The CARD8 T60 variant associates with NLRP1 and negatively regulates its activation

The NLRP1 inflammasome functions as canonical cytosolic sensor in response to intracellular infections and is implicated in auto-inflammatory diseases. But the regulation and signal transduction mechanisms of NLRP1 are incompletely understood. Here, we show that the T60 variant of CARD8, but not the...

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Detalles Bibliográficos
Autores principales: Xu, Zhihao, Deng, Shasha, Huang, Yuluo, Yang, Yunru, Sun, Liangqi, Liu, Hanyuan, Zhao, Dan, Zeng, Weihong, Yin, Xueying, Zheng, Peiyi, Wang, Yingying, Liu, Muziying, Zhao, Weidong, Xiao, Tsan Sam, Zhou, Ying, Jin, Tengchuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679424/
https://www.ncbi.nlm.nih.gov/pubmed/36426349
http://dx.doi.org/10.3389/fimmu.2022.1047922

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