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Relation Between Familial Mediterranean Fever and QT Markers (QTc, QTd, and QTcd): A Systematic Review and Meta-Analysis

The aim of this study is to perform a meta-analysis to evaluate the possible association betweenQT markers and familial Mediterranean fever (FMF). PUBMED, Web of Science, OVID, and SCOPUS databases were searched. Inclusion criteria were randomized control trials or observational studies that compare...

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Autores principales: Motawea, Karam R, El-Sakka, Amro A, Kandil, Omneya A, Ahmed, Nancy, Abdelnaem, Merna, Zaki, Bishoy, Elhalag, Rowan H, Varney, Joseph, Swed, Sarya, Nashwan, Abdulqadir J, Sawaf, Bisher, Seijari, Mohamed, Farwati, Amr, Battikh, Naim, Rakab, Amine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678238/
https://www.ncbi.nlm.nih.gov/pubmed/36420231
http://dx.doi.org/10.7759/cureus.30585
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author Motawea, Karam R
El-Sakka, Amro A
Kandil, Omneya A
Ahmed, Nancy
Abdelnaem, Merna
Zaki, Bishoy
Elhalag, Rowan H
Varney, Joseph
Swed, Sarya
Nashwan, Abdulqadir J
Sawaf, Bisher
Seijari, Mohamed
Farwati, Amr
Battikh, Naim
Rakab, Amine
author_facet Motawea, Karam R
El-Sakka, Amro A
Kandil, Omneya A
Ahmed, Nancy
Abdelnaem, Merna
Zaki, Bishoy
Elhalag, Rowan H
Varney, Joseph
Swed, Sarya
Nashwan, Abdulqadir J
Sawaf, Bisher
Seijari, Mohamed
Farwati, Amr
Battikh, Naim
Rakab, Amine
author_sort Motawea, Karam R
collection PubMed
description The aim of this study is to perform a meta-analysis to evaluate the possible association betweenQT markers and familial Mediterranean fever (FMF). PUBMED, Web of Science, OVID, and SCOPUS databases were searched. Inclusion criteria were randomized control trials or observational studies that compared measurement of the QT markers in FMF patients and healthy controls in both males and females without any age restriction or other comorbidities. RevMan software (5.4) was used to perform the analysis. A total of 14 studies with 1,154 individuals were included in the study. The pooled effect estimate showed a statistically significant association between FMF group and prolonged corrected QT (QTc) and QT dispersion (QTd) (MD= 7.06, 95% CI = 2.68 to 11.43, p-value = 0.002) and (MD= 6.08, 95% CI = 0.84 to 11.32, p-value= 0.02), respectively. No statistically significant difference between FMF group and QT interval and corrected QT dispersion (QTcd) (MD= 2.34, 95% CI = -1.21 to 5.89, p-value = 0.20) and (MD= 4.82, 95% CI = -0.57 to 10.20, p-value = 0.08), respectively. Our findings revealed a statistically significant relationship between FMF and extended QTc and QTd. More randomized multicenter trials are required to confirm our findings.
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spelling pubmed-96782382022-11-22 Relation Between Familial Mediterranean Fever and QT Markers (QTc, QTd, and QTcd): A Systematic Review and Meta-Analysis Motawea, Karam R El-Sakka, Amro A Kandil, Omneya A Ahmed, Nancy Abdelnaem, Merna Zaki, Bishoy Elhalag, Rowan H Varney, Joseph Swed, Sarya Nashwan, Abdulqadir J Sawaf, Bisher Seijari, Mohamed Farwati, Amr Battikh, Naim Rakab, Amine Cureus Cardiology The aim of this study is to perform a meta-analysis to evaluate the possible association betweenQT markers and familial Mediterranean fever (FMF). PUBMED, Web of Science, OVID, and SCOPUS databases were searched. Inclusion criteria were randomized control trials or observational studies that compared measurement of the QT markers in FMF patients and healthy controls in both males and females without any age restriction or other comorbidities. RevMan software (5.4) was used to perform the analysis. A total of 14 studies with 1,154 individuals were included in the study. The pooled effect estimate showed a statistically significant association between FMF group and prolonged corrected QT (QTc) and QT dispersion (QTd) (MD= 7.06, 95% CI = 2.68 to 11.43, p-value = 0.002) and (MD= 6.08, 95% CI = 0.84 to 11.32, p-value= 0.02), respectively. No statistically significant difference between FMF group and QT interval and corrected QT dispersion (QTcd) (MD= 2.34, 95% CI = -1.21 to 5.89, p-value = 0.20) and (MD= 4.82, 95% CI = -0.57 to 10.20, p-value = 0.08), respectively. Our findings revealed a statistically significant relationship between FMF and extended QTc and QTd. More randomized multicenter trials are required to confirm our findings. Cureus 2022-10-22 /pmc/articles/PMC9678238/ /pubmed/36420231 http://dx.doi.org/10.7759/cureus.30585 Text en Copyright © 2022, Motawea et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Motawea, Karam R
El-Sakka, Amro A
Kandil, Omneya A
Ahmed, Nancy
Abdelnaem, Merna
Zaki, Bishoy
Elhalag, Rowan H
Varney, Joseph
Swed, Sarya
Nashwan, Abdulqadir J
Sawaf, Bisher
Seijari, Mohamed
Farwati, Amr
Battikh, Naim
Rakab, Amine
Relation Between Familial Mediterranean Fever and QT Markers (QTc, QTd, and QTcd): A Systematic Review and Meta-Analysis
title Relation Between Familial Mediterranean Fever and QT Markers (QTc, QTd, and QTcd): A Systematic Review and Meta-Analysis
title_full Relation Between Familial Mediterranean Fever and QT Markers (QTc, QTd, and QTcd): A Systematic Review and Meta-Analysis
title_fullStr Relation Between Familial Mediterranean Fever and QT Markers (QTc, QTd, and QTcd): A Systematic Review and Meta-Analysis
title_full_unstemmed Relation Between Familial Mediterranean Fever and QT Markers (QTc, QTd, and QTcd): A Systematic Review and Meta-Analysis
title_short Relation Between Familial Mediterranean Fever and QT Markers (QTc, QTd, and QTcd): A Systematic Review and Meta-Analysis
title_sort relation between familial mediterranean fever and qt markers (qtc, qtd, and qtcd): a systematic review and meta-analysis
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678238/
https://www.ncbi.nlm.nih.gov/pubmed/36420231
http://dx.doi.org/10.7759/cureus.30585
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