ATM inhibition drives metabolic adaptation via induction of macropinocytosis

Macropinocytosis is a nonspecific endocytic process that may enhance cancer cell survival under nutrient-poor conditions. Ataxia-Telangiectasia mutated (ATM) is a tumor suppressor that has been previously shown to play a role in cellular metabolic reprogramming. We report that the suppression of ATM...

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Detalles Bibliográficos
Autores principales: Huang, Zhentai, Chen, Chi-Wei, Buj, Raquel, Tangudu, Naveen Kumar, Fang, Richard S., Leon, Kelly E., Dahl, Erika S., Varner, Erika L., von Krusenstiern, Eliana, Cole, Aidan R., Snyder, Nathaniel W., Aird, Katherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679964/
https://www.ncbi.nlm.nih.gov/pubmed/36399181
http://dx.doi.org/10.1083/jcb.202007026

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