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A new predictive tool consolidating CURB-65 with procalcitonin and albumin to assess short-term mortality in hospitalized elderly patients with infectious disease: A retrospective study of a patient cohort

Hospitalized elderly patients are often at risk of life-threatening infectious diseases such as pneumonia and urinary tract infection, thus diagnostic tools for bacterial infections are demanded. We developed a new predictive tool consolidating modified CURB-65, procalcitonin (PCT) and albumin (Alb)...

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Autores principales: Higashikawa, Toshihiro, Ito, Tomohiko, Mizuno, Takuro, Ishigami, Keiichirou, Kuroki, Kengo, Maekawa, Naoto, Usuda, Daisuke, Nakao, Shinichiro, Hamada, Kazu, Takagi, Susumu, Terada, Nao, Takeshima, Kento, Yamada, Shinya, Sangen, Ryusho, Izumida, Toshihide, Kiyosawa, Jun, Saito, Atsushi, Iguchi, Masaharu, Wato, Hiroyuki, Nakahashi, Takeshi, Kasamaki, Yuji, Fukuda, Akihiro, Kanda, Tsugiyasu, Okuro, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678497/
https://www.ncbi.nlm.nih.gov/pubmed/36401412
http://dx.doi.org/10.1097/MD.0000000000031614
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author Higashikawa, Toshihiro
Ito, Tomohiko
Mizuno, Takuro
Ishigami, Keiichirou
Kuroki, Kengo
Maekawa, Naoto
Usuda, Daisuke
Nakao, Shinichiro
Hamada, Kazu
Takagi, Susumu
Terada, Nao
Takeshima, Kento
Yamada, Shinya
Sangen, Ryusho
Izumida, Toshihide
Kiyosawa, Jun
Saito, Atsushi
Iguchi, Masaharu
Wato, Hiroyuki
Nakahashi, Takeshi
Kasamaki, Yuji
Fukuda, Akihiro
Kanda, Tsugiyasu
Okuro, Masashi
author_facet Higashikawa, Toshihiro
Ito, Tomohiko
Mizuno, Takuro
Ishigami, Keiichirou
Kuroki, Kengo
Maekawa, Naoto
Usuda, Daisuke
Nakao, Shinichiro
Hamada, Kazu
Takagi, Susumu
Terada, Nao
Takeshima, Kento
Yamada, Shinya
Sangen, Ryusho
Izumida, Toshihide
Kiyosawa, Jun
Saito, Atsushi
Iguchi, Masaharu
Wato, Hiroyuki
Nakahashi, Takeshi
Kasamaki, Yuji
Fukuda, Akihiro
Kanda, Tsugiyasu
Okuro, Masashi
author_sort Higashikawa, Toshihiro
collection PubMed
description Hospitalized elderly patients are often at risk of life-threatening infectious diseases such as pneumonia and urinary tract infection, thus diagnostic tools for bacterial infections are demanded. We developed a new predictive tool consolidating modified CURB-65, procalcitonin (PCT) and albumin (Alb). METHOD: This is a retrospective study. Modified CURB-65 (mCURB-65) score, PCT, Alb, and various cardiovascular/respiratory/renal functions were measured. Survival analyses were conducted to assess 30-days mortality of elderly patients using mCURB-65 score, PCT and Alb. The consolidated scores were compared with the number of patients died. RESULTS: There were 445 elderly patients included. Kaplan–Meier survival curves showed significant differences between the high and low groups of mCURB-65, PCT and Alb (log-rank test, P < .001). Cox proportional regression showed that the hazard ratios (95% confidence intervals) for high mCURB-65, high Alb, and high PCT were all significant, 1.95 (1.24–3.05), 0.50 (0.32–0.77), and 2.09 (1.32–3.31), respectively. The consolidated scores showed tendency of increase with proportion of the number of patients died. CONCLUSIONS: The consolidated score consisted of mCURB-65, PCT and Alb can be a useful tool to predict short-term mortality of the hospitalized elderly patients with infectious disease.
