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TKIs combined with chemotherapy followed by allo-HSCT in Philadelphia chromosome-positive myelodysplastic syndrome: A case report and literature review

Philadelphia chromosome (Ph) positive myelodysplastic syndrome (MDS) is a very rare disease. At present, the specific role of Ph in MDS is not clear, but such patients seem to have a poor prognosis, so the disease deserves attention. Here, we describe the history of a woman with Ph-positive MDS and...

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Autores principales: Qi, Shasha, Wang, Feiqing, Liu, Yang, Zhao, Jiangyuan, Wang, Yan, Huang, Songsong, Yang, Wenxiu, Li, Yanling, Shen, Yong, Zhang, Chike, Zhao, Jianing, Yang, Xu, Gao, Rui, Chen, Ying, Zhao, Peng, Zhang, Fengqi, Huang, Yi, Zhao, Mei, Wang, Ping, Zhang, Yan, Dou, Hanbo, Wang, Jishi, Li, Yanju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678630/
https://www.ncbi.nlm.nih.gov/pubmed/36401464
http://dx.doi.org/10.1097/MD.0000000000031874
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author Qi, Shasha
Wang, Feiqing
Liu, Yang
Zhao, Jiangyuan
Wang, Yan
Huang, Songsong
Yang, Wenxiu
Li, Yanling
Shen, Yong
Zhang, Chike
Zhao, Jianing
Yang, Xu
Gao, Rui
Chen, Ying
Zhao, Peng
Zhang, Fengqi
Huang, Yi
Zhao, Mei
Wang, Ping
Zhang, Yan
Dou, Hanbo
Wang, Jishi
Li, Yanju
author_facet Qi, Shasha
Wang, Feiqing
Liu, Yang
Zhao, Jiangyuan
Wang, Yan
Huang, Songsong
Yang, Wenxiu
Li, Yanling
Shen, Yong
Zhang, Chike
Zhao, Jianing
Yang, Xu
Gao, Rui
Chen, Ying
Zhao, Peng
Zhang, Fengqi
Huang, Yi
Zhao, Mei
Wang, Ping
Zhang, Yan
Dou, Hanbo
Wang, Jishi
Li, Yanju
author_sort Qi, Shasha
collection PubMed
description Philadelphia chromosome (Ph) positive myelodysplastic syndrome (MDS) is a very rare disease. At present, the specific role of Ph in MDS is not clear, but such patients seem to have a poor prognosis, so the disease deserves attention. Here, we describe the history of a woman with Ph-positive MDS and perform a systematic review of related literature. PATIENT CONCERNS AND DIAGNOSIS: We report a 38-year-old woman with Ph-positive MDS. INTERVENTIONS AND OUTCOMES: She received chemotherapy with decitabine, cytarabine, aclarubicin, and granulocyte colony-stimulating factor (DCAG) combined with imatinib mesylate and achieved a bone marrow remission. She then underwent an allogeneic hematopoietic stem cell transplant. The condition is good and no recurrence of the disease has been observed. CONCLUSION: Ph-positive MDS is a very rare disease. Ph may aid in the malignant progression of MDS leaving such patients with a very poor prognosis. Tyrosine kinase inhibitors (TKIs) plus chemotherapy followed by allogeneic hematopoietic stem cell transplantation has provided these patients with satisfactory outcomes.
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spelling pubmed-96786302022-11-23 TKIs combined with chemotherapy followed by allo-HSCT in Philadelphia chromosome-positive myelodysplastic syndrome: A case report and literature review Qi, Shasha Wang, Feiqing Liu, Yang Zhao, Jiangyuan Wang, Yan Huang, Songsong Yang, Wenxiu Li, Yanling Shen, Yong Zhang, Chike Zhao, Jianing Yang, Xu Gao, Rui Chen, Ying Zhao, Peng Zhang, Fengqi Huang, Yi Zhao, Mei Wang, Ping Zhang, Yan Dou, Hanbo Wang, Jishi Li, Yanju Medicine (Baltimore) 4800 Philadelphia chromosome (Ph) positive myelodysplastic syndrome (MDS) is a very rare disease. At present, the specific role of Ph in MDS is not clear, but such patients seem to have a poor prognosis, so the disease deserves attention. Here, we describe the history of a woman with Ph-positive MDS and perform a systematic review of related literature. PATIENT CONCERNS AND DIAGNOSIS: We report a 38-year-old woman with Ph-positive MDS. INTERVENTIONS AND OUTCOMES: She received chemotherapy with decitabine, cytarabine, aclarubicin, and granulocyte colony-stimulating factor (DCAG) combined with imatinib mesylate and achieved a bone marrow remission. She then underwent an allogeneic hematopoietic stem cell transplant. The condition is good and no recurrence of the disease has been observed. CONCLUSION: Ph-positive MDS is a very rare disease. Ph may aid in the malignant progression of MDS leaving such patients with a very poor prognosis. Tyrosine kinase inhibitors (TKIs) plus chemotherapy followed by allogeneic hematopoietic stem cell transplantation has provided these patients with satisfactory outcomes. Lippincott Williams & Wilkins 2022-11-18 /pmc/articles/PMC9678630/ /pubmed/36401464 http://dx.doi.org/10.1097/MD.0000000000031874 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 4800
Qi, Shasha
Wang, Feiqing
Liu, Yang
Zhao, Jiangyuan
Wang, Yan
Huang, Songsong
Yang, Wenxiu
Li, Yanling
Shen, Yong
Zhang, Chike
Zhao, Jianing
Yang, Xu
Gao, Rui
Chen, Ying
Zhao, Peng
Zhang, Fengqi
Huang, Yi
Zhao, Mei
Wang, Ping
Zhang, Yan
Dou, Hanbo
Wang, Jishi
Li, Yanju
TKIs combined with chemotherapy followed by allo-HSCT in Philadelphia chromosome-positive myelodysplastic syndrome: A case report and literature review
title TKIs combined with chemotherapy followed by allo-HSCT in Philadelphia chromosome-positive myelodysplastic syndrome: A case report and literature review
title_full TKIs combined with chemotherapy followed by allo-HSCT in Philadelphia chromosome-positive myelodysplastic syndrome: A case report and literature review
title_fullStr TKIs combined with chemotherapy followed by allo-HSCT in Philadelphia chromosome-positive myelodysplastic syndrome: A case report and literature review
title_full_unstemmed TKIs combined with chemotherapy followed by allo-HSCT in Philadelphia chromosome-positive myelodysplastic syndrome: A case report and literature review
title_short TKIs combined with chemotherapy followed by allo-HSCT in Philadelphia chromosome-positive myelodysplastic syndrome: A case report and literature review
title_sort tkis combined with chemotherapy followed by allo-hsct in philadelphia chromosome-positive myelodysplastic syndrome: a case report and literature review
topic 4800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678630/
https://www.ncbi.nlm.nih.gov/pubmed/36401464
http://dx.doi.org/10.1097/MD.0000000000031874
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