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An Initial Study into the Role of Teriparatide in Absent or Delayed Regenerate Formation during Distraction Osteogenesis: A Case Series

PURPOSE: Distraction osteogenesis has been used for post-traumatic segmental bone defects. Absent or delayed callus formation in the distraction gap can lead to significant morbidity and affect the clinical outcome. Experimental evidence in animal models has demonstrated that teriparatide enhances t...

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Autores principales: Patil, Bharath, Kansay, Rajeev, Gupta, Sandeep, Kapoor, Anil, Sharma, Anmol, Mittal, Naveen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Jaypee Brothers Medical Publishers 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679595/
https://www.ncbi.nlm.nih.gov/pubmed/36466310
http://dx.doi.org/10.5005/jp-journals-10080-1464
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author Patil, Bharath
Kansay, Rajeev
Gupta, Sandeep
Kapoor, Anil
Sharma, Anmol
Mittal, Naveen
author_facet Patil, Bharath
Kansay, Rajeev
Gupta, Sandeep
Kapoor, Anil
Sharma, Anmol
Mittal, Naveen
author_sort Patil, Bharath
collection PubMed
description PURPOSE: Distraction osteogenesis has been used for post-traumatic segmental bone defects. Absent or delayed callus formation in the distraction gap can lead to significant morbidity and affect the clinical outcome. Experimental evidence in animal models has demonstrated that teriparatide enhances the consolidation of regenerate and also strengthens it. This study aimed to report our experience with recombinant teriparatide therapy for patients with regenerate insufficiency. MATERIALS AND METHODS: Nine out of 43 patients undergoing limb lengthening using the limb reconstruction system (LRS) fixator were diagnosed with regenerate insufficiency. With informed consent, these patients received a therapeutic regime of 20 μg of teriparatide administered subcutaneously once daily for a period of 3 months. RESULTS: The mean age in the sample was 40.22 years (SD 17.87). Regenerate insufficiency was diagnosed at a mean of 4.94 months (range 2.5–9 months) from surgery. Teriparatide injections were started at a mean of 6.94 months (range 4.5–11 months) from surgery. The sites of regenerate insufficiency were tibia (n = 5) and femur (n = 4). Favourable radiographic progress in visibility of callus was seen at a mean duration of 9.4 weeks (range 8–12 weeks) from the initiation of teriparatide therapy. No systemic complications were encountered. CONCLUSION: The initiation of teriparatide treatment as described in this study may be successful in triggering the osteogenic potential within poor regenerate and help in consolidation and avoid more invasive surgical procedures. HOW TO CITE THIS ARTICLE: Patil B, Kansay R, Gupta S, et al. An Initial Study into the Role of Teriparatide in Absent or Delayed Regenerate Formation during Distraction Osteogenesis: A Case Series. Strategies Trauma Limb Reconstr 2020;15(2):117–120.
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spelling pubmed-96795952022-12-02 An Initial Study into the Role of Teriparatide in Absent or Delayed Regenerate Formation during Distraction Osteogenesis: A Case Series Patil, Bharath Kansay, Rajeev Gupta, Sandeep Kapoor, Anil Sharma, Anmol Mittal, Naveen Strategies Trauma Limb Reconstr Original Article PURPOSE: Distraction osteogenesis has been used for post-traumatic segmental bone defects. Absent or delayed callus formation in the distraction gap can lead to significant morbidity and affect the clinical outcome. Experimental evidence in animal models has demonstrated that teriparatide enhances the consolidation of regenerate and also strengthens it. This study aimed to report our experience with recombinant teriparatide therapy for patients with regenerate insufficiency. MATERIALS AND METHODS: Nine out of 43 patients undergoing limb lengthening using the limb reconstruction system (LRS) fixator were diagnosed with regenerate insufficiency. With informed consent, these patients received a therapeutic regime of 20 μg of teriparatide administered subcutaneously once daily for a period of 3 months. RESULTS: The mean age in the sample was 40.22 years (SD 17.87). Regenerate insufficiency was diagnosed at a mean of 4.94 months (range 2.5–9 months) from surgery. Teriparatide injections were started at a mean of 6.94 months (range 4.5–11 months) from surgery. The sites of regenerate insufficiency were tibia (n = 5) and femur (n = 4). Favourable radiographic progress in visibility of callus was seen at a mean duration of 9.4 weeks (range 8–12 weeks) from the initiation of teriparatide therapy. No systemic complications were encountered. CONCLUSION: The initiation of teriparatide treatment as described in this study may be successful in triggering the osteogenic potential within poor regenerate and help in consolidation and avoid more invasive surgical procedures. HOW TO CITE THIS ARTICLE: Patil B, Kansay R, Gupta S, et al. An Initial Study into the Role of Teriparatide in Absent or Delayed Regenerate Formation during Distraction Osteogenesis: A Case Series. Strategies Trauma Limb Reconstr 2020;15(2):117–120. Jaypee Brothers Medical Publishers 2020 /pmc/articles/PMC9679595/ /pubmed/36466310 http://dx.doi.org/10.5005/jp-journals-10080-1464 Text en Copyright © 2020; The Author(s). https://creativecommons.org/licenses/by-nc-sa/4.0/© The Author(s). 2020 Open Access This article is distributed under the terms of the Creative Commons Attribution-Non Commercial-share alike license (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted distribution, and non-commercial reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. If you remix, transform, or build upon the material, you must distribute your contributions under the same license as original. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated.
spellingShingle Original Article
Patil, Bharath
Kansay, Rajeev
Gupta, Sandeep
Kapoor, Anil
Sharma, Anmol
Mittal, Naveen
An Initial Study into the Role of Teriparatide in Absent or Delayed Regenerate Formation during Distraction Osteogenesis: A Case Series
title An Initial Study into the Role of Teriparatide in Absent or Delayed Regenerate Formation during Distraction Osteogenesis: A Case Series
title_full An Initial Study into the Role of Teriparatide in Absent or Delayed Regenerate Formation during Distraction Osteogenesis: A Case Series
title_fullStr An Initial Study into the Role of Teriparatide in Absent or Delayed Regenerate Formation during Distraction Osteogenesis: A Case Series
title_full_unstemmed An Initial Study into the Role of Teriparatide in Absent or Delayed Regenerate Formation during Distraction Osteogenesis: A Case Series
title_short An Initial Study into the Role of Teriparatide in Absent or Delayed Regenerate Formation during Distraction Osteogenesis: A Case Series
title_sort initial study into the role of teriparatide in absent or delayed regenerate formation during distraction osteogenesis: a case series
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679595/
https://www.ncbi.nlm.nih.gov/pubmed/36466310
http://dx.doi.org/10.5005/jp-journals-10080-1464
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