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Applications of Metallic Nanoparticles in the Skin Cancer Treatment

Skin cancer is one of leading cancers globally, divided into two major categories including melanoma and nonmelanoma. Skin cancer is a global concern with an increasing trend, hence novel therapies are essential. The local treatment strategies play a key role in skin cancer therapy. Nanoparticles (N...

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Autores principales: Marzi, Mahrokh, Osanloo, Mahmoud, Vakil, Mohammad Kazem, Mansoori, Yaser, Ghasemian, Abdolmajid, Dehghan, Azizallah, Zarenezhad, Elham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678447/
https://www.ncbi.nlm.nih.gov/pubmed/36420097
http://dx.doi.org/10.1155/2022/2346941
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author Marzi, Mahrokh
Osanloo, Mahmoud
Vakil, Mohammad Kazem
Mansoori, Yaser
Ghasemian, Abdolmajid
Dehghan, Azizallah
Zarenezhad, Elham
author_facet Marzi, Mahrokh
Osanloo, Mahmoud
Vakil, Mohammad Kazem
Mansoori, Yaser
Ghasemian, Abdolmajid
Dehghan, Azizallah
Zarenezhad, Elham
author_sort Marzi, Mahrokh
collection PubMed
description Skin cancer is one of leading cancers globally, divided into two major categories including melanoma and nonmelanoma. Skin cancer is a global concern with an increasing trend, hence novel therapies are essential. The local treatment strategies play a key role in skin cancer therapy. Nanoparticles (NPs) exert potential applications in medicine with huge advantages and have the ability to overcome common chemotherapy problems. Recently, NPs have been used in nanomedicine as promising drug delivery systems. They can enhance the solubility of poorly water-soluble drugs, improve pharmacokinetic properties, modify bioavailability, and reduce drug metabolism. The high-efficient, nontoxic, low-cost, and specific cancer therapy is a promising goal, which can be achieved by the development of nanotechnology. Metallic NPs (MNPs) can act as important platforms. MNPs development seeks to enhance the therapeutic efficiency of medicines through site specificity, prevention of multidrug resistance, and effective delivery of therapeutic factors. MNPs are used as potential arms in the case of cancer recognition, such as Magnetic Resonance Imaging (MRI) and colloidal mediators for magnetic hyperthermia of cancer. The applications of MNPs in the cancer treatment studies are mostly due to their potential to carry a large dose of drug, resulting in a high concentration of anticancer drugs at the target site. Therefore, off-target toxicity and suffering side effects caused by high concentration of the drug in other parts of the body are avoided. MNPs have been applied as drug carriers for the of improvement of skin cancer treatment and drug delivery. The development of MNPs improves the results of many cancer treatments. Different types of NPs, such as inorganic and organic NPs have been investigated in vitro and in vivo for the skin cancer therapy. MNPs advantages mostly include biodegradability, electrostatic charge, good biocompatibility, high drug payload, and low toxicity. However, the use of controlled-release systems stimulated by electromagnetic waves, temperature, pH, and light improves the accumulation in tumor tissues and improves therapeutic outcomes. This study (2019-2022) is aimed at reviewing applications of MNPs in the skin cancer therapy.
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spelling pubmed-96784472022-11-22 Applications of Metallic Nanoparticles in the Skin Cancer Treatment Marzi, Mahrokh Osanloo, Mahmoud Vakil, Mohammad Kazem Mansoori, Yaser Ghasemian, Abdolmajid Dehghan, Azizallah Zarenezhad, Elham Biomed Res Int Review Article Skin cancer is one of leading cancers globally, divided into two major categories including melanoma and nonmelanoma. Skin cancer is a global concern with an increasing trend, hence novel therapies are essential. The local treatment strategies play a key role in skin cancer therapy. Nanoparticles (NPs) exert potential applications in medicine with huge advantages and have the ability to overcome common chemotherapy problems. Recently, NPs have been used in nanomedicine as promising drug delivery systems. They can enhance the solubility of poorly water-soluble drugs, improve pharmacokinetic properties, modify bioavailability, and reduce drug metabolism. The high-efficient, nontoxic, low-cost, and specific cancer therapy is a promising goal, which can be achieved by the development of nanotechnology. Metallic NPs (MNPs) can act as important platforms. MNPs development seeks to enhance the therapeutic efficiency of medicines through site specificity, prevention of multidrug resistance, and effective delivery of therapeutic factors. MNPs are used as potential arms in the case of cancer recognition, such as Magnetic Resonance Imaging (MRI) and colloidal mediators for magnetic hyperthermia of cancer. The applications of MNPs in the cancer treatment studies are mostly due to their potential to carry a large dose of drug, resulting in a high concentration of anticancer drugs at the target site. Therefore, off-target toxicity and suffering side effects caused by high concentration of the drug in other parts of the body are avoided. MNPs have been applied as drug carriers for the of improvement of skin cancer treatment and drug delivery. The development of MNPs improves the results of many cancer treatments. Different types of NPs, such as inorganic and organic NPs have been investigated in vitro and in vivo for the skin cancer therapy. MNPs advantages mostly include biodegradability, electrostatic charge, good biocompatibility, high drug payload, and low toxicity. However, the use of controlled-release systems stimulated by electromagnetic waves, temperature, pH, and light improves the accumulation in tumor tissues and improves therapeutic outcomes. This study (2019-2022) is aimed at reviewing applications of MNPs in the skin cancer therapy. Hindawi 2022-11-14 /pmc/articles/PMC9678447/ /pubmed/36420097 http://dx.doi.org/10.1155/2022/2346941 Text en Copyright © 2022 Mahrokh Marzi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Marzi, Mahrokh
Osanloo, Mahmoud
Vakil, Mohammad Kazem
Mansoori, Yaser
Ghasemian, Abdolmajid
Dehghan, Azizallah
Zarenezhad, Elham
Applications of Metallic Nanoparticles in the Skin Cancer Treatment
title Applications of Metallic Nanoparticles in the Skin Cancer Treatment
title_full Applications of Metallic Nanoparticles in the Skin Cancer Treatment
title_fullStr Applications of Metallic Nanoparticles in the Skin Cancer Treatment
title_full_unstemmed Applications of Metallic Nanoparticles in the Skin Cancer Treatment
title_short Applications of Metallic Nanoparticles in the Skin Cancer Treatment
title_sort applications of metallic nanoparticles in the skin cancer treatment
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678447/
https://www.ncbi.nlm.nih.gov/pubmed/36420097
http://dx.doi.org/10.1155/2022/2346941
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