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A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment

Celiac disease (CD) is a common chronic inflammatory disorder occurring in genetically predisposed individuals secondary to gluten ingestion. CD usually presents with gastrointestinal symptoms such as pain, bloating, flatulence, and constipation or diarrhea. However, individuals can present in a non...

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Autores principales: Gala, Dhir, Scharf, Shelbie, Kudlak, Megan, Green, Christian, Khowaja, Faisal, Shah, Mili, Kumar, Vikash, Ullal, Gautam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680226/
https://www.ncbi.nlm.nih.gov/pubmed/36412605
http://dx.doi.org/10.3390/diseases10040111
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author Gala, Dhir
Scharf, Shelbie
Kudlak, Megan
Green, Christian
Khowaja, Faisal
Shah, Mili
Kumar, Vikash
Ullal, Gautam
author_facet Gala, Dhir
Scharf, Shelbie
Kudlak, Megan
Green, Christian
Khowaja, Faisal
Shah, Mili
Kumar, Vikash
Ullal, Gautam
author_sort Gala, Dhir
collection PubMed
description Celiac disease (CD) is a common chronic inflammatory disorder occurring in genetically predisposed individuals secondary to gluten ingestion. CD usually presents with gastrointestinal symptoms such as pain, bloating, flatulence, and constipation or diarrhea. However, individuals can present in a nonclassical manner with only extraintestinal symptoms. The neurological manifestations of CD include ataxia, cognitive impairment, epilepsy, headache, and neuropathy. A lifelong gluten-free diet is the current recommended treatment for CD. This review discusses the relevant neurological manifestations associated with CD and the novel therapeutics. Further research is required to get a better understanding of the underlying pathophysiology of the neurological manifestations associated with CD. Clinicians should keep CD in the differential diagnosis in individuals presenting with neurological dysfunction of unknown cause.
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spelling pubmed-96802262022-11-23 A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment Gala, Dhir Scharf, Shelbie Kudlak, Megan Green, Christian Khowaja, Faisal Shah, Mili Kumar, Vikash Ullal, Gautam Diseases Review Celiac disease (CD) is a common chronic inflammatory disorder occurring in genetically predisposed individuals secondary to gluten ingestion. CD usually presents with gastrointestinal symptoms such as pain, bloating, flatulence, and constipation or diarrhea. However, individuals can present in a nonclassical manner with only extraintestinal symptoms. The neurological manifestations of CD include ataxia, cognitive impairment, epilepsy, headache, and neuropathy. A lifelong gluten-free diet is the current recommended treatment for CD. This review discusses the relevant neurological manifestations associated with CD and the novel therapeutics. Further research is required to get a better understanding of the underlying pathophysiology of the neurological manifestations associated with CD. Clinicians should keep CD in the differential diagnosis in individuals presenting with neurological dysfunction of unknown cause. MDPI 2022-11-21 /pmc/articles/PMC9680226/ /pubmed/36412605 http://dx.doi.org/10.3390/diseases10040111 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gala, Dhir
Scharf, Shelbie
Kudlak, Megan
Green, Christian
Khowaja, Faisal
Shah, Mili
Kumar, Vikash
Ullal, Gautam
A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment
title A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment
title_full A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment
title_fullStr A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment
title_full_unstemmed A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment
title_short A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment
title_sort comprehensive review of the neurological manifestations of celiac disease and its treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680226/
https://www.ncbi.nlm.nih.gov/pubmed/36412605
http://dx.doi.org/10.3390/diseases10040111
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