Fusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3

[Image: see text] The cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein found overexpressed in many types of cancer. CIP2A has been shown to stabilize oncoproteins such as cMYC by shielding them from PP2A-mediated dephosphorylation. Here we report that the penultimate residue S...

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Detalles Bibliográficos
Autores principales: Brink, Hendrik J., van Senten, Jeffrey R., De Vries-van Leeuwen, Ingrid J., da Costa Pereira, Daniel, Piersma, Sander R., Jimenez, Connie R., Centorrino, Federica, Ottmann, Christian, Siderius, Marco, Smit, Martine J., de Boer, Albertus H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679992/
https://www.ncbi.nlm.nih.gov/pubmed/36255265
http://dx.doi.org/10.1021/acschembio.2c00299

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