Cargando…
G protein gamma subunit, a hidden master regulator of GPCR signaling
Heterotrimeric G proteins (αβγ subunits) that are activated by G protein-coupled receptors (GPCRs) mediate the biological responses of eukaryotic cells to extracellular signals. The α subunits and the tightly bound βγ subunit complex of G proteins have been extensively studied and shown to control t...
Autores principales: | Kankanamge, Dinesh, Tennakoon, Mithila, Karunarathne, Ajith, Gautam, N. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678972/ https://www.ncbi.nlm.nih.gov/pubmed/36272647 http://dx.doi.org/10.1016/j.jbc.2022.102618 |
Ejemplares similares
-
The spatial distribution of GPCR and Gβγ activity across a cell dictates PIP3 dynamics
por: Wijayaratna, Dhanushan, et al.
Publicado: (2023) -
A short C-terminal peptide in Gγ regulates Gβγ signaling efficacy
por: Tennakoon, Mithila, et al.
Publicado: (2021) -
CaaX-motif-adjacent residues influence G protein gamma (Gγ) prenylation under suboptimal conditions
por: Tennakoon, Mithila, et al.
Publicado: (2023) -
G protein–coupled receptor interactions with arrestins and GPCR kinases: The unresolved issue of signal bias
por: Chen, Qiuyan, et al.
Publicado: (2022) -
Dissociation of the G protein βγ from the Gq–PLCβ complex partially attenuates PIP2 hydrolysis
por: Kankanamge, Dinesh, et al.
Publicado: (2021)