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Drosophila mechanical nociceptors preferentially sense localized poking
Mechanical nociception is an evolutionarily conserved sensory process required for the survival of living organisms. Previous studies have revealed much about the neural circuits and sensory molecules in mechanical nociception, but the cellular mechanisms adopted by nociceptors in force detection re...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678358/ https://www.ncbi.nlm.nih.gov/pubmed/36200757 http://dx.doi.org/10.7554/eLife.76574 |
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author | Liu, Zhen Wu, Meng-Hua Wang, Qi-Xuan Lin, Shao-Zhen Feng, Xi-Qiao Li, Bo Liang, Xin |
author_facet | Liu, Zhen Wu, Meng-Hua Wang, Qi-Xuan Lin, Shao-Zhen Feng, Xi-Qiao Li, Bo Liang, Xin |
author_sort | Liu, Zhen |
collection | PubMed |
description | Mechanical nociception is an evolutionarily conserved sensory process required for the survival of living organisms. Previous studies have revealed much about the neural circuits and sensory molecules in mechanical nociception, but the cellular mechanisms adopted by nociceptors in force detection remain elusive. To address this issue, we study the mechanosensation of a fly larval nociceptor (class IV da neurons, c4da) using a customized mechanical device. We find that c4da are sensitive to mN-scale forces and make uniform responses to the forces applied at different dendritic regions. Moreover, c4da showed a greater sensitivity to localized forces, consistent with them being able to detect the poking of sharp objects, such as wasp ovipositor. Further analysis reveals that high morphological complexity, mechanosensitivity to lateral tension and possibly also active signal propagation in dendrites contribute to the sensory features of c4da. In particular, we discover that Piezo and Ppk1/Ppk26, two key mechanosensory molecules, make differential but additive contributions to the mechanosensitivity of c4da. In all, our results provide updates into understanding how c4da process mechanical signals at the cellular level and reveal the contributions of key molecules. |
format | Online Article Text |
id | pubmed-9678358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-96783582022-11-22 Drosophila mechanical nociceptors preferentially sense localized poking Liu, Zhen Wu, Meng-Hua Wang, Qi-Xuan Lin, Shao-Zhen Feng, Xi-Qiao Li, Bo Liang, Xin eLife Neuroscience Mechanical nociception is an evolutionarily conserved sensory process required for the survival of living organisms. Previous studies have revealed much about the neural circuits and sensory molecules in mechanical nociception, but the cellular mechanisms adopted by nociceptors in force detection remain elusive. To address this issue, we study the mechanosensation of a fly larval nociceptor (class IV da neurons, c4da) using a customized mechanical device. We find that c4da are sensitive to mN-scale forces and make uniform responses to the forces applied at different dendritic regions. Moreover, c4da showed a greater sensitivity to localized forces, consistent with them being able to detect the poking of sharp objects, such as wasp ovipositor. Further analysis reveals that high morphological complexity, mechanosensitivity to lateral tension and possibly also active signal propagation in dendrites contribute to the sensory features of c4da. In particular, we discover that Piezo and Ppk1/Ppk26, two key mechanosensory molecules, make differential but additive contributions to the mechanosensitivity of c4da. In all, our results provide updates into understanding how c4da process mechanical signals at the cellular level and reveal the contributions of key molecules. eLife Sciences Publications, Ltd 2022-10-06 /pmc/articles/PMC9678358/ /pubmed/36200757 http://dx.doi.org/10.7554/eLife.76574 Text en © 2022, Liu, Wu et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Liu, Zhen Wu, Meng-Hua Wang, Qi-Xuan Lin, Shao-Zhen Feng, Xi-Qiao Li, Bo Liang, Xin Drosophila mechanical nociceptors preferentially sense localized poking |
title | Drosophila mechanical nociceptors preferentially sense localized poking |
title_full | Drosophila mechanical nociceptors preferentially sense localized poking |
title_fullStr | Drosophila mechanical nociceptors preferentially sense localized poking |
title_full_unstemmed | Drosophila mechanical nociceptors preferentially sense localized poking |
title_short | Drosophila mechanical nociceptors preferentially sense localized poking |
title_sort | drosophila mechanical nociceptors preferentially sense localized poking |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678358/ https://www.ncbi.nlm.nih.gov/pubmed/36200757 http://dx.doi.org/10.7554/eLife.76574 |
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