Indolin-2-one Nitroimidazole Antibiotics Exhibit an Unexpected Dual Mode of Action

[Image: see text] Nitroimidazoles such as metronidazole are used as anti-infective drugs against anaerobic bacteria. Upon in vivo reduction of the nitro group, reactive radicals damage DNA and proteins in the absence of oxygen. Unexpectedly, a recent study of nitroimidazoles linked to an indolin-2-o...

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Detalles Bibliográficos
Autores principales: Reinhardt, Till, Lee, Kyu M., Niederegger, Lukas, Hess, Corinna R., Sieber, Stephan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679994/
https://www.ncbi.nlm.nih.gov/pubmed/36259427
http://dx.doi.org/10.1021/acschembio.2c00462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679994/
https://www.ncbi.nlm.nih.gov/pubmed/36259427
http://dx.doi.org/10.1021/acschembio.2c00462

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