Cargando…

STNM01, the RNA oligonucleotide targeting carbohydrate sulfotransferase 15, as second-line therapy for chemotherapy-refractory patients with unresectable pancreatic cancer: An open label, phase I/IIa trial

BACKGROUND: The impact of stroma-targeting therapy on tumor immune suppression is largely unexplored. An RNA oligonucleotide, STNM01, has been shown to repress carbohydrate sulfotransferase 15 (CHST15) responsible for tumor proteoglycan synthesis and matrix remodeling. This phase I/IIa study aimed t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fujisawa, Toshio, Tsuchiya, Takayoshi, Kato, Motohiko, Mizuide, Masafumi, Takakura, Kazuki, Nishimura, Makoto, Kutsumi, Hiromu, Matsuda, Yoko, Arai, Tomio, Ryozawa, Shomei, Itoi, Takao, Isayama, Hiroyuki, Saya, Hideyuki, Yahagi, Naohisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678806/ https://www.ncbi.nlm.nih.gov/pubmed/36425867 http://dx.doi.org/10.1016/j.eclinm.2022.101731

Ejemplares similares

Modified double-guidewire technique using a unique double-lumen sphincterotome for difficult biliary cannulation
por: Shiomi, Hideyuki, et al.
Publicado: (2020)

Choledocho-duodenal Fistula Formation Caused by the Progression of Pancreatic Cancer
por: Tanisaka, Yuki, et al.
Publicado: (2020)

The Clinical Potential of Oligonucleotide Therapeutics against Pancreatic Cancer
por: Takakura, Kazuki, et al.
Publicado: (2019)

A Prospective Multicenter Randomized Feasibility Trial of Double-guidewire Techniques for Difficult Biliary Cannulation Comparing a New Double-guidewire-supported Sphincterotome (MagicTome) to a Conventional Device
por: Ogawa, Tomoya, et al.
Publicado: (2021)

Endoscopic closure assisted by a novel traction device after duodenal endoscopic submucosal dissection
por: Tashima, Tomoaki, et al.
Publicado: (2020)

Novel technique using pancreatic duct stent facilitates difficult biliary cannulation in patients with Roux‐en‐Y anatomy (with video)
por: Tanisaka, Yuki, et al.
Publicado: (2019)

Successful endoscopic retrograde cholangiopancreatography using pancreatic guidewire placement for biliary cannulation in a patient with situs inversus and Billroth‐I gastrectomy (with video)
por: Tanisaka, Yuki, et al.
Publicado: (2019)

Texture and color enhancement imaging facilitates the identification of pancreatic and bile duct orifices after endoscopic papillectomy
por: Tanisaka, Yuki, et al.
Publicado: (2022)

Usefulness of texture and color enhancement imaging in peroral cholangioscopy
por: Tanisaka, Yuki, et al.
Publicado: (2022)

Use of texture and color enhancement imaging to identify the pancreatic duct orifice in a patient with a pancreaticojejunal anastomotic stricture
por: Tanisaka, Yuki, et al.
Publicado: (2022)

A novel sphincterotome facilitates endoscopic sphincterotomy in patients with Roux-en-Y gastrectomy
por: Tanisaka, Yuki, et al.
Publicado: (2022)

Usefulness of a novel sphincterotome for transpancreatic biliary sphincterotomy to achieve selective biliary cannulation in patients with Roux-en-Y gastrectomy
por: Tanisaka, Yuki, et al.
Publicado: (2023)

Single-balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography in patients with surgically altered anatomy: a technical review
por: Tanisaka, Yuki, et al.
Publicado: (2023)

Do we need to take care of nodular scar following gastric ESD?
por: Kato, Motohiko, et al.
Publicado: (2018)

Suturing the mucosal defect after ESD
por: Kato, Motohiko, et al.
Publicado: (2020)

Current Status of Needles in the Optimization of Endoscopic Ultrasound-Guided Procedures
por: Fujita, Akashi, et al.
Publicado: (2020)

Complications of Endoscopic Ultrasound-Guided Fine Needle Aspiration: A Narrative Review
por: Mizuide, Masafumi, et al.
Publicado: (2020)

Usefulness of texture- and color-enhancement imaging for identifying the bleeding point in a patient with post–endoscopic sphincterotomy bleeding
por: Tanisaka, Yuki, et al.
Publicado: (2023)

