A bovine antibody possessing an ultralong complementarity-determining region CDRH3 targets a highly conserved epitope in sarbecovirus spike proteins

Broadly neutralizing antibodies have huge potential as novel antiviral therapeutics due to their ability to recognize highly conserved epitopes that are seldom mutated in viral variants. A subset of bovine antibodies possess an ultralong complementarity-determining region (CDR)H3 that is highly adep...

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Detalles Bibliográficos
Autores principales: Burke, Matthew J., Scott, James N.F., Minshull, Thomas C., Gao, Zeqian, Manfield, Iain, Savic, Sinisa, Stockley, Peter G., Calabrese, Antonio N., Boyes, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678781/
https://www.ncbi.nlm.nih.gov/pubmed/36272646
http://dx.doi.org/10.1016/j.jbc.2022.102624

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678781/
https://www.ncbi.nlm.nih.gov/pubmed/36272646
http://dx.doi.org/10.1016/j.jbc.2022.102624

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