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Triglyceride-glucose index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney disease
Triglyceride–glucose (TyG) index has been proposed to be a simple, economical, and reliable marker of insulin resistance. We aimed to investigate whether TyG is an independent predictor of hyperuricemia in diabetic kidney disease (DKD) populations by conducting a cross-sectional and longitudinal stu...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678876/ https://www.ncbi.nlm.nih.gov/pubmed/36411302 http://dx.doi.org/10.1038/s41598-022-23478-1 |
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author | Li, Qiuhong Shao, Xian Zhou, Saijun Cui, Zhuang Liu, Hongyan Wang, Tongdan Fan, Xiaoguang Yu, Pei |
author_facet | Li, Qiuhong Shao, Xian Zhou, Saijun Cui, Zhuang Liu, Hongyan Wang, Tongdan Fan, Xiaoguang Yu, Pei |
author_sort | Li, Qiuhong |
collection | PubMed |
description | Triglyceride–glucose (TyG) index has been proposed to be a simple, economical, and reliable marker of insulin resistance. We aimed to investigate whether TyG is an independent predictor of hyperuricemia in diabetic kidney disease (DKD) populations by conducting a cross-sectional and longitudinal study. A total of 6,471 patients were enrolled in cross-sectional analysis, and 3,634 patients without hyperuricemia at the baseline were included in longitudinal analysis and were followed up for a median of 23.0 months. Hyperuricemia was categorized as a serum uric acid level ≥ 420 umol/L (7 mg/dL). In this study, 19.58% of participants had hyperuricemia. In the cross-sectional analysis, multivariate logistics regression analysis showed that the ORs (95% CI) for hyperuricemia in the second, third, and fourth TyG quartiles were 1.40 (95% CI 0.73–2.65), 1.69 (95% CI 0.90–3.18), and 4.53 (95% CI 2.39–8.57), respectively, compared with the first quartile. Longitudinally, the Kaplan–Meier survival analysis showed that higher TyG levels predicted higher incidence of hyperuricemia. Multivariate Cox regression model revealed that the hazard ratios for hyperuricemia in the upper quartiles of the TyG index were 1.69 (95% CI 0.97–2.93), 2.23 (95% CI 1.33–3.75), and 2.50 (95% CI 1.46–4.27), respectively, compared with the first quartile. Moreover, the subgroup analyses revealed that the relationship between TyG levels and hyperuricemia was robust in DKD patients. Our findings indicate a significant independent correlation between the TyG index and the risk of hyperuricemia in DKD patients. |
format | Online Article Text |
id | pubmed-9678876 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-96788762022-11-23 Triglyceride-glucose index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney disease Li, Qiuhong Shao, Xian Zhou, Saijun Cui, Zhuang Liu, Hongyan Wang, Tongdan Fan, Xiaoguang Yu, Pei Sci Rep Article Triglyceride–glucose (TyG) index has been proposed to be a simple, economical, and reliable marker of insulin resistance. We aimed to investigate whether TyG is an independent predictor of hyperuricemia in diabetic kidney disease (DKD) populations by conducting a cross-sectional and longitudinal study. A total of 6,471 patients were enrolled in cross-sectional analysis, and 3,634 patients without hyperuricemia at the baseline were included in longitudinal analysis and were followed up for a median of 23.0 months. Hyperuricemia was categorized as a serum uric acid level ≥ 420 umol/L (7 mg/dL). In this study, 19.58% of participants had hyperuricemia. In the cross-sectional analysis, multivariate logistics regression analysis showed that the ORs (95% CI) for hyperuricemia in the second, third, and fourth TyG quartiles were 1.40 (95% CI 0.73–2.65), 1.69 (95% CI 0.90–3.18), and 4.53 (95% CI 2.39–8.57), respectively, compared with the first quartile. Longitudinally, the Kaplan–Meier survival analysis showed that higher TyG levels predicted higher incidence of hyperuricemia. Multivariate Cox regression model revealed that the hazard ratios for hyperuricemia in the upper quartiles of the TyG index were 1.69 (95% CI 0.97–2.93), 2.23 (95% CI 1.33–3.75), and 2.50 (95% CI 1.46–4.27), respectively, compared with the first quartile. Moreover, the subgroup analyses revealed that the relationship between TyG levels and hyperuricemia was robust in DKD patients. Our findings indicate a significant independent correlation between the TyG index and the risk of hyperuricemia in DKD patients. Nature Publishing Group UK 2022-11-21 /pmc/articles/PMC9678876/ /pubmed/36411302 http://dx.doi.org/10.1038/s41598-022-23478-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Li, Qiuhong Shao, Xian Zhou, Saijun Cui, Zhuang Liu, Hongyan Wang, Tongdan Fan, Xiaoguang Yu, Pei Triglyceride-glucose index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney disease |
title | Triglyceride-glucose index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney disease |
title_full | Triglyceride-glucose index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney disease |
title_fullStr | Triglyceride-glucose index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney disease |
title_full_unstemmed | Triglyceride-glucose index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney disease |
title_short | Triglyceride-glucose index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney disease |
title_sort | triglyceride-glucose index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678876/ https://www.ncbi.nlm.nih.gov/pubmed/36411302 http://dx.doi.org/10.1038/s41598-022-23478-1 |
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