Water pressure method overcomes the gravitational side in endoscopic submucosal dissection for gastric cancer
por: Masunaga, Teppei, et al.
Publicado: (2021)

Endoscopic resection of superficial non‐ampullary duodenal epithelial tumor
por: Kato, Motohiko, et al.
Publicado: (2021)

Endoscopic closure, involving the muscle layer, of a duodenal post-resection mucosal defect using double-layer suturing assisted by reopenable clips
por: Masunaga, Teppei, et al.
Publicado: (2022)

Novel therapeutic thin endoscope facilitates endoscopic submucosal dissection for cervical esophageal cancer involving the pharyngoesophageal junction
por: Masunaga, Teppei, et al.
Publicado: (2023)

Biliary Cannulation in Patients with Roux-en-Y Gastrectomy: An Analysis of the Factors Associated with Successful Cannulation
por: Tanisaka, Yuki, et al.
Publicado: (2020)

Diagnosis of Biliary Strictures Using Probe-Based Confocal Laser Endomicroscopy under the Direct View of Peroral Cholangioscopy: Results of a Prospective Study (with Video)
por: Tanisaka, Yuki, et al.
Publicado: (2020)

Endoscopic hemostasis using gel immersion endoscopy for duodenal ulcer and a sigmoid colon polyp: A novel gel injection method
por: Jinushi, Ryuhei, et al.
Publicado: (2022)

A novel triangle traction method using a clip-band traction device for endoscopic submucosal dissection of early gastric cancer involving the pyloric ring
por: Muramatsu, Takahiro, et al.
Publicado: (2022)

Successful endoscopic submucosal dissection for early gastric cancer involving the pyloric ring using a combination of water and gel immersion with the tunneling method
por: Muramatsu, Takahiro, et al.
Publicado: (2023)

Usefulness of the “newly designed” short-type single-balloon enteroscope for ERCP in patients with Roux-en-Y gastrectomy: a pilot study
por: Tanisaka, Yuki, et al.
Publicado: (2018)

Does endoscopic ultrasound-guided fine needle biopsy using a Franseen needle really offer high diagnostic accuracy? A propensity-matched analysis
por: Fujita, Akashi, et al.
Publicado: (2019)

Endoscopic resection using an over-the-scope clip for duodenal neuroendocrine tumors
por: Tashima, Tomoaki, et al.
Publicado: (2021)

A successful case of endoscopic submucosal dissection using the water pressure method for early gastric cancer with severe fibrosis
por: Miyazaki, Kurato, et al.
Publicado: (2022)

Esophageal endoscopic submucosal dissection using a novel thin therapeutic scope for early esophageal cancer adjacent to chemoradiotherapy-induced stricture
por: Miyazaki, Kurato, et al.
Publicado: (2023)

Diagnostic Process Using Endoscopy for Biliary Strictures: A Narrative Review
por: Tanisaka, Yuki, et al.
Publicado: (2021)

Recent Advances of Interventional Endoscopic Retrograde Cholangiopancreatography and Endoscopic Ultrasound for Patients with Surgically Altered Anatomy
por: Tanisaka, Yuki, et al.
Publicado: (2021)

Adrenocortical Carcinoma Diagnosed by Endoscopic Ultrasound-guided Fine-needle Aspiration
por: Katsuda, Hiromune, et al.
Publicado: (2021)

Prognostic impact of carbohydrate sulfotransferase 15 in patients with pancreatic ductal adenocarcinoma
por: Ito, Zensho, et al.
Publicado: (2017)

How to differentiate between invasive lobular carcinoma metastasis and type 4 advanced gastric cancer: The importance of immunohistochemistry
por: Jinushi, Ryuhei, et al.
Publicado: (2023)

Overexpression of carbohydrate sulfotransferase 15 in pancreatic cancer stroma is associated with worse prognosis
por: Matsuda, Yoko, et al.
Publicado: (2019)

Esophageal endoscopic submucosal dissection on postendoscopic variceal ligation scars with injection under red dichromatic imaging
por: Miyazaki, Kurato, et al.
Publicado: (2021)

Pathogenesis and management of gastrointestinal inflammation and fibrosis: from inflammatory bowel diseases to endoscopic surgery
por: Iwata, Kentaro, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9rb7j5e98odmsfmiro1v2uj1qh