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Prognostic value of tumor size in thymic epithelial tumors: A systematic review and meta-analysis

Whether the size of thymic epithelial tumors (TETs) has an impact on prognosis has long been a controversial issue. Our study was designed to investigate the value of tumor size in the prognosis (overall survival (OS) and relapse-free survival) of patients with TETs. METHODS: We searched the databas...

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Autores principales: Shao, Yifeng, Tang, Mingbo, Fang, Linan, Wei, Shixiong, Gao, Xinliang, Liu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678511/
https://www.ncbi.nlm.nih.gov/pubmed/36401408
http://dx.doi.org/10.1097/MD.0000000000031741
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author Shao, Yifeng
Tang, Mingbo
Fang, Linan
Wei, Shixiong
Gao, Xinliang
Liu, Wei
author_facet Shao, Yifeng
Tang, Mingbo
Fang, Linan
Wei, Shixiong
Gao, Xinliang
Liu, Wei
author_sort Shao, Yifeng
collection PubMed
description Whether the size of thymic epithelial tumors (TETs) has an impact on prognosis has long been a controversial issue. Our study was designed to investigate the value of tumor size in the prognosis (overall survival (OS) and relapse-free survival) of patients with TETs. METHODS: We searched the databases such as PubMed, EMBASE, Web of Science, and clinical trials registration system for articles illustrating the impact of tumor size on survival data in TETs patients. We did a meta-analysis for OS and relapse-free survival. RESULTS: We recruited 9 studies in our meta-analysis. Our study illustrates that TETs patients with small tumor size had better relapse-free survival (hazard ratio = 1.66, 95% confidence interval 1.18–2.35, P = .004) and OS (hazard ratio = 1.93, 95% confidence interval 1.30–2.80, P = .001) in comparison to patients with large tumor size. CONCLUSIONS: In conclusion, the results of our meta-analysis showed that TET size was significantly associated with overall and relapse-free survival of patients, with relatively small tumors tending to have a better prognosis.
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spelling pubmed-96785112022-11-22 Prognostic value of tumor size in thymic epithelial tumors: A systematic review and meta-analysis Shao, Yifeng Tang, Mingbo Fang, Linan Wei, Shixiong Gao, Xinliang Liu, Wei Medicine (Baltimore) 5700 Whether the size of thymic epithelial tumors (TETs) has an impact on prognosis has long been a controversial issue. Our study was designed to investigate the value of tumor size in the prognosis (overall survival (OS) and relapse-free survival) of patients with TETs. METHODS: We searched the databases such as PubMed, EMBASE, Web of Science, and clinical trials registration system for articles illustrating the impact of tumor size on survival data in TETs patients. We did a meta-analysis for OS and relapse-free survival. RESULTS: We recruited 9 studies in our meta-analysis. Our study illustrates that TETs patients with small tumor size had better relapse-free survival (hazard ratio = 1.66, 95% confidence interval 1.18–2.35, P = .004) and OS (hazard ratio = 1.93, 95% confidence interval 1.30–2.80, P = .001) in comparison to patients with large tumor size. CONCLUSIONS: In conclusion, the results of our meta-analysis showed that TET size was significantly associated with overall and relapse-free survival of patients, with relatively small tumors tending to have a better prognosis. Lippincott Williams & Wilkins 2022-11-18 /pmc/articles/PMC9678511/ /pubmed/36401408 http://dx.doi.org/10.1097/MD.0000000000031741 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 5700
Shao, Yifeng
Tang, Mingbo
Fang, Linan
Wei, Shixiong
Gao, Xinliang
Liu, Wei
Prognostic value of tumor size in thymic epithelial tumors: A systematic review and meta-analysis
title Prognostic value of tumor size in thymic epithelial tumors: A systematic review and meta-analysis
title_full Prognostic value of tumor size in thymic epithelial tumors: A systematic review and meta-analysis
title_fullStr Prognostic value of tumor size in thymic epithelial tumors: A systematic review and meta-analysis
title_full_unstemmed Prognostic value of tumor size in thymic epithelial tumors: A systematic review and meta-analysis
title_short Prognostic value of tumor size in thymic epithelial tumors: A systematic review and meta-analysis
title_sort prognostic value of tumor size in thymic epithelial tumors: a systematic review and meta-analysis
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678511/
https://www.ncbi.nlm.nih.gov/pubmed/36401408
http://dx.doi.org/10.1097/MD.0000000000031741
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