Kumar, Sakalecha Cureus Endocrinology/Diabetes/Metabolism Background Currently, no effective and reproducible imaging method can quantitatively differentiate between benign and malignant thyroid nodules. This study aimed to assess the role of diffusion-weighted imaging (DWI) in differentiating benign from malignant thyroid nodules. Methodology We conducted an observational study in the Department of Radiodiagnosis at R. L. Jalappa Hospital and Research Center, Kolar, India. The study was conducted from January 2020 to June 2021, among 43 patients with thyroid swelling or nodules. We recorded patient baseline data, pertinent clinical history, and relevant laboratory investigations. Patients underwent diffusion-weighted MRI of the neck. We used receiver operator curve analysis to determine the utility of the apparent diffusion coefficient (ADC) of the thyroid nodule in predicting the histopathological diagnosis. Data were analyzed using coGuide (V1.0.3, BDSS Corp., India). Results A total of 43 patients were enrolled in the study (35 women, 81.4%; 8 men, 18.6%). The mean (SD) age was 49.8 (14.3) years. Nodular hyperplasia was the most common histopathologic diagnosis of the nodule (25.5%), followed by lymphocytic thyroiditis (16.2%). The MRI and histopathological findings matched: both found 35 (81.4%) nodules as benign and 8 (18.6%) as malignant. The ADC value of thyroid nodules had excellent predictive validity in predicting malignancy, as indicated by the area under the curve of 0.925 (95% confidence interval [CI] 0.804-1.000; p < 0.001). The sensitivity was 87.50% (95% CI 47.35%-99.68%), specificity was 94.29% (95% CI 80.84%-99.30%), and the total diagnostic accuracy obtained was 93.02% (95% CI 80.94%-98.54%). Conclusions DWI with ADC measurement has the potential to differentiate between benign and malignant thyroid nodules. Cureus 2022-10-19 /pmc/articles/PMC9678236/ /pubmed/36420224 http://dx.doi.org/10.7759/cureus.30493 Text en Copyright © 2022, Monisha et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Monisha, Vijaykumar
Rache Gowda, N
Anil Kumar, Sakalecha
The Role of Diffusion-Weighted Magnetic Resonance Imaging in Differentiating Benign From Malignant Thyroid Nodules: A Descriptive Observational Study
title The Role of Diffusion-Weighted Magnetic Resonance Imaging in Differentiating Benign From Malignant Thyroid Nodules: A Descriptive Observational Study
title_full The Role of Diffusion-Weighted Magnetic Resonance Imaging in Differentiating Benign From Malignant Thyroid Nodules: A Descriptive Observational Study
title_fullStr The Role of Diffusion-Weighted Magnetic Resonance Imaging in Differentiating Benign From Malignant Thyroid Nodules: A Descriptive Observational Study
title_full_unstemmed The Role of Diffusion-Weighted Magnetic Resonance Imaging in Differentiating Benign From Malignant Thyroid Nodules: A Descriptive Observational Study
title_short The Role of Diffusion-Weighted Magnetic Resonance Imaging in Differentiating Benign From Malignant Thyroid Nodules: A Descriptive Observational Study
title_sort role of diffusion-weighted magnetic resonance imaging in differentiating benign from malignant thyroid nodules: a descriptive observational study
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678236/
https://www.ncbi.nlm.nih.gov/pubmed/36420224
http://dx.doi.org/10.7759/cureus.30493
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