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Biomarkers of sickle cell nephropathy in Senegal

Sickle cell anemia (SCA) is caused by a single point variation in the β-globin gene (HBB): c.20A> T (p.Glu7Val), in homozygous state. SCA is characterized by sickling of red blood cells in small blood vessels which leads to a range of multiorgan complications, including kidney dysfunction. This c...

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Autores principales: Ndour, El Hadji Malick, Mnika, Khuthala, Tall, Fatou Guèye, Seck, Moussa, Ly, Indou Dème, Nembaware, Victoria, Mazandu, Gaston Kuzamunu, Sagna Bassène, Hélène Ange Thérèse, Dione, Rokhaya, Ndongo, Aliou Abdoulaye, Diop, Jean Pascal Demba, Barry, Nènè Oumou Kesso, Djité, Moustapha, Ndiaye Diallo, Rokhaya, Guèye, Papa Madièye, Diop, Saliou, Diagne, Ibrahima, Cissé, Aynina, Wonkam, Ambroise, Lopez Sall, Philomène
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678278/
https://www.ncbi.nlm.nih.gov/pubmed/36409722
http://dx.doi.org/10.1371/journal.pone.0273745
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author Ndour, El Hadji Malick
Mnika, Khuthala
Tall, Fatou Guèye
Seck, Moussa
Ly, Indou Dème
Nembaware, Victoria
Mazandu, Gaston Kuzamunu
Sagna Bassène, Hélène Ange Thérèse
Dione, Rokhaya
Ndongo, Aliou Abdoulaye
Diop, Jean Pascal Demba
Barry, Nènè Oumou Kesso
Djité, Moustapha
Ndiaye Diallo, Rokhaya
Guèye, Papa Madièye
Diop, Saliou
Diagne, Ibrahima
Cissé, Aynina
Wonkam, Ambroise
Lopez Sall, Philomène
author_facet Ndour, El Hadji Malick
Mnika, Khuthala
Tall, Fatou Guèye
Seck, Moussa
Ly, Indou Dème
Nembaware, Victoria
Mazandu, Gaston Kuzamunu
Sagna Bassène, Hélène Ange Thérèse
Dione, Rokhaya
Ndongo, Aliou Abdoulaye
Diop, Jean Pascal Demba
Barry, Nènè Oumou Kesso
Djité, Moustapha
Ndiaye Diallo, Rokhaya
Guèye, Papa Madièye
Diop, Saliou
Diagne, Ibrahima
Cissé, Aynina
Wonkam, Ambroise
Lopez Sall, Philomène
author_sort Ndour, El Hadji Malick
collection PubMed
description Sickle cell anemia (SCA) is caused by a single point variation in the β-globin gene (HBB): c.20A> T (p.Glu7Val), in homozygous state. SCA is characterized by sickling of red blood cells in small blood vessels which leads to a range of multiorgan complications, including kidney dysfunction. This case-control study aims at identifying sickle cell nephropathy biomarkers in a group of patients living with SCA from Senegal. A total of 163 patients living with SCA and 177 ethnic matched controls were investigated. Biological phenotyping included evaluation of glycemia, glucosuria, albuminuria, proteinuria, tubular proteinuria, serum creatinine, urine creatinine, urine specific gravity and glomerular filtration rate. Descriptive statistics of biomarkers were performed using the χ2 –test, with the significance level set at p<0.05. Patients living with SCA had a median age of 20 years (range 4 to 57) with a female sex frequency of 53.21%. The median age of the control participants was 29 years (range: 4–77) with a female sex frequency of 66.09%. The following proportions of abnormal biological indices were observed in SCA patients versus (vs.) controls, as follows: hyposthenuria: 35.3%vs.5.2% (p<0.001); glomerular hyperfiltration: 47.66%vs.19.75% (p<0.001), renal insufficiency: 5.47%vs.3.82% (p = 0.182); microalbuminuria: 42.38%vs.5.78% (p<0.001); proteinuria: 39.33%vs.4.62% (p<0.001); tubular proteinuria: 40.97%vs.4.73% (p<0.001) and microglucosuria: 22.5%vs.5.1% (p<0.001). This study shows a relatively high proportion of SCA nephropathy among patients living with SCA in Senegal. Microglucosuria, proteinuria, tubular proteinuria, microalbuminuria, hyposthenuria and glomerular hyperfiltration are the most prevalent biomarkers of nephropathy in this group of Senegalese patients with SCA.