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spelling pubmed-96784972022-11-22 A new predictive tool consolidating CURB-65 with procalcitonin and albumin to assess short-term mortality in hospitalized elderly patients with infectious disease: A retrospective study of a patient cohort Higashikawa, Toshihiro Ito, Tomohiko Mizuno, Takuro Ishigami, Keiichirou Kuroki, Kengo Maekawa, Naoto Usuda, Daisuke Nakao, Shinichiro Hamada, Kazu Takagi, Susumu Terada, Nao Takeshima, Kento Yamada, Shinya Sangen, Ryusho Izumida, Toshihide Kiyosawa, Jun Saito, Atsushi Iguchi, Masaharu Wato, Hiroyuki Nakahashi, Takeshi Kasamaki, Yuji Fukuda, Akihiro Kanda, Tsugiyasu Okuro, Masashi Medicine (Baltimore) 4600 Hospitalized elderly patients are often at risk of life-threatening infectious diseases such as pneumonia and urinary tract infection, thus diagnostic tools for bacterial infections are demanded. We developed a new predictive tool consolidating modified CURB-65, procalcitonin (PCT) and albumin (Alb). METHOD: This is a retrospective study. Modified CURB-65 (mCURB-65) score, PCT, Alb, and various cardiovascular/respiratory/renal functions were measured. Survival analyses were conducted to assess 30-days mortality of elderly patients using mCURB-65 score, PCT and Alb. The consolidated scores were compared with the number of patients died. RESULTS: There were 445 elderly patients included. Kaplan–Meier survival curves showed significant differences between the high and low groups of mCURB-65, PCT and Alb (log-rank test, P < .001). Cox proportional regression showed that the hazard ratios (95% confidence intervals) for high mCURB-65, high Alb, and high PCT were all significant, 1.95 (1.24–3.05), 0.50 (0.32–0.77), and 2.09 (1.32–3.31), respectively. The consolidated scores showed tendency of increase with proportion of the number of patients died. CONCLUSIONS: The consolidated score consisted of mCURB-65, PCT and Alb can be a useful tool to predict short-term mortality of the hospitalized elderly patients with infectious disease. Lippincott Williams & Wilkins 2022-11-18 /pmc/articles/PMC9678497/ /pubmed/36401412 http://dx.doi.org/10.1097/MD.0000000000031614 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 4600
Higashikawa, Toshihiro
Ito, Tomohiko
Mizuno, Takuro
Ishigami, Keiichirou
Kuroki, Kengo
Maekawa, Naoto
Usuda, Daisuke
Nakao, Shinichiro
Hamada, Kazu
Takagi, Susumu
Terada, Nao
Takeshima, Kento
Yamada, Shinya
Sangen, Ryusho
Izumida, Toshihide
Kiyosawa, Jun
Saito, Atsushi
Iguchi, Masaharu
Wato, Hiroyuki
Nakahashi, Takeshi
Kasamaki, Yuji
Fukuda, Akihiro
Kanda, Tsugiyasu
Okuro, Masashi
A new predictive tool consolidating CURB-65 with procalcitonin and albumin to assess short-term mortality in hospitalized elderly patients with infectious disease: A retrospective study of a patient cohort
title A new predictive tool consolidating CURB-65 with procalcitonin and albumin to assess short-term mortality in hospitalized elderly patients with infectious disease: A retrospective study of a patient cohort
title_full A new predictive tool consolidating CURB-65 with procalcitonin and albumin to assess short-term mortality in hospitalized elderly patients with infectious disease: A retrospective study of a patient cohort
title_fullStr A new predictive tool consolidating CURB-65 with procalcitonin and albumin to assess short-term mortality in hospitalized elderly patients with infectious disease: A retrospective study of a patient cohort
title_full_unstemmed A new predictive tool consolidating CURB-65 with procalcitonin and albumin to assess short-term mortality in hospitalized elderly patients with infectious disease: A retrospective study of a patient cohort
title_short A new predictive tool consolidating CURB-65 with procalcitonin and albumin to assess short-term mortality in hospitalized elderly patients with infectious disease: A retrospective study of a patient cohort
title_sort new predictive tool consolidating curb-65 with procalcitonin and albumin to assess short-term mortality in hospitalized elderly patients with infectious disease: a retrospective study of a patient cohort
topic 4600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678497/
https://www.ncbi.nlm.nih.gov/pubmed/36401412
http://dx.doi.org/10.1097/MD.0000000000031614
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