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Mesenchymal stem cell therapy for ischemic stroke: Novel insight into the crosstalk with immune cells
Stroke, a cerebrovascular accident, is prevalent and the second highest cause of death globally across patient populations; it is as a significant cause of morbidity and mortality. Mesenchymal stem cell (MSC) transplantation is emerging as a promising treatment for alleviating neurological deficits,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679024/ https://www.ncbi.nlm.nih.gov/pubmed/36425795 http://dx.doi.org/10.3389/fneur.2022.1048113 |
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author | Tan, Nana Xin, Wenqiang Huang, Min Mao, Yuling |
author_facet | Tan, Nana Xin, Wenqiang Huang, Min Mao, Yuling |
author_sort | Tan, Nana |
collection | PubMed |
description | Stroke, a cerebrovascular accident, is prevalent and the second highest cause of death globally across patient populations; it is as a significant cause of morbidity and mortality. Mesenchymal stem cell (MSC) transplantation is emerging as a promising treatment for alleviating neurological deficits, as indicated by a great number of animal and clinical studies. The potential of regulating the immune system is currently being explored as a therapeutic target after ischemic stroke. This study will discuss recent evidence that MSCs can harness the immune system by interacting with immune cells to boost neurologic recovery effectively. Moreover, a notion will be given to MSCs participating in multiple pathological processes, such as increasing cell survival angiogenesis and suppressing cell apoptosis and autophagy in several phases of ischemic stroke, consequently promoting neurological function recovery. We will conclude the review by highlighting the clinical opportunities for MSCs by reviewing the safety, feasibility, and efficacy of MSCs therapy. |
format | Online Article Text |
id | pubmed-9679024 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96790242022-11-23 Mesenchymal stem cell therapy for ischemic stroke: Novel insight into the crosstalk with immune cells Tan, Nana Xin, Wenqiang Huang, Min Mao, Yuling Front Neurol Neurology Stroke, a cerebrovascular accident, is prevalent and the second highest cause of death globally across patient populations; it is as a significant cause of morbidity and mortality. Mesenchymal stem cell (MSC) transplantation is emerging as a promising treatment for alleviating neurological deficits, as indicated by a great number of animal and clinical studies. The potential of regulating the immune system is currently being explored as a therapeutic target after ischemic stroke. This study will discuss recent evidence that MSCs can harness the immune system by interacting with immune cells to boost neurologic recovery effectively. Moreover, a notion will be given to MSCs participating in multiple pathological processes, such as increasing cell survival angiogenesis and suppressing cell apoptosis and autophagy in several phases of ischemic stroke, consequently promoting neurological function recovery. We will conclude the review by highlighting the clinical opportunities for MSCs by reviewing the safety, feasibility, and efficacy of MSCs therapy. Frontiers Media S.A. 2022-11-08 /pmc/articles/PMC9679024/ /pubmed/36425795 http://dx.doi.org/10.3389/fneur.2022.1048113 Text en Copyright © 2022 Tan, Xin, Huang and Mao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Tan, Nana Xin, Wenqiang Huang, Min Mao, Yuling Mesenchymal stem cell therapy for ischemic stroke: Novel insight into the crosstalk with immune cells |
title | Mesenchymal stem cell therapy for ischemic stroke: Novel insight into the crosstalk with immune cells |
title_full | Mesenchymal stem cell therapy for ischemic stroke: Novel insight into the crosstalk with immune cells |
title_fullStr | Mesenchymal stem cell therapy for ischemic stroke: Novel insight into the crosstalk with immune cells |
title_full_unstemmed | Mesenchymal stem cell therapy for ischemic stroke: Novel insight into the crosstalk with immune cells |
title_short | Mesenchymal stem cell therapy for ischemic stroke: Novel insight into the crosstalk with immune cells |
title_sort | mesenchymal stem cell therapy for ischemic stroke: novel insight into the crosstalk with immune cells |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679024/ https://www.ncbi.nlm.nih.gov/pubmed/36425795 http://dx.doi.org/10.3389/fneur.2022.1048113 |
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