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Intracranial delivery of antisense locked nucleic acids for silencing microRNAs in the mouse brain
Antisense locked nucleic acid (LNA) technology has been widely used for silencing microRNAs with enhanced specificity and efficiency. In this protocol, we first describe the procedure for targeted intracranial delivery of LNAs to silence microRNAs specifically in the mouse brain. We then detail the...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678759/ https://www.ncbi.nlm.nih.gov/pubmed/36595897 http://dx.doi.org/10.1016/j.xpro.2022.101836 |