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Biomarkers of sickle cell nephropathy in Senegal
Sickle cell anemia (SCA) is caused by a single point variation in the β-globin gene (HBB): c.20A> T (p.Glu7Val), in homozygous state. SCA is characterized by sickling of red blood cells in small blood vessels which leads to a range of multiorgan complications, including kidney dysfunction. This c...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678278/ https://www.ncbi.nlm.nih.gov/pubmed/36409722 http://dx.doi.org/10.1371/journal.pone.0273745 |
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author | Ndour, El Hadji Malick Mnika, Khuthala Tall, Fatou Guèye Seck, Moussa Ly, Indou Dème Nembaware, Victoria Mazandu, Gaston Kuzamunu Sagna Bassène, Hélène Ange Thérèse Dione, Rokhaya Ndongo, Aliou Abdoulaye Diop, Jean Pascal Demba Barry, Nènè Oumou Kesso Djité, Moustapha Ndiaye Diallo, Rokhaya Guèye, Papa Madièye Diop, Saliou Diagne, Ibrahima Cissé, Aynina Wonkam, Ambroise Lopez Sall, Philomène |
author_facet | Ndour, El Hadji Malick Mnika, Khuthala Tall, Fatou Guèye Seck, Moussa Ly, Indou Dème Nembaware, Victoria Mazandu, Gaston Kuzamunu Sagna Bassène, Hélène Ange Thérèse Dione, Rokhaya Ndongo, Aliou Abdoulaye Diop, Jean Pascal Demba Barry, Nènè Oumou Kesso Djité, Moustapha Ndiaye Diallo, Rokhaya Guèye, Papa Madièye Diop, Saliou Diagne, Ibrahima Cissé, Aynina Wonkam, Ambroise Lopez Sall, Philomène |
author_sort | Ndour, El Hadji Malick |
collection | PubMed |
description | Sickle cell anemia (SCA) is caused by a single point variation in the β-globin gene (HBB): c.20A> T (p.Glu7Val), in homozygous state. SCA is characterized by sickling of red blood cells in small blood vessels which leads to a range of multiorgan complications, including kidney dysfunction. This case-control study aims at identifying sickle cell nephropathy biomarkers in a group of patients living with SCA from Senegal. A total of 163 patients living with SCA and 177 ethnic matched controls were investigated. Biological phenotyping included evaluation of glycemia, glucosuria, albuminuria, proteinuria, tubular proteinuria, serum creatinine, urine creatinine, urine specific gravity and glomerular filtration rate. Descriptive statistics of biomarkers were performed using the χ2 –test, with the significance level set at p<0.05. Patients living with SCA had a median age of 20 years (range 4 to 57) with a female sex frequency of 53.21%. The median age of the control participants was 29 years (range: 4–77) with a female sex frequency of 66.09%. The following proportions of abnormal biological indices were observed in SCA patients versus (vs.) controls, as follows: hyposthenuria: 35.3%vs.5.2% (p<0.001); glomerular hyperfiltration: 47.66%vs.19.75% (p<0.001), renal insufficiency: 5.47%vs.3.82% (p = 0.182); microalbuminuria: 42.38%vs.5.78% (p<0.001); proteinuria: 39.33%vs.4.62% (p<0.001); tubular proteinuria: 40.97%vs.4.73% (p<0.001) and microglucosuria: 22.5%vs.5.1% (p<0.001). This study shows a relatively high proportion of SCA nephropathy among patients living with SCA in Senegal. Microglucosuria, proteinuria, tubular proteinuria, microalbuminuria, hyposthenuria and glomerular hyperfiltration are the most prevalent biomarkers of nephropathy in this group of Senegalese patients with SCA. |
format | Online Article Text |
