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Ceritinib (LDK378) prevents bone loss via suppressing Akt and NF-κB-induced osteoclast formation

BACKGROUND: Ceritinib is used for the treatment of patients with anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC), who are at the risk of developing bone metastasis. During bone metastasis, tumor cells release factors that induce osteoclast formation, resulting in osteo...

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Detalles Bibliográficos
Autores principales:	He, Wenxin, Cao, Xiankun, Kong, Keyu, Rong, Kewei, Han, Shuai, Qin, An
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679281/ https://www.ncbi.nlm.nih.gov/pubmed/36425467 http://dx.doi.org/10.3389/fendo.2022.939959

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