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Intracranial human recordings reveal association between neural activity and perceived intensity for the pain of others in the insula

Based on neuroimaging data, the insula is considered important for people to empathize with the pain of others. Here, we present intracranial electroencephalographic (iEEG) recordings and single-cell recordings from the human insula while seven epilepsy patients rated the intensity of a woman’s pain...

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Autores principales: Soyman, Efe, Bruls, Rune, Ioumpa, Kalliopi, Müller-Pinzler, Laura, Gallo, Selene, Qin, Chaoyi, van Straaten, Elisabeth CW, Self, Matthew W, Peters, Judith C, Possel, Jessy K, Onuki, Yoshiyuki, Baayen, Johannes C, Idema, Sander, Keysers, Christian, Gazzola, Valeria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678359/
https://www.ncbi.nlm.nih.gov/pubmed/36326213
http://dx.doi.org/10.7554/eLife.75197
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author Soyman, Efe
Bruls, Rune
Ioumpa, Kalliopi
Müller-Pinzler, Laura
Gallo, Selene
Qin, Chaoyi
van Straaten, Elisabeth CW
Self, Matthew W
Peters, Judith C
Possel, Jessy K
Onuki, Yoshiyuki
Baayen, Johannes C
Idema, Sander
Keysers, Christian
Gazzola, Valeria
author_facet Soyman, Efe
Bruls, Rune
Ioumpa, Kalliopi
Müller-Pinzler, Laura
Gallo, Selene
Qin, Chaoyi
van Straaten, Elisabeth CW
Self, Matthew W
Peters, Judith C
Possel, Jessy K
Onuki, Yoshiyuki
Baayen, Johannes C
Idema, Sander
Keysers, Christian
Gazzola, Valeria
author_sort Soyman, Efe
collection PubMed
description Based on neuroimaging data, the insula is considered important for people to empathize with the pain of others. Here, we present intracranial electroencephalographic (iEEG) recordings and single-cell recordings from the human insula while seven epilepsy patients rated the intensity of a woman’s painful experiences seen in short movie clips. Pain had to be deduced from seeing facial expressions or a hand being slapped by a belt. We found activity in the broadband 20–190 Hz range correlated with the trial-by-trial perceived intensity in the insula for both types of stimuli. Within the insula, some locations had activity correlating with perceived intensity for our facial expressions but not for our hand stimuli, others only for our hand but not our face stimuli, and others for both. The timing of responses to the sight of the hand being hit is best explained by kinematic information; that for our facial expressions, by shape information. Comparing the broadband activity in the iEEG signal with spiking activity from a small number of neurons and an fMRI experiment with similar stimuli revealed a consistent spatial organization, with stronger associations with intensity more anteriorly, while viewing the hand being slapped.
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spelling pubmed-96783592022-11-22 Intracranial human recordings reveal association between neural activity and perceived intensity for the pain of others in the insula Soyman, Efe Bruls, Rune Ioumpa, Kalliopi Müller-Pinzler, Laura Gallo, Selene Qin, Chaoyi van Straaten, Elisabeth CW Self, Matthew W Peters, Judith C Possel, Jessy K Onuki, Yoshiyuki Baayen, Johannes C Idema, Sander Keysers, Christian Gazzola, Valeria eLife Neuroscience Based on neuroimaging data, the insula is considered important for people to empathize with the pain of others. Here, we present intracranial electroencephalographic (iEEG) recordings and single-cell recordings from the human insula while seven epilepsy patients rated the intensity of a woman’s painful experiences seen in short movie clips. Pain had to be deduced from seeing facial expressions or a hand being slapped by a belt. We found activity in the broadband 20–190 Hz range correlated with the trial-by-trial perceived intensity in the insula for both types of stimuli. Within the insula, some locations had activity correlating with perceived intensity for our facial expressions but not for our hand stimuli, others only for our hand but not our face stimuli, and others for both. The timing of responses to the sight of the hand being hit is best explained by kinematic information; that for our facial expressions, by shape information. Comparing the broadband activity in the iEEG signal with spiking activity from a small number of neurons and an fMRI experiment with similar stimuli revealed a consistent spatial organization, with stronger associations with intensity more anteriorly, while viewing the hand being slapped. eLife Sciences Publications, Ltd 2022-11-03 /pmc/articles/PMC9678359/ /pubmed/36326213 http://dx.doi.org/10.7554/eLife.75197 Text en © 2022, Soyman, Bruls, Ioumpa et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Soyman, Efe
Bruls, Rune
Ioumpa, Kalliopi
Müller-Pinzler, Laura
Gallo, Selene
Qin, Chaoyi
van Straaten, Elisabeth CW
Self, Matthew W
Peters, Judith C
Possel, Jessy K
Onuki, Yoshiyuki
Baayen, Johannes C
Idema, Sander
Keysers, Christian
Gazzola, Valeria
Intracranial human recordings reveal association between neural activity and perceived intensity for the pain of others in the insula
title Intracranial human recordings reveal association between neural activity and perceived intensity for the pain of others in the insula
title_full Intracranial human recordings reveal association between neural activity and perceived intensity for the pain of others in the insula
title_fullStr Intracranial human recordings reveal association between neural activity and perceived intensity for the pain of others in the insula
title_full_unstemmed Intracranial human recordings reveal association between neural activity and perceived intensity for the pain of others in the insula
title_short Intracranial human recordings reveal association between neural activity and perceived intensity for the pain of others in the insula
title_sort intracranial human recordings reveal association between neural activity and perceived intensity for the pain of others in the insula
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678359/
https://www.ncbi.nlm.nih.gov/pubmed/36326213
http://dx.doi.org/10.7554/eLife.75197
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