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Salivary Biomarkers in Oral Squamous Cell Carcinoma: A Proteomic Overview

Background: Oral squamous cell carcinoma (OSCC) is one of the most frequent cancers worldwide. Endoscopic methods may be useful in the evaluation of oral injuries even though the diagnostic gold standard is a biopsy. Targeted screenings could be considered the best way to prevent the occurrence of o...

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Autores principales: Riccardi, Gabriele, Bellizzi, Mario Giuseppe, Fatuzzo, Irene, Zoccali, Federica, Cavalcanti, Luca, Greco, Antonio, de Vincentiis, Marco, Ralli, Massimo, Fiore, Marco, Petrella, Carla, Minni, Antonio, Barbato, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680331/
https://www.ncbi.nlm.nih.gov/pubmed/36412636
http://dx.doi.org/10.3390/proteomes10040037
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author Riccardi, Gabriele
Bellizzi, Mario Giuseppe
Fatuzzo, Irene
Zoccali, Federica
Cavalcanti, Luca
Greco, Antonio
de Vincentiis, Marco
Ralli, Massimo
Fiore, Marco
Petrella, Carla
Minni, Antonio
Barbato, Christian
author_facet Riccardi, Gabriele
Bellizzi, Mario Giuseppe
Fatuzzo, Irene
Zoccali, Federica
Cavalcanti, Luca
Greco, Antonio
de Vincentiis, Marco
Ralli, Massimo
Fiore, Marco
Petrella, Carla
Minni, Antonio
Barbato, Christian
author_sort Riccardi, Gabriele
collection PubMed
description Background: Oral squamous cell carcinoma (OSCC) is one of the most frequent cancers worldwide. Endoscopic methods may be useful in the evaluation of oral injuries even though the diagnostic gold standard is a biopsy. Targeted screenings could be considered the best way to prevent the occurrence of oral cancer. Aimed to elucidate the potential identification of specific biomarkers of OSCC, the use of saliva is convenient and noninvasive. Many studies reported more than a hundred putative saliva biomarkers for OSCC, and proteogenomic approaches were fundamental to disclosing this issue. Methods: Relevant literature published in the last few years was systematically searched on PubMed and we focused on articles about the use and study of salivary biomarkers in the diagnostics of head and neck cancer (n = 110). Thereafter, we performed a selection focusing on diagnosis with salivary proteomics in OSCC (n = 8). Results: Saliva proteomics can be a source of biomarkers for OSCC. We reviewed literature of biomarker proteins in saliva that could also be evaluated as probable targets for non-invasive screening of oral neoplasm such as cytokines, matrix metalloproteinases, and acute-phase response proteins. Conclusions: The measurement of salivary biomarkers is a highly hopeful technique for the diagnosis of OSCC. Proteogenomic approaches could permit an accurate and early diagnosis of OSCC. This review seeks to generate an up-to-date view on translational OSCC issues by raising awareness of researchers, physicians, and surgeons. Renewed clinical studies, which will validate the sensitivity and specificity of salivary biomarkers, are necessary to translate these results into possible strategies for early diagnosis of OSCC, thus improving patient outcomes.
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spelling pubmed-96803312022-11-23 Salivary Biomarkers in Oral Squamous Cell Carcinoma: A Proteomic Overview Riccardi, Gabriele Bellizzi, Mario Giuseppe Fatuzzo, Irene Zoccali, Federica Cavalcanti, Luca Greco, Antonio de Vincentiis, Marco Ralli, Massimo Fiore, Marco Petrella, Carla Minni, Antonio Barbato, Christian Proteomes Review Background: Oral squamous cell carcinoma (OSCC) is one of the most frequent cancers worldwide. Endoscopic methods may be useful in the evaluation of oral injuries even though the diagnostic gold standard is a biopsy. Targeted screenings could be considered the best way to prevent the occurrence of oral cancer. Aimed to elucidate the potential identification of specific biomarkers of OSCC, the use of saliva is convenient and noninvasive. Many studies reported more than a hundred putative saliva biomarkers for OSCC, and proteogenomic approaches were fundamental to disclosing this issue. Methods: Relevant literature published in the last few years was systematically searched on PubMed and we focused on articles about the use and study of salivary biomarkers in the diagnostics of head and neck cancer (n = 110). Thereafter, we performed a selection focusing on diagnosis with salivary proteomics in OSCC (n = 8). Results: Saliva proteomics can be a source of biomarkers for OSCC. We reviewed literature of biomarker proteins in saliva that could also be evaluated as probable targets for non-invasive screening of oral neoplasm such as cytokines, matrix metalloproteinases, and acute-phase response proteins. Conclusions: The measurement of salivary biomarkers is a highly hopeful technique for the diagnosis of OSCC. Proteogenomic approaches could permit an accurate and early diagnosis of OSCC. This review seeks to generate an up-to-date view on translational OSCC issues by raising awareness of researchers, physicians, and surgeons. Renewed clinical studies, which will validate the sensitivity and specificity of salivary biomarkers, are necessary to translate these results into possible strategies for early diagnosis of OSCC, thus improving patient outcomes. MDPI 2022-11-07 /pmc/articles/PMC9680331/ /pubmed/36412636 http://dx.doi.org/10.3390/proteomes10040037 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Riccardi, Gabriele
Bellizzi, Mario Giuseppe
Fatuzzo, Irene
Zoccali, Federica
Cavalcanti, Luca
Greco, Antonio
de Vincentiis, Marco
Ralli, Massimo
Fiore, Marco
Petrella, Carla
Minni, Antonio
Barbato, Christian
Salivary Biomarkers in Oral Squamous Cell Carcinoma: A Proteomic Overview
title Salivary Biomarkers in Oral Squamous Cell Carcinoma: A Proteomic Overview
title_full Salivary Biomarkers in Oral Squamous Cell Carcinoma: A Proteomic Overview
title_fullStr Salivary Biomarkers in Oral Squamous Cell Carcinoma: A Proteomic Overview
title_full_unstemmed Salivary Biomarkers in Oral Squamous Cell Carcinoma: A Proteomic Overview
title_short Salivary Biomarkers in Oral Squamous Cell Carcinoma: A Proteomic Overview
title_sort salivary biomarkers in oral squamous cell carcinoma: a proteomic overview
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680331/
https://www.ncbi.nlm.nih.gov/pubmed/36412636
http://dx.doi.org/10.3390/proteomes10040037
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