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spelling pubmed-96782782022-11-22 Biomarkers of sickle cell nephropathy in Senegal Ndour, El Hadji Malick Mnika, Khuthala Tall, Fatou Guèye Seck, Moussa Ly, Indou Dème Nembaware, Victoria Mazandu, Gaston Kuzamunu Sagna Bassène, Hélène Ange Thérèse Dione, Rokhaya Ndongo, Aliou Abdoulaye Diop, Jean Pascal Demba Barry, Nènè Oumou Kesso Djité, Moustapha Ndiaye Diallo, Rokhaya Guèye, Papa Madièye Diop, Saliou Diagne, Ibrahima Cissé, Aynina Wonkam, Ambroise Lopez Sall, Philomène PLoS One Research Article Sickle cell anemia (SCA) is caused by a single point variation in the β-globin gene (HBB): c.20A> T (p.Glu7Val), in homozygous state. SCA is characterized by sickling of red blood cells in small blood vessels which leads to a range of multiorgan complications, including kidney dysfunction. This case-control study aims at identifying sickle cell nephropathy biomarkers in a group of patients living with SCA from Senegal. A total of 163 patients living with SCA and 177 ethnic matched controls were investigated. Biological phenotyping included evaluation of glycemia, glucosuria, albuminuria, proteinuria, tubular proteinuria, serum creatinine, urine creatinine, urine specific gravity and glomerular filtration rate. Descriptive statistics of biomarkers were performed using the χ2 –test, with the significance level set at p<0.05. Patients living with SCA had a median age of 20 years (range 4 to 57) with a female sex frequency of 53.21%. The median age of the control participants was 29 years (range: 4–77) with a female sex frequency of 66.09%. The following proportions of abnormal biological indices were observed in SCA patients versus (vs.) controls, as follows: hyposthenuria: 35.3%vs.5.2% (p<0.001); glomerular hyperfiltration: 47.66%vs.19.75% (p<0.001), renal insufficiency: 5.47%vs.3.82% (p = 0.182); microalbuminuria: 42.38%vs.5.78% (p<0.001); proteinuria: 39.33%vs.4.62% (p<0.001); tubular proteinuria: 40.97%vs.4.73% (p<0.001) and microglucosuria: 22.5%vs.5.1% (p<0.001). This study shows a relatively high proportion of SCA nephropathy among patients living with SCA in Senegal. Microglucosuria, proteinuria, tubular proteinuria, microalbuminuria, hyposthenuria and glomerular hyperfiltration are the most prevalent biomarkers of nephropathy in this group of Senegalese patients with SCA. Public Library of Science 2022-11-21 /pmc/articles/PMC9678278/ /pubmed/36409722 http://dx.doi.org/10.1371/journal.pone.0273745 Text en © 2022 Ndour et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ndour, El Hadji Malick
Mnika, Khuthala
Tall, Fatou Guèye
Seck, Moussa
Ly, Indou Dème
Nembaware, Victoria
Mazandu, Gaston Kuzamunu
Sagna Bassène, Hélène Ange Thérèse
Dione, Rokhaya
Ndongo, Aliou Abdoulaye
Diop, Jean Pascal Demba
Barry, Nènè Oumou Kesso
Djité, Moustapha
Ndiaye Diallo, Rokhaya
Guèye, Papa Madièye
Diop, Saliou
Diagne, Ibrahima
Cissé, Aynina
Wonkam, Ambroise
Lopez Sall, Philomène
Biomarkers of sickle cell nephropathy in Senegal
title Biomarkers of sickle cell nephropathy in Senegal
title_full Biomarkers of sickle cell nephropathy in Senegal
title_fullStr Biomarkers of sickle cell nephropathy in Senegal
title_full_unstemmed Biomarkers of sickle cell nephropathy in Senegal
title_short Biomarkers of sickle cell nephropathy in Senegal
title_sort biomarkers of sickle cell nephropathy in senegal
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678278/
https://www.ncbi.nlm.nih.gov/pubmed/36409722
http://dx.doi.org/10.1371/journal.pone.0273745
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