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Identification of Differentially Expressed Intronic Transcripts in Osteosarcoma
Over the past decade; the discovery and characterization of long noncoding RNAs (lncRNAs) have revealed that they play a major role in the development of various diseases; including cancer. Intronic transcripts are one of the most fascinating lncRNAs that are located within intron regions of protein...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680297/ https://www.ncbi.nlm.nih.gov/pubmed/36412907 http://dx.doi.org/10.3390/ncrna8060073 |
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author | Rothzerg, Emel Xu, Jiake Wood, David |
author_facet | Rothzerg, Emel Xu, Jiake Wood, David |
author_sort | Rothzerg, Emel |
collection | PubMed |
description | Over the past decade; the discovery and characterization of long noncoding RNAs (lncRNAs) have revealed that they play a major role in the development of various diseases; including cancer. Intronic transcripts are one of the most fascinating lncRNAs that are located within intron regions of protein-coding genes, which have the advantage of encoding micropeptides. There have been several studies looking at intronic transcript expression profiles in cancer; but almost none in osteosarcoma. To overcome this problem; we have investigated differentially expressed intronic transcripts between osteosarcoma and normal bone tissues. The results highlighted that NRG1-IT1; FGF14-IT1; and HAO2-IT1 were downregulated; whereas ER3-IT1; SND1-IT1; ANKRD44-IT1; AGAP1-IT1; DIP2A-IT1; LMO7DN-IT1; SLIT2-IT1; RNF216-IT1; and TCF7L1-IT1 were upregulated in osteosarcoma tissues compared to normal bone tissues. Furthermore, we identified if the transcripts encode micropeptides and the transcripts’ locations in a cell. |
format | Online Article Text |
id | pubmed-9680297 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96802972022-11-23 Identification of Differentially Expressed Intronic Transcripts in Osteosarcoma Rothzerg, Emel Xu, Jiake Wood, David Noncoding RNA Article Over the past decade; the discovery and characterization of long noncoding RNAs (lncRNAs) have revealed that they play a major role in the development of various diseases; including cancer. Intronic transcripts are one of the most fascinating lncRNAs that are located within intron regions of protein-coding genes, which have the advantage of encoding micropeptides. There have been several studies looking at intronic transcript expression profiles in cancer; but almost none in osteosarcoma. To overcome this problem; we have investigated differentially expressed intronic transcripts between osteosarcoma and normal bone tissues. The results highlighted that NRG1-IT1; FGF14-IT1; and HAO2-IT1 were downregulated; whereas ER3-IT1; SND1-IT1; ANKRD44-IT1; AGAP1-IT1; DIP2A-IT1; LMO7DN-IT1; SLIT2-IT1; RNF216-IT1; and TCF7L1-IT1 were upregulated in osteosarcoma tissues compared to normal bone tissues. Furthermore, we identified if the transcripts encode micropeptides and the transcripts’ locations in a cell. MDPI 2022-10-25 /pmc/articles/PMC9680297/ /pubmed/36412907 http://dx.doi.org/10.3390/ncrna8060073 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rothzerg, Emel Xu, Jiake Wood, David Identification of Differentially Expressed Intronic Transcripts in Osteosarcoma |
title | Identification of Differentially Expressed Intronic Transcripts in Osteosarcoma |
title_full | Identification of Differentially Expressed Intronic Transcripts in Osteosarcoma |
title_fullStr | Identification of Differentially Expressed Intronic Transcripts in Osteosarcoma |
title_full_unstemmed | Identification of Differentially Expressed Intronic Transcripts in Osteosarcoma |
title_short | Identification of Differentially Expressed Intronic Transcripts in Osteosarcoma |
title_sort | identification of differentially expressed intronic transcripts in osteosarcoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680297/ https://www.ncbi.nlm.nih.gov/pubmed/36412907 http://dx.doi.org/10.3390/ncrna8060073 |
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