Cargando…

Galactosyl- and glucosylsphingosine induce lysosomal membrane permeabilization and cell death in cancer cells

Isomeric lysosphingolipids, galactosylsphingosine (GalSph) and glucosylsphingosine (GlcSph), are present in only minute levels in healthy cells. Due to defects in their lysosomal hydrolysis, they accumulate at high levels and cause cytotoxicity in patients with Krabbe and Gaucher diseases, respectiv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stahl-Meyer, Kamilla, Bilgin, Mesut, Holland, Lya K. K., Stahl-Meyer, Jonathan, Kirkegaard, Thomas, Petersen, Nikolaj Havnsøe Torp, Maeda, Kenji, Jäättelä, Marja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678304/ https://www.ncbi.nlm.nih.gov/pubmed/36409725 http://dx.doi.org/10.1371/journal.pone.0277058

Ejemplares similares

Lysosomal Changes in Mitosis
por: Stahl-Meyer, Jonathan, et al.
Publicado: (2022)

Ursolic Acid Impairs Cellular Lipid Homeostasis and Lysosomal Membrane Integrity in Breast Carcinoma Cells
por: Fogde, Ditte L., et al.
Publicado: (2022)

They Might Cut It—Lysosomes and Autophagy in Mitotic Progression
por: Hämälistö, Saara, et al.
Publicado: (2021)

Lysosomal Membrane Permeabilization Induces Cell Death in a Mitochondrion-dependent Fashion
por: Boya, Patricia, et al.
Publicado: (2003)

Pterostilbene-Induced Tumor Cytotoxicity: A Lysosomal Membrane Permeabilization-Dependent Mechanism
por: Mena, Salvador, et al.
Publicado: (2012)

Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization
por: Nylandsted, Jesper, et al.
Publicado: (2004)

Identification of Cytoskeleton-Associated Proteins Essential for Lysosomal Stability and Survival of Human Cancer Cells
por: Groth-Pedersen, Line, et al.
Publicado: (2012)

Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair
por: Radulovic, Maja, et al.
Publicado: (2022)

Ragulator—a multifaceted regulator of lysosomal signaling and trafficking
por: Colaço, Alexandria, et al.
Publicado: (2017)

Regulation of apoptosis-associated lysosomal membrane permeabilization
por: Johansson, Ann-Charlotte, et al.
Publicado: (2010)

Contribution of Particle-Induced Lysosomal Membrane Hyperpolarization to Lysosomal Membrane Permeabilization
por: Ziglari, Tahereh, et al.
Publicado: (2021)

Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish.
por: Lelieveld, Lindsey T., et al.
Publicado: (2022)

Lysosome as a Central Hub for Rewiring PH Homeostasis in Tumors
por: Chen, Ran, et al.
Publicado: (2020)

Deregulation of signalling in genetic conditions affecting the lysosomal metabolism of cholesterol and galactosyl-sphingolipids
por: Gowrishankar, S., et al.
Publicado: (2020)

Depletion of Kinesin 5B Affects Lysosomal Distribution and Stability and Induces Peri-Nuclear Accumulation of Autophagosomes in Cancer Cells
por: Cardoso, Carla M. P., et al.
Publicado: (2009)

MUC1c Regulates Cell Survival in Pancreatic Cancer by Preventing Lysosomal Permeabilization
por: Banerjee, Sulagna, et al.
Publicado: (2012)

Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of rapamycin complex 1
por: Srikanth, Manasa P., et al.
Publicado: (2021)

Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1
por: Vanwalleghem, Gilles, et al.
Publicado: (2015)

Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy
por: Halaby, Reginald
Publicado: (2021)

Optic Nerve Lipidomics Reveal Impaired Glucosylsphingosine Lipids Pathway in Glaucoma
por: Chauhan, Muhammad Zain, et al.
Publicado: (2019)

Increased Lysosomal Membrane Permeabilization in Oxidant-exposed Macrophages of Human Fibrotic Lungs
por: Persson, Hans L, et al.
Publicado: (2013)

Glucosylsphingosine Causes Hematological and Visceral Changes in Mice—Evidence for a Pathophysiological Role in Gaucher Disease
por: Lukas, Jan, et al.
Publicado: (2017)

PIG7 promotes leukemia cell chemosensitivity via lysosomal membrane permeabilization
por: Liu, Jiazhuo, et al.
Publicado: (2015)

Synthesis and biological activity of α-galactosyl ceramide KRN7000 and galactosyl (α1→2) galactosyl ceramide
por: Veerapen, Natacha, et al.
Publicado: (2009)

TFEB‐dependent lysosome biogenesis is required for senescence
por: Curnock, Rachel, et al.
Publicado: (2023)

Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation
por: Hämälistö, Saara, et al.
Publicado: (2020)

Effect of glutamate on lysosomal membrane permeabilization in primary cultured cortical neurons
por: YAN, MIN, et al.
Publicado: (2016)

Synthesis of an Hsp70 inhibitor and its assessment of lysosomal membrane permeabilization
por: Park, Sang-Hyun, et al.
Publicado: (2021)

Real-Time Monitoring of Lysosomal Membrane Permeabilization Using Acridine Orange
por: Eriksson, Ida, et al.
Publicado: (2023)

A self-assembled nanophotosensitizer targets lysosomes and induces lysosomal membrane permeabilization to enhance photodynamic therapy
por: Li, Youyou, et al.
Publicado: (2023)

(-)-Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization
por: LeGendre, Onica, et al.
Publicado: (2015)

(-)-Oleocanthal and (-)-oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells
por: Goren, Limor, et al.
Publicado: (2019)

Surface-associated antigen induces permeabilization of primary mouse B-cells and lysosome exocytosis facilitating antigen uptake and presentation to T-cells
por: Maeda, Fernando Y, et al.
Publicado: (2021)

Plasma Glucosylsphingosine in GBA1 Mutation Carriers with and without Parkinson's Disease
por: Surface, Matthew, et al.
Publicado: (2021)

DRAM Triggers Lysosomal Membrane Permeabilization and Cell Death in CD4(+) T Cells Infected with HIV
por: Laforge, Mireille, et al.
Publicado: (2013)

Lysosomal membrane permeabilization causes secretion of IL-1β in human vascular smooth muscle cells
por: Ono, Hiroaki, et al.
Publicado: (2018)

Changes of lysosomal membrane permeabilization and lipid metabolism in sidt2 deficient mice
por: Meng, Yu, et al.
Publicado: (2018)

Inhibition of Sp1 prevents ER homeostasis and causes cell death by lysosomal membrane permeabilization in pancreatic cancer
por: Dauer, Patricia, et al.
Publicado: (2017)

Suppressing UVRAG Induces Radiosensitivity by Triggering Lysosomal Membrane Permeabilization in Hypopharyngeal Squamous Cell Carcinoma
por: Wang, Jianwen, et al.
Publicado: (2020)

Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells
por: Cash, Timothy P., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_s4nj253t7tv2ktsg6av2nulc83