Cargando…

High expression of prolyl 4-hydroxylase subunit alpha-2 in lung adenocarcinoma indicates poor prognosis

OBJECTIVE: To analyze the Prolyl 4-Hydroxylase subunit Alpha-2 (P4HA2) expression in Lung Adenocarcinoma (LAUD). METHODS: The authors assessed P4HA2 expression in the LUAD tumor ecosystem using single-cell analysis. The authors analyzed the relationship between P4HA2 expression and clinical features...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Xiao-Hong, Sang, Die, Zhang, Yu-Rong, Yuan, Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678672/ https://www.ncbi.nlm.nih.gov/pubmed/36403427 http://dx.doi.org/10.1016/j.clinsp.2022.100123

Ejemplares similares

Decreased expression of prolyl hydroxylase 1 is associated with poor prognosis in colorectal cancers
por: Melling, Nathaniel, et al.
Publicado: (2023)

Thrombospondin-1 and prolyl 4-hydroxylase subunit alpha 3 as potential biomarkers of salivary gland fibrosis
por: Zhang, Zijian, et al.
Publicado: (2023)

Prolyl-4-Hydroxylase α Subunit 2 as a Novel Potential Biomarker for Predicting the Prognosis of Epithelial Ovarian Carcinoma
por: Zhang, Haibo, et al.
Publicado: (2021)

High Prolyl 4-Hydroxylase Subunit Alpha 3 Expression as an Independent Prognostic Biomarker and Correlated With Immune Infiltration in Gastric Cancer
por: Niu, Xiaoji, et al.
Publicado: (2022)

Function and expression of prolyl hydroxylase 3 in cancers
por: Liu, Qiu-long, et al.
Publicado: (2013)

Prolyl 4‐hydroxylase subunit alpha 1 (P4HA1) is a biomarker of poor prognosis in primary melanomas, and its depletion inhibits melanoma cell invasion and disrupts tumor blood vessel walls
por: Eriksson, Johanna, et al.
Publicado: (2020)

Suppression of collagen IV alpha‐2 subunit by prolyl hydroxylase domain inhibition via hypoxia‐inducible factor‐1 in chronic kidney disease
por: Sanaei‐Ardekani, Mohammad, et al.
Publicado: (2021)

The role of HIF prolyl hydroxylases in tumour growth
por: Jokilehto, Terhi, et al.
Publicado: (2010)

Minoxidil Induction of VEGF Is Mediated by Inhibition of HIF-Prolyl Hydroxylase
por: Yum, Soohwan, et al.
Publicado: (2017)

Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition
por: Xiong, Gaofeng, et al.
Publicado: (2014)

Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase
por: Longbotham, James E., et al.
Publicado: (2015)

Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat
por: Figg, William D., et al.
Publicado: (2021)

Role of prolyl hydroxylase domain proteins in bone metabolism
por: Wolf, David, et al.
Publicado: (2022)

Prolyl 4-hydroxylase alpha 1 protein expression risk-stratifies early stage colorectal cancer
por: Tanaka, Atsushi, et al.
Publicado: (2020)

Prolyl-4-hydroxylase Α subunit 2 (P4HA2) expression is a predictor of poor outcome in breast ductal carcinoma in situ (DCIS)
por: Toss, Michael S., et al.
Publicado: (2018)

Relative Contribution of Prolyl Hydroxylase-Dependent and -Independent Degradation of HIF-1alpha by Proteasomal Pathways in Cerebral Ischemia
por: Badawi, Yomna, et al.
Publicado: (2017)

Prolyl hydroxylase domain protein 3 and asparaginyl hydroxylase factor inhibiting HIF-1 levels are predictive of tumoral behavior and prognosis in hepatocellular carcinoma
por: Ma, Mingyang, et al.
Publicado: (2017)

Prolyl 4 Hydroxylase: A Critical Target in the Pathophysiology of Diseases
por: Kant, Ravi, et al.
Publicado: (2013)

The collagen prolyl hydroxylases are novel transcriptionally silenced genes in lymphoma
por: Hatzimichael, E, et al.
Publicado: (2012)

Prolyl-hydroxylase 3: evolving roles for an ancient signaling protein
por: Place, Trenton L, et al.
Publicado: (2013)

Role of prolyl hydroxylase domain proteins in the regulation of insulin secretion
por: Huang, Mei, et al.
Publicado: (2016)

Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism
por: Yang, Ming, et al.
Publicado: (2014)

An Arabidopsis Prolyl 4 Hydroxylase Is Involved in the Low Oxygen Response
por: Konkina, Anna, et al.
Publicado: (2021)

Prolyl 3-Hydroxylase 2 Is a Molecular Player of Angiogenesis
por: Pignata, Paola, et al.
Publicado: (2021)

Microbiota-derived butyrate is an endogenous HIF prolyl hydroxylase inhibitor
por: Wang, Ruth X., et al.
Publicado: (2021)

Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses
por: Strowitzki, Moritz J., et al.
Publicado: (2021)

Role of prolyl hydroxylase/HIF-1 signaling in vascular calcification
por: Negri, Armando Luis
Publicado: (2022)

Genetically proxied therapeutic prolyl-hydroxylase inhibition and cardiovascular risk
por: Harlow, Charli E, et al.
Publicado: (2022)

Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors and Iron Metabolism
por: Ogawa, Chie, et al.
Publicado: (2023)

Hypoxia inducible factor prolyl hydroxylases in inflammatory bowel disease
por: Lun, Jie, et al.
Publicado: (2023)

High expression of DARS2 indicates poor prognosis in lung adenocarcinoma
por: Jiang, Yingfeng, et al.
Publicado: (2022)

Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor
por: Kiriakidis, Serafim, et al.
Publicado: (2017)

Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma
por: Leppänen, Joni, et al.
Publicado: (2018)

High levels of serum glypican‐1 indicate poor prognosis in pancreatic ductal adenocarcinoma
por: Zhou, Cong‐ya, et al.
Publicado: (2018)

Prognostic value of hypoxia-inducible factor-1 alpha and prolyl 4-hydroxylase beta polypeptide overexpression in gastric cancer
por: Zhang, Jun, et al.
Publicado: (2018)

Involvement of Prolyl Hydroxylase Domain Protein in the Rosiglitazone-Induced Suppression of Osteoblast Differentiation
por: Kang, Ju-Hee, et al.
Publicado: (2015)

Sandwich ELISA for quantitative detection of human collagen prolyl 4-hydroxylase
por: Osmekhina, Ekaterina, et al.
Publicado: (2010)

Human prolyl hydroxylase expression in uterine leiomyoma during the menstrual cycle
por: Iwahashi, Masaaki, et al.
Publicado: (2012)

HIF-independent role of prolyl hydroxylases in the cellular response to amino acids
por: Durán, R V, et al.
Publicado: (2013)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
por: Chowdhury, Rasheduzzaman, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_egqqgl6d8lki77bb1k6caik8a4