A Chemical Biological Approach to Study G Protein-Coupled Receptors: Labeling the Adenosine A(1) Receptor Using an Electrophilic Covalent Probe

[Image: see text] G protein-coupled receptors (GPCRs) have been known for decades as attractive drug targets. This has led to the development and approval of many ligands targeting GPCRs. Although ligand binding effects have been studied thoroughly for many GPCRs, there are multiple aspects of GPCR...

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Autores principales: Beerkens, Bert L. H., Koç, Çağla, Liu, Rongfang, Florea, Bogdan I., Le Dévédec, Sylvia E., Heitman, Laura H., IJzerman, Adriaan P., van der Es, Daan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679998/
https://www.ncbi.nlm.nih.gov/pubmed/36279267
http://dx.doi.org/10.1021/acschembio.2c00589

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