Galactosyl- and glucosylsphingosine induce lysosomal membrane permeabilization and cell death in cancer cells

Isomeric lysosphingolipids, galactosylsphingosine (GalSph) and glucosylsphingosine (GlcSph), are present in only minute levels in healthy cells. Due to defects in their lysosomal hydrolysis, they accumulate at high levels and cause cytotoxicity in patients with Krabbe and Gaucher diseases, respectiv...

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Detalles Bibliográficos
Autores principales: Stahl-Meyer, Kamilla, Bilgin, Mesut, Holland, Lya K. K., Stahl-Meyer, Jonathan, Kirkegaard, Thomas, Petersen, Nikolaj Havnsøe Torp, Maeda, Kenji, Jäättelä, Marja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678304/
https://www.ncbi.nlm.nih.gov/pubmed/36409725
http://dx.doi.org/10.1371/journal.pone.0277058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678304/
https://www.ncbi.nlm.nih.gov/pubmed/36409725
http://dx.doi.org/10.1371/journal.pone.0277058

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