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Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chattogram Metropolitan Area, Bangladesh

Seroprevalence studies of COVID-19 are used to assess the degree of undetected transmission in the community and different groups such as health care workers (HCWs) are deemed vulnerable due to their workplace hazards. The present study estimated the seroprevalence and quantified the titer of anti-S...

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Autores principales: Ara, Jahan, Islam, Md. Sirazul, Quader, Md. Tarek Ul, Das, Anan, Hasib, F. M. Yasir, Islam, Mohammad Saiful, Rahman, Tazrina, Das, Seemanta, Chowdhury, M. A. Hassan, Das, Goutam Buddha, Chowdhury, Sharmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680400/
https://www.ncbi.nlm.nih.gov/pubmed/36412835
http://dx.doi.org/10.3390/antib11040069
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author Ara, Jahan
Islam, Md. Sirazul
Quader, Md. Tarek Ul
Das, Anan
Hasib, F. M. Yasir
Islam, Mohammad Saiful
Rahman, Tazