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Prevalence of Amyloid Deposition in Patients Undergoing Surgical Repair of Traumatic Distal Biceps Tendon Ruptures
PURPOSE: As many as one-third of patients with heart failure secondary to systemic, wild-type transthyretin amyloidosis have an associated distal biceps tendon (DBT) rupture. Our purpose was to identify the prevalence of amyloid deposition in patients undergoing operative repair of acute traumatic D...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678722/ https://www.ncbi.nlm.nih.gov/pubmed/36425370 http://dx.doi.org/10.1016/j.jhsg.2022.08.008 |
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author | Baylor, Jessica L. Nester, Jordan R. Olsen, Hans P. Pallis, Mark Akoon, Anil Grandizio, Louis C. |
author_facet | Baylor, Jessica L. Nester, Jordan R. Olsen, Hans P. Pallis, Mark Akoon, Anil Grandizio, Louis C. |
author_sort | Baylor, Jessica L. |
collection | PubMed |
description | PURPOSE: As many as one-third of patients with heart failure secondary to systemic, wild-type transthyretin amyloidosis have an associated distal biceps tendon (DBT) rupture. Our purpose was to identify the prevalence of amyloid deposition in patients undergoing operative repair of acute traumatic DBT ruptures. METHODS: In this prospective investigation, a consecutive series of patients who underwent repair of an acute traumatic DBT rupture underwent a tendon biopsy to assess for amyloid deposition. All specimens were viewed under gross microscopy by a board-certified pathologist. For initial screening, either Congo red or Thioflavin-T immunohistochemistry analysis was conducted to determine amyloid status. If staining was positive for amyloid deposition using either technique, the tissue sample was sent to an outside facility for specific amyloid protein identification through liquid chromatography–tandem mass spectrometry. Baseline demographics were also recorded for each patient. RESULTS: A total of 30 patients who underwent biopsy and repair of an acute DBT rupture were included. The mean age was 48 years, and all patients were men. Seven (23%) patients had a history of carpal tunnel syndrome, and 1 (3%) patient had evidence of heart failure at the time of surgery. One (3%) patient had evidence of amyloid deposition in the DBT, which was confirmed using liquid chromatography–tandem mass spectrometry. CONCLUSIONS: Although one-third of patients with heart failure secondary to cardiac amyloidosis have an associated DBT rupture, younger patients with acute traumatic DBT ruptures do not appear to be uniquely at risk for amyloid deposition at the time of DBT repair. Larger registry studies may be necessary to define the risk of developing cardiac amyloidosis years after sustaining an acute DBT rupture. TYPE OF STUDY/LEVEL OF EVIDENCE: Prognostic IV. |
format | Online Article Text |
id | pubmed-9678722 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-96787222022-11-23 Prevalence of Amyloid Deposition in Patients Undergoing Surgical Repair of Traumatic Distal Biceps Tendon Ruptures Baylor, Jessica L. Nester, Jordan R. Olsen, Hans P. Pallis, Mark Akoon, Anil Grandizio, Louis C. J Hand Surg Glob Online Original Research PURPOSE: As many as one-third of patients with heart failure secondary to systemic, wild-type transthyretin amyloidosis have an associated distal biceps tendon (DBT) rupture. Our purpose was to identify the prevalence of amyloid deposition in patients undergoing operative repair of acute traumatic DBT ruptures. METHODS: In this prospective investigation, a consecutive series of patients who underwent repair of an acute traumatic DBT rupture underwent a tendon biopsy to assess for amyloid deposition. All specimens were viewed under gross microscopy by a board-certified pathologist. For initial screening, either Congo red or Thioflavin-T immunohistochemistry analysis was conducted to determine amyloid status. If staining was positive for amyloid deposition using either technique, the tissue sample was sent to an outside facility for specific amyloid protein identification through liquid chromatography–tandem mass spectrometry. Baseline demographics were also recorded for each patient. RESULTS: A total of 30 patients who underwent biopsy and repair of an acute DBT rupture were included. The mean age was 48 years, and all patients were men. Seven (23%) patients had a history of carpal tunnel syndrome, and 1 (3%) patient had evidence of heart failure at the time of surgery. One (3%) patient had evidence of amyloid deposition in the DBT, which was confirmed using liquid chromatography–tandem mass spectrometry. CONCLUSIONS: Although one-third of patients with heart failure secondary to cardiac amyloidosis have an associated DBT rupture, younger patients with acute traumatic DBT ruptures do not appear to be uniquely at risk for amyloid deposition at the time of DBT repair. Larger registry studies may be necessary to define the risk of developing cardiac amyloidosis years after sustaining an acute DBT rupture. TYPE OF STUDY/LEVEL OF EVIDENCE: Prognostic IV. Elsevier 2022-09-16 /pmc/articles/PMC9678722/ /pubmed/36425370 http://dx.doi.org/10.1016/j.jhsg.2022.08.008 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research Baylor, Jessica L. Nester, Jordan R. Olsen, Hans P. Pallis, Mark Akoon, Anil Grandizio, Louis C. Prevalence of Amyloid Deposition in Patients Undergoing Surgical Repair of Traumatic Distal Biceps Tendon Ruptures |
title | Prevalence of Amyloid Deposition in Patients Undergoing Surgical Repair of Traumatic Distal Biceps Tendon Ruptures |
title_full | Prevalence of Amyloid Deposition in Patients Undergoing Surgical Repair of Traumatic Distal Biceps Tendon Ruptures |
title_fullStr | Prevalence of Amyloid Deposition in Patients Undergoing Surgical Repair of Traumatic Distal Biceps Tendon Ruptures |
title_full_unstemmed | Prevalence of Amyloid Deposition in Patients Undergoing Surgical Repair of Traumatic Distal Biceps Tendon Ruptures |
title_short | Prevalence of Amyloid Deposition in Patients Undergoing Surgical Repair of Traumatic Distal Biceps Tendon Ruptures |
title_sort | prevalence of amyloid deposition in patients undergoing surgical repair of traumatic distal biceps tendon ruptures |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678722/ https://www.ncbi.nlm.nih.gov/pubmed/36425370 http://dx.doi.org/10.1016/j.jhsg.2022.08.008 |
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