Cargando…
A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment
Celiac disease (CD) is a common chronic inflammatory disorder occurring in genetically predisposed individuals secondary to gluten ingestion. CD usually presents with gastrointestinal symptoms such as pain, bloating, flatulence, and constipation or diarrhea. However, individuals can present in a non...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680226/ https://www.ncbi.nlm.nih.gov/pubmed/36412605 http://dx.doi.org/10.3390/diseases10040111 |
_version_ | 1784834365551804416 |
---|---|
author | Gala, Dhir Scharf, Shelbie Kudlak, Megan Green, Christian Khowaja, Faisal Shah, Mili Kumar, Vikash Ullal, Gautam |
author_facet | Gala, Dhir Scharf, Shelbie Kudlak, Megan Green, Christian Khowaja, Faisal Shah, Mili Kumar, Vikash Ullal, Gautam |
author_sort | Gala, Dhir |
collection | PubMed |
description | Celiac disease (CD) is a common chronic inflammatory disorder occurring in genetically predisposed individuals secondary to gluten ingestion. CD usually presents with gastrointestinal symptoms such as pain, bloating, flatulence, and constipation or diarrhea. However, individuals can present in a nonclassical manner with only extraintestinal symptoms. The neurological manifestations of CD include ataxia, cognitive impairment, epilepsy, headache, and neuropathy. A lifelong gluten-free diet is the current recommended treatment for CD. This review discusses the relevant neurological manifestations associated with CD and the novel therapeutics. Further research is required to get a better understanding of the underlying pathophysiology of the neurological manifestations associated with CD. Clinicians should keep CD in the differential diagnosis in individuals presenting with neurological dysfunction of unknown cause. |
format | Online Article Text |
id | pubmed-9680226 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96802262022-11-23 A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment Gala, Dhir Scharf, Shelbie Kudlak, Megan Green, Christian Khowaja, Faisal Shah, Mili Kumar, Vikash Ullal, Gautam Diseases Review Celiac disease (CD) is a common chronic inflammatory disorder occurring in genetically predisposed individuals secondary to gluten ingestion. CD usually presents with gastrointestinal symptoms such as pain, bloating, flatulence, and constipation or diarrhea. However, individuals can present in a nonclassical manner with only extraintestinal symptoms. The neurological manifestations of CD include ataxia, cognitive impairment, epilepsy, headache, and neuropathy. A lifelong gluten-free diet is the current recommended treatment for CD. This review discusses the relevant neurological manifestations associated with CD and the novel therapeutics. Further research is required to get a better understanding of the underlying pathophysiology of the neurological manifestations associated with CD. Clinicians should keep CD in the differential diagnosis in individuals presenting with neurological dysfunction of unknown cause. MDPI 2022-11-21 /pmc/articles/PMC9680226/ /pubmed/36412605 http://dx.doi.org/10.3390/diseases10040111 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gala, Dhir Scharf, Shelbie Kudlak, Megan Green, Christian Khowaja, Faisal Shah, Mili Kumar, Vikash Ullal, Gautam A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment |
title | A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment |
title_full | A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment |
title_fullStr | A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment |
title_full_unstemmed | A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment |
title_short | A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment |
title_sort | comprehensive review of the neurological manifestations of celiac disease and its treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680226/ https://www.ncbi.nlm.nih.gov/pubmed/36412605 http://dx.doi.org/10.3390/diseases10040111 |
work_keys_str_mv | AT galadhir acomprehensivereviewoftheneurologicalmanifestationsofceliacdiseaseanditstreatment AT scharfshelbie acomprehensivereviewoftheneurologicalmanifestationsofceliacdiseaseanditstreatment AT kudlakmegan acomprehensivereviewoftheneurologicalmanifestationsofceliacdiseaseanditstreatment AT greenchristian acomprehensivereviewoftheneurologicalmanifestationsofceliacdiseaseanditstreatment AT khowajafaisal acomprehensivereviewoftheneurologicalmanifestationsofceliacdiseaseanditstreatment AT shahmili acomprehensivereviewoftheneurologicalmanifestationsofceliacdiseaseanditstreatment AT kumarvikash acomprehensivereviewoftheneurologicalmanifestationsofceliacdiseaseanditstreatment AT ullalgautam acomprehensivereviewoftheneurologicalmanifestationsofceliacdiseaseanditstreatment AT galadhir comprehensivereviewoftheneurologicalmanifestationsofceliacdiseaseanditstreatment AT scharfshelbie comprehensivereviewoftheneurologicalmanifestationsofceliacdiseaseanditstreatment AT kudlakmegan comprehensivereviewoftheneurologicalmanifestationsofceliacdiseaseanditstreatment AT greenchristian comprehensivereviewoftheneurologicalmanifestationsofceliacdiseaseanditstreatment AT khowajafaisal comprehensivereviewoftheneurologicalmanifestationsofceliacdiseaseanditstreatment AT shahmili comprehensivereviewoftheneurologicalmanifestationsofceliacdiseaseanditstreatment AT kumarvikash comprehensivereviewoftheneurologicalmanifestationsofceliacdiseaseanditstreatment AT ullalgautam comprehensivereviewoftheneurologicalmanifestationsofceliacdiseaseanditstreatment |