The emerging roles and therapeutic potential of B cells in sepsis

Sepsis is a life-threatening syndrome caused by anomalous host response to infection. The pathogenesis of sepsis is complex, and immune dysfunction is the central link in its occurrence and development. The sepsis immune response is not a local and transient process but a complex and continuous proc...

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Autores principales: Ma, Chengyong, Liu, Hanrui, Yang, Shuo, Li, Hong, Liao, Xuelian, Kang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679374/
https://www.ncbi.nlm.nih.gov/pubmed/36425582
http://dx.doi.org/10.3389/fphar.2022.1034667
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author Ma, Chengyong
Liu, Hanrui
Yang, Shuo
Li, Hong
Liao, Xuelian
Kang, Yan
author_facet Ma, Chengyong
Liu, Hanrui
Yang, Shuo
Li, Hong
Liao, Xuelian
Kang, Yan
author_sort Ma, Chengyong
collection PubMed
description Sepsis is a life-threatening syndrome caused by anomalous host response to infection. The pathogenesis of sepsis is complex, and immune dysfunction is the central link in its occurrence and development. The sepsis immune response is not a local and transient process but a complex and continuous process involving all major cell types of innate and adaptive immunity. B cells are traditionally studied for their ability to produce antibodies in the context of mediating humoral immunity. However, over the past few years, B cells have been increasingly recognized as key modulators of adaptive and innate immunity, and they can participate in immune responses by presenting antigens, producing cytokines, and modulating other immune cells. Recently, increasing evidence links B-cell dysfunction to mechanisms of immune derangement in sepsis, which has drawn attention to the powerful properties of this unique immune cell type in sepsis. Here, we reviewed the dynamic alterations of B cells and their novel roles in animal models and patients with sepsis, and provided new perspectives for therapeutic strategies targeting B cells in sepsis.
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spelling pubmed-96793742022-11-23 The emerging roles and therapeutic potential of B cells in sepsis Ma, Chengyong Liu, Hanrui Yang, Shuo Li, Hong Liao, Xuelian Kang, Yan Front Pharmacol Pharmacology Sepsis is a life-threatening syndrome caused by anomalous host response to infection. The pathogenesis of sepsis is complex, and immune dysfunction is the central link in its occurrence and development. The sepsis immune response is not a local and transient process but a complex and continuous process involving all major cell types of innate and adaptive immunity. B cells are traditionally studied for their ability to produce antibodies in the context of mediating humoral immunity. However, over the past few years, B cells have been increasingly recognized as key modulators of adaptive and innate immunity, and they can participate in immune responses by presenting antigens, producing cytokines, and modulating other immune cells. Recently, increasing evidence links B-cell dysfunction to mechanisms of immune derangement in sepsis, which has drawn attention to the powerful properties of this unique immune cell type in sepsis. Here, we reviewed the dynamic alterations of B cells and their novel roles in animal models and patients with sepsis, and provided new perspectives for therapeutic strategies targeting B cells in sepsis. Frontiers Media S.A. 2022-11-08 /pmc/articles/PMC9679374/ /pubmed/36425582 http://dx.doi.org/10.3389/fphar.2022.1034667 Text en Copyright © 2022 Ma, Liu, Yang, Li, Liao and Kang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Ma, Chengyong
Liu, Hanrui
Yang, Shuo
Li, Hong
Liao, Xuelian
Kang, Yan
The emerging roles and therapeutic potential of B cells in sepsis
title The emerging roles and therapeutic potential of B cells in sepsis
title_full The emerging roles and therapeutic potential of B cells in sepsis
title_fullStr The emerging roles and therapeutic potential of B cells in sepsis
title_full_unstemmed The emerging roles and therapeutic potential of B cells in sepsis
title_short The emerging roles and therapeutic potential of B cells in sepsis
title_sort emerging roles and therapeutic potential of b cells in sepsis
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679374/
https://www.ncbi.nlm.nih.gov/pubmed/36425582
http://dx.doi.org/10.3389/fphar.2022.1034667
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