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Rapid Progression of COVID-19-Associated Fatal Capillary Leak Syndrome

Several cases of capillary leak syndrome (CLS) related to COVID-19 or vaccination against SARS-CoV-2 have been described in the literature. We present a case of a 42-year-old, previously healthy male, presenting with a mild form of COVID-19, who suddenly developed severe shock with hypotension and s...

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Autores principales: Novotná, Eva, Filipová, Pavlína, Vonke, Ivan, Kuta, Bohuslav, Chrdle, Aleš
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680370/
https://www.ncbi.nlm.nih.gov/pubmed/36412746
http://dx.doi.org/10.3390/idr14060088
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author Novotná, Eva
Filipová, Pavlína
Vonke, Ivan
Kuta, Bohuslav
Chrdle, Aleš
author_facet Novotná, Eva
Filipová, Pavlína
Vonke, Ivan
Kuta, Bohuslav
Chrdle, Aleš
author_sort Novotná, Eva
collection PubMed
description Several cases of capillary leak syndrome (CLS) related to COVID-19 or vaccination against SARS-CoV-2 have been described in the literature. We present a case of a 42-year-old, previously healthy male, presenting with a mild form of COVID-19, who suddenly developed severe shock with hypotension and severe hemoconcentration within hours of admission to the hospital. Volume resuscitation was not effective, increasing hemoglobin (198 g/L on admission, 222 g/L 9 h later) suggested fluid leak into peripheral tissues. After cardiac arrest, the patient was resuscitated and connected to extracorporeal membrane oxygenation, but died shortly afterwards due to refractory heart failure. Retrospective investigation of blood samples confirmed diagnosis of CLS by progressive hypoalbuminemia (40 g/L on admission, 14 g/L 19 h later) and monoclonal gammopathy kappa (4.7 g/L). Patient’s CLS was triggered by COVID-19, either a first attack of idiopathic CLS called Clarkson’s disease or a COVID-19-induced secondary CLS.
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spelling pubmed-96803702022-11-23 Rapid Progression of COVID-19-Associated Fatal Capillary Leak Syndrome Novotná, Eva Filipová, Pavlína Vonke, Ivan Kuta, Bohuslav Chrdle, Aleš Infect Dis Rep Case Report Several cases of capillary leak syndrome (CLS) related to COVID-19 or vaccination against SARS-CoV-2 have been described in the literature. We present a case of a 42-year-old, previously healthy male, presenting with a mild form of COVID-19, who suddenly developed severe shock with hypotension and severe hemoconcentration within hours of admission to the hospital. Volume resuscitation was not effective, increasing hemoglobin (198 g/L on admission, 222 g/L 9 h later) suggested fluid leak into peripheral tissues. After cardiac arrest, the patient was resuscitated and connected to extracorporeal membrane oxygenation, but died shortly afterwards due to refractory heart failure. Retrospective investigation of blood samples confirmed diagnosis of CLS by progressive hypoalbuminemia (40 g/L on admission, 14 g/L 19 h later) and monoclonal gammopathy kappa (4.7 g/L). Patient’s CLS was triggered by COVID-19, either a first attack of idiopathic CLS called Clarkson’s disease or a COVID-19-induced secondary CLS. MDPI 2022-11-17 /pmc/articles/PMC9680370/ /pubmed/36412746 http://dx.doi.org/10.3390/idr14060088 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Novotná, Eva
Filipová, Pavlína
Vonke, Ivan
Kuta, Bohuslav
Chrdle, Aleš
Rapid Progression of COVID-19-Associated Fatal Capillary Leak Syndrome
title Rapid Progression of COVID-19-Associated Fatal Capillary Leak Syndrome
title_full Rapid Progression of COVID-19-Associated Fatal Capillary Leak Syndrome
title_fullStr Rapid Progression of COVID-19-Associated Fatal Capillary Leak Syndrome
title_full_unstemmed Rapid Progression of COVID-19-Associated Fatal Capillary Leak Syndrome
title_short Rapid Progression of COVID-19-Associated Fatal Capillary Leak Syndrome
title_sort rapid progression of covid-19-associated fatal capillary leak syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680370/
https://www.ncbi.nlm.nih.gov/pubmed/36412746
http://dx.doi.org/10.3390/idr14060088
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