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Comparative study of the evolution of cancer gene duplications across fish
Comparative studies of cancer‐related genes not only provide novel information about their evolution and function but also an understanding of cancer as a driving force in biological systems and species’ life histories. So far, these studies have focused on mammals. Here, we provide the first compar...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679246/ https://www.ncbi.nlm.nih.gov/pubmed/36426117 http://dx.doi.org/10.1111/eva.13481 |
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author | Baines, Ciara Meitern, Richard Kreitsberg, Randel Sepp, Tuul |
author_facet | Baines, Ciara Meitern, Richard Kreitsberg, Randel Sepp, Tuul |
author_sort | Baines, Ciara |
collection | PubMed |
description | Comparative studies of cancer‐related genes not only provide novel information about their evolution and function but also an understanding of cancer as a driving force in biological systems and species’ life histories. So far, these studies have focused on mammals. Here, we provide the first comparative study of cancer‐related gene copy number variation in fish. Fishes are a paraphyletic group whose last common ancestor is also an ancestor of the tetrapods, and accordingly, their tumour suppression mechanisms should include most of the mammalian mechanisms and also reveal novel (but potentially phylogenetically older) previously undetected mechanisms. We have matched the sequenced genomes of 65 fish species from the Ensemble database with the cancer gene information from the COSMIC database. By calculating the number of gene copies across species using the Ensembl CAFE data (providing species trees for gene copy number counts), we used a less resource‐demanding method for homolog identification. Our analysis demonstrates a masked relationship between cancer‐related gene copy number variation (CNV) and maximum lifespan in fish species, suggesting that a higher number of copies of tumour suppressor genes lengthens and the number of copies of oncogenes shortens lifespan. Based on the positive correlation between the number of copies of tumour suppressors and oncogenes, we show which species have more tumour suppressors in relation to oncogenes. It could be suggested that these species have stronger genetic defences against oncogenic processes. Fish studies could be a largely unexplored treasure trove for understanding the evolution and ecology of cancer, providing novel insights into the study of cancer and tumour suppression, in addition to fish evolution, life‐history trade‐offs, and ecology. |
format | Online Article Text |
id | pubmed-9679246 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96792462022-11-23 Comparative study of the evolution of cancer gene duplications across fish Baines, Ciara Meitern, Richard Kreitsberg, Randel Sepp, Tuul Evol Appl Original Articles Comparative studies of cancer‐related genes not only provide novel information about their evolution and function but also an understanding of cancer as a driving force in biological systems and species’ life histories. So far, these studies have focused on mammals. Here, we provide the first comparative study of cancer‐related gene copy number variation in fish. Fishes are a paraphyletic group whose last common ancestor is also an ancestor of the tetrapods, and accordingly, their tumour suppression mechanisms should include most of the mammalian mechanisms and also reveal novel (but potentially phylogenetically older) previously undetected mechanisms. We have matched the sequenced genomes of 65 fish species from the Ensemble database with the cancer gene information from the COSMIC database. By calculating the number of gene copies across species using the Ensembl CAFE data (providing species trees for gene copy number counts), we used a less resource‐demanding method for homolog identification. Our analysis demonstrates a masked relationship between cancer‐related gene copy number variation (CNV) and maximum lifespan in fish species, suggesting that a higher number of copies of tumour suppressor genes lengthens and the number of copies of oncogenes shortens lifespan. Based on the positive correlation between the number of copies of tumour suppressors and oncogenes, we show which species have more tumour suppressors in relation to oncogenes. It could be suggested that these species have stronger genetic defences against oncogenic processes. Fish studies could be a largely unexplored treasure trove for understanding the evolution and ecology of cancer, providing novel insights into the study of cancer and tumour suppression, in addition to fish evolution, life‐history trade‐offs, and ecology. John Wiley and Sons Inc. 2022-09-29 /pmc/articles/PMC9679246/ /pubmed/36426117 http://dx.doi.org/10.1111/eva.13481 Text en © 2022 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Baines, Ciara Meitern, Richard Kreitsberg, Randel Sepp, Tuul Comparative study of the evolution of cancer gene duplications across fish |
title | Comparative study of the evolution of cancer gene duplications across fish |
title_full | Comparative study of the evolution of cancer gene duplications across fish |
title_fullStr | Comparative study of the evolution of cancer gene duplications across fish |
title_full_unstemmed | Comparative study of the evolution of cancer gene duplications across fish |
title_short | Comparative study of the evolution of cancer gene duplications across fish |
title_sort | comparative study of the evolution of cancer gene duplications across fish |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679246/ https://www.ncbi.nlm.nih.gov/pubmed/36426117 http://dx.doi.org/10.1111/eva.13481 |
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