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Mitochondrial connections with immune system in Zebrafish

Mitochondria are organelles commonly associated with adenosine triphosphate (ATP) formation through the oxidative phosphorylation (OXPHOS) process. However, mitochondria are also responsible for functions such as calcium homeostasis, apoptosis, autophagy, and production of reactive oxygen species (R...

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Autores principales: do Amaral, Mariana Abrantes, Paredes, Lais Cavalieri, Padovani, Barbara Nunes, Mendonça-Gomes, Juliana Moreira, Montes, Luan Fávero, Câmara, Niels Olsen Saraiva, Morales Fénero, Camila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680083/
https://www.ncbi.nlm.nih.gov/pubmed/36420514
http://dx.doi.org/10.1016/j.fsirep.2021.100019
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author do Amaral, Mariana Abrantes
Paredes, Lais Cavalieri
Padovani, Barbara Nunes
Mendonça-Gomes, Juliana Moreira
Montes, Luan Fávero
Câmara, Niels Olsen Saraiva
Morales Fénero, Camila
author_facet do Amaral, Mariana Abrantes
Paredes, Lais Cavalieri
Padovani, Barbara Nunes
Mendonça-Gomes, Juliana Moreira
Montes, Luan Fávero
Câmara, Niels Olsen Saraiva
Morales Fénero, Camila
author_sort do Amaral, Mariana Abrantes
collection PubMed
description Mitochondria are organelles commonly associated with adenosine triphosphate (ATP) formation through the oxidative phosphorylation (OXPHOS) process. However, mitochondria are also responsible for functions such as calcium homeostasis, apoptosis, autophagy, and production of reactive oxygen species (ROS) that, in conjunction, can lead to different cell fate decisions. Mitochondrial morphology changes rely on nutrients’ availability and the bioenergetics demands of the cells, in a process known as mitochondrial dynamics, which includes both fusion and fission. This organelle senses the microenvironment and can modify the cells to either a pro or anti-inflammatory profile. The zebrafish has been increasingly used to research mitochondrial dynamics and its connection with the immune system since the pathways and molecules involved in these processes are conserved on this fish. Several genetic tools and technologies are currently available to analyze the behavior of mitochondria in zebrafish. However, even though zebrafish presents several similar processes known in mammals, the effect of the mitochondria in the immune system has not been so broadly studied in this model. In this review, we summarize the current knowledge in zebrafish studies regarding mitochondrial function and immuno metabolism.
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spelling pubmed-96800832022-11-22 Mitochondrial connections with immune system in Zebrafish do Amaral, Mariana Abrantes Paredes, Lais Cavalieri Padovani, Barbara Nunes Mendonça-Gomes, Juliana Moreira Montes, Luan Fávero Câmara, Niels Olsen Saraiva Morales Fénero, Camila Fish Shellfish Immunol Rep Article Mitochondria are organelles commonly associated with adenosine triphosphate (ATP) formation through the oxidative phosphorylation (OXPHOS) process. However, mitochondria are also responsible for functions such as calcium homeostasis, apoptosis, autophagy, and production of reactive oxygen species (ROS) that, in conjunction, can lead to different cell fate decisions. Mitochondrial morphology changes rely on nutrients’ availability and the bioenergetics demands of the cells, in a process known as mitochondrial dynamics, which includes both fusion and fission. This organelle senses the microenvironment and can modify the cells to either a pro or anti-inflammatory profile. The zebrafish has been increasingly used to research mitochondrial dynamics and its connection with the immune system since the pathways and molecules involved in these processes are conserved on this fish. Several genetic tools and technologies are currently available to analyze the behavior of mitochondria in zebrafish. However, even though zebrafish presents several similar processes known in mammals, the effect of the mitochondria in the immune system has not been so broadly studied in this model. In this review, we summarize the current knowledge in zebrafish studies regarding mitochondrial function and immuno metabolism. Elsevier 2021-08-14 /pmc/articles/PMC9680083/ /pubmed/36420514 http://dx.doi.org/10.1016/j.fsirep.2021.100019 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
do Amaral, Mariana Abrantes
Paredes, Lais Cavalieri
Padovani, Barbara Nunes
Mendonça-Gomes, Juliana Moreira
Montes, Luan Fávero
Câmara, Niels Olsen Saraiva
Morales Fénero, Camila
Mitochondrial connections with immune system in Zebrafish
title Mitochondrial connections with immune system in Zebrafish
title_full Mitochondrial connections with immune system in Zebrafish
title_fullStr Mitochondrial connections with immune system in Zebrafish
title_full_unstemmed Mitochondrial connections with immune system in Zebrafish
title_short Mitochondrial connections with immune system in Zebrafish
title_sort mitochondrial connections with immune system in zebrafish
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680083/
https://www.ncbi.nlm.nih.gov/pubmed/36420514
http://dx.doi.org/10.1016/j.fsirep.2021.100019
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