id | pubmed-9678278 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-96782782022-11-22 Biomarkers of sickle cell nephropathy in Senegal Ndour, El Hadji Malick Mnika, Khuthala Tall, Fatou Guèye Seck, Moussa Ly, Indou Dème Nembaware, Victoria Mazandu, Gaston Kuzamunu Sagna Bassène, Hélène Ange Thérèse Dione, Rokhaya Ndongo, Aliou Abdoulaye Diop, Jean Pascal Demba Barry, Nènè Oumou Kesso Djité, Moustapha Ndiaye Diallo, Rokhaya Guèye, Papa Madièye Diop, Saliou Diagne, Ibrahima Cissé, Aynina Wonkam, Ambroise Lopez Sall, Philomène PLoS One Research Article Sickle cell anemia (SCA) is caused by a single point variation in the β-globin gene (HBB): c.20A> T (p.Glu7Val), in homozygous state. SCA is characterized by sickling of red blood cells in small blood vessels which leads to a range of multiorgan complications, including kidney dysfunction. This case-control study aims at identifying sickle cell nephropathy biomarkers in a group of patients living with SCA from Senegal. A total of 163 patients living with SCA and 177 ethnic matched controls were investigated. Biological phenotyping included evaluation of glycemia, glucosuria, albuminuria, proteinuria, tubular proteinuria, serum creatinine, urine creatinine, urine specific gravity and glomerular filtration rate. Descriptive statistics of biomarkers were performed using the χ2 –test, with the significance level set at p<0.05. Patients living with SCA had a median age of 20 years (range 4 to 57) with a female sex frequency of 53.21%. The median age of the control participants was 29 years (range: 4–77) with a female sex frequency of 66.09%. The following proportions of abnormal biological indices were observed in SCA patients versus (vs.) controls, as follows: hyposthenuria: 35.3%vs.5.2% (p<0.001); glomerular hyperfiltration: 47.66%vs.19.75% (p<0.001), renal insufficiency: 5.47%vs.3.82% (p = 0.182); microalbuminuria: 42.38%vs.5.78% (p<0.001); proteinuria: 39.33%vs.4.62% (p<0.001); tubular proteinuria: 40.97%vs.4.73% (p<0.001) and microglucosuria: 22.5%vs.5.1% (p<0.001). This study shows a relatively high proportion of SCA nephropathy among patients living with SCA in Senegal. Microglucosuria, proteinuria, tubular proteinuria, microalbuminuria, hyposthenuria and glomerular hyperfiltration are the most prevalent biomarkers of nephropathy in this group of Senegalese patients with SCA. Public Library of Science 2022-11-21 /pmc/articles/PMC9678278/ /pubmed/36409722 http://dx.doi.org/10.1371/journal.pone.0273745 Text en © 2022 Ndour et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Ndour, El Hadji Malick Mnika, Khuthala Tall, Fatou Guèye Seck, Moussa Ly, Indou Dème Nembaware, Victoria Mazandu, Gaston Kuzamunu Sagna Bassène, Hélène Ange Thérèse Dione, Rokhaya Ndongo, Aliou Abdoulaye Diop, Jean Pascal Demba Barry, Nènè Oumou Kesso Djité, Moustapha Ndiaye Diallo, Rokhaya Guèye, Papa Madièye Diop, Saliou Diagne, Ibrahima Cissé, Aynina Wonkam, Ambroise Lopez Sall, Philomène Biomarkers of sickle cell nephropathy in Senegal |
title | Biomarkers of sickle cell nephropathy in Senegal |
title_full | Biomarkers of sickle cell nephropathy in Senegal |
title_fullStr | Biomarkers of sickle cell nephropathy in Senegal |
title_full_unstemmed | Biomarkers of sickle cell nephropathy in Senegal |
title_short | Biomarkers of sickle cell nephropathy in Senegal |
title_sort | biomarkers of sickle cell nephropathy in senegal |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678278/ https://www.ncbi.nlm.nih.gov/pubmed/36409722 http://dx.doi.org/10.1371/journal.pone.0273745 |
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