The emerging roles and therapeutic potential of B cells in sepsis
Sepsis is a life-threatening syndrome caused by anomalous host response to infection. The pathogenesis of sepsis is complex, and immune dysfunction is the central link in its occurrence and development. The sepsis immune response is not a local and transient process but a complex and continuous proc...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679374/ https://www.ncbi.nlm.nih.gov/pubmed/36425582 http://dx.doi.org/10.3389/fphar.2022.1034667 |
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author | Ma, Chengyong Liu, Hanrui Yang, Shuo Li, Hong Liao, Xuelian Kang, Yan |
author_facet | Ma, Chengyong Liu, Hanrui Yang, Shuo Li, Hong Liao, Xuelian Kang, Yan |
author_sort | Ma, Chengyong |
collection | PubMed |
description | Sepsis is a life-threatening syndrome caused by anomalous host response to infection. The pathogenesis of sepsis is complex, and immune dysfunction is the central link in its occurrence and development. The sepsis immune response is not a local and transient process but a complex and continuous process involving all major cell types of innate and adaptive immunity. B cells are traditionally studied for their ability to produce antibodies in the context of mediating humoral immunity. However, over the past few years, B cells have been increasingly recognized as key modulators of adaptive and innate immunity, and they can participate in immune responses by presenting antigens, producing cytokines, and modulating other immune cells. Recently, increasing evidence links B-cell dysfunction to mechanisms of immune derangement in sepsis, which has drawn attention to the powerful properties of this unique immune cell type in sepsis. Here, we reviewed the dynamic alterations of B cells and their novel roles in animal models and patients with sepsis, and provided new perspectives for therapeutic strategies targeting B cells in sepsis. |
format | Online Article Text |
id | pubmed-9679374 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96793742022-11-23 The emerging roles and therapeutic potential of B cells in sepsis Ma, Chengyong Liu, Hanrui Yang, Shuo Li, Hong Liao, Xuelian Kang, Yan Front Pharmacol Pharmacology Sepsis is a life-threatening syndrome caused by anomalous host response to infection. The pathogenesis of sepsis is complex, and immune dysfunction is the central link in its occurrence and development. The sepsis immune response is not a local and transient process but a complex and continuous process involving all major cell types of innate and adaptive immunity. B cells are traditionally studied for their ability to produce antibodies in the context of mediating humoral immunity. However, over the past few years, B cells have been increasingly recognized as key modulators of adaptive and innate immunity, and they can participate in immune responses by presenting antigens, producing cytokines, and modulating other immune cells. Recently, increasing evidence links B-cell dysfunction to mechanisms of immune derangement in sepsis, which has drawn attention to the powerful properties of this unique immune cell type in sepsis. Here, we reviewed the dynamic alterations of B cells and their novel roles in animal models and patients with sepsis, and provided new perspectives for therapeutic strategies targeting B cells in sepsis. Frontiers Media S.A. 2022-11-08 /pmc/articles/PMC9679374/ /pubmed/36425582 http://dx.doi.org/10.3389/fphar.2022.1034667 Text en Copyright © 2022 Ma, Liu, Yang, Li, Liao and Kang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Ma, Chengyong Liu, Hanrui Yang, Shuo Li, Hong Liao, Xuelian Kang, Yan The emerging roles and therapeutic potential of B cells in sepsis |
title | The emerging roles and therapeutic potential of B cells in sepsis |
title_full | The emerging roles and therapeutic potential of B cells in sepsis |
title_fullStr | The emerging roles and therapeutic potential of B cells in sepsis |
title_full_unstemmed | The emerging roles and therapeutic potential of B cells in sepsis |
title_short | The emerging roles and therapeutic potential of B cells in sepsis |
title_sort | emerging roles and therapeutic potential of b cells in sepsis |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679374/ https://www.ncbi.nlm.nih.gov/pubmed/36425582 http://dx.doi.org/10.3389/fphar.2022.1034667 |
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