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Cardio-protective effect of Cocculus hirsutus in experimental hypertension in rats

BACKGROUND: Ayurdvedic derived medicines are most promising and effective in the treatment of several cardiovascular diseases. Cocculus hirsutus (CH) has been reported for broad spectrum of activities like anticancer, antidiabetic, antioxidant, cardiotonic and hypotensive etc. OBJECTIVES: The presen...

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Autores principales: Gunjegaonkar, S.M., Khakal, V.R., Joshi, A.A., Nargund, S.L., Shinde, S.D., Khan, N.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678779/
https://www.ncbi.nlm.nih.gov/pubmed/36403501
http://dx.doi.org/10.1016/j.jaim.2022.100652
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author Gunjegaonkar, S.M.
Khakal, V.R.
Joshi, A.A.
Nargund, S.L.
Shinde, S.D.
Khan, N.S.
author_facet Gunjegaonkar, S.M.
Khakal, V.R.
Joshi, A.A.
Nargund, S.L.
Shinde, S.D.
Khan, N.S.
author_sort Gunjegaonkar, S.M.
collection PubMed
description BACKGROUND: Ayurdvedic derived medicines are most promising and effective in the treatment of several cardiovascular diseases. Cocculus hirsutus (CH) has been reported for broad spectrum of activities like anticancer, antidiabetic, antioxidant, cardiotonic and hypotensive etc. OBJECTIVES: The present study aimed to find the cardio-protective effect of CH in experimental hypertension in rats. MATERIALS AND METHODS: For acute renal hypertension, CH animals were pre-treated with CH-1 (250 mg/kg) and CH-2 (500 mg/kg) p. o. for 14 days. On the 15th day, hypertension was induced by renal occlusion and the mean arterial blood pressure (MABP) was recorded. For CAL pretreatment of CH-1 and CH-2 was given for 7 days on the 8th day animals were operated on for ligation. The MABP and the time of onset of ventricular tachycardia (VT), premature ventricular systole (PVS) were recorded. For induction of hypercholesterolemia, animals were fed with a high cholesterol diet (CD) with CH-1 and CH-2 for 21 days. The antioxidant potential of CH was done using the assay of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GPx). RESULTS: CH treatment significantly decreases the MABP, the onset of VT and PVS. The histology show intact cardiac muscle with minimum necrosis and inflammation. CH treatment shows significant decrease in cholesterol, triglycerides, and glucose while HDL levels are significantly increased. The aortic section of CH-treated animals shows the intact layers of the artery, normal thickness and restoration of antioxidant enzymatic activity. CONCLUSION: The study shows significant cardio protective effect of CH in experimental animals.
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spelling pubmed-96787792022-11-23 Cardio-protective effect of Cocculus hirsutus in experimental hypertension in rats Gunjegaonkar, S.M. Khakal, V.R. Joshi, A.A. Nargund, S.L. Shinde, S.D. Khan, N.S. J Ayurveda Integr Med Original Research Article BACKGROUND: Ayurdvedic derived medicines are most promising and effective in the treatment of several cardiovascular diseases. Cocculus hirsutus (CH) has been reported for broad spectrum of activities like anticancer, antidiabetic, antioxidant, cardiotonic and hypotensive etc. OBJECTIVES: The present study aimed to find the cardio-protective effect of CH in experimental hypertension in rats. MATERIALS AND METHODS: For acute renal hypertension, CH animals were pre-treated with CH-1 (250 mg/kg) and CH-2 (500 mg/kg) p. o. for 14 days. On the 15th day, hypertension was induced by renal occlusion and the mean arterial blood pressure (MABP) was recorded. For CAL pretreatment of CH-1 and CH-2 was given for 7 days on the 8th day animals were operated on for ligation. The MABP and the time of onset of ventricular tachycardia (VT), premature ventricular systole (PVS) were recorded. For induction of hypercholesterolemia, animals were fed with a high cholesterol diet (CD) with CH-1 and CH-2 for 21 days. The antioxidant potential of CH was done using the assay of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GPx). RESULTS: CH treatment significantly decreases the MABP, the onset of VT and PVS. The histology show intact cardiac muscle with minimum necrosis and inflammation. CH treatment shows significant decrease in cholesterol, triglycerides, and glucose while HDL levels are significantly increased. The aortic section of CH-treated animals shows the intact layers of the artery, normal thickness and restoration of antioxidant enzymatic activity. CONCLUSION: The study shows significant cardio protective effect of CH in experimental animals. Elsevier 2022 2022-11-17 /pmc/articles/PMC9678779/ /pubmed/36403501 http://dx.doi.org/10.1016/j.jaim.2022.100652 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research Article
Gunjegaonkar, S.M.
Khakal, V.R.
Joshi, A.A.
Nargund, S.L.
Shinde, S.D.
Khan, N.S.
Cardio-protective effect of Cocculus hirsutus in experimental hypertension in rats
title Cardio-protective effect of Cocculus hirsutus in experimental hypertension in rats
title_full Cardio-protective effect of Cocculus hirsutus in experimental hypertension in rats
title_fullStr Cardio-protective effect of Cocculus hirsutus in experimental hypertension in rats
title_full_unstemmed Cardio-protective effect of Cocculus hirsutus in experimental hypertension in rats
title_short Cardio-protective effect of Cocculus hirsutus in experimental hypertension in rats
title_sort cardio-protective effect of cocculus hirsutus in experimental hypertension in rats
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678779/
https://www.ncbi.nlm.nih.gov/pubmed/36403501
http://dx.doi.org/10.1016/j.jaim.2022.100652
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