Regulome analysis in B-acute lymphoblastic leukemia exposes Core Binding Factor addiction as a therapeutic vulnerability

The ETV6-RUNX1 onco-fusion arises in utero, initiating a clinically silent pre-leukemic state associated with the development of pediatric B-acute lymphoblastic leukemia (B-ALL). We characterize the ETV6-RUNX1 regulome by integrating chromatin immunoprecipitation- and RNA-sequencing and show that ET...

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Detalles Bibliográficos
Autores principales: Wray, Jason P., Deltcheva, Elitza M., Boiers, Charlotta, Richardson, Simon Е, Chhetri, Jyoti Bikram, Brown, John, Gagrica, Sladjana, Guo, Yanping, Illendula, Anuradha, Martens, Joost H. A., Stunnenberg, Hendrik G., Bushweller, John H., Nimmo, Rachael, Enver, Tariq
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678885/
https://www.ncbi.nlm.nih.gov/pubmed/36411286
http://dx.doi.org/10.1038/s41467-022-34653-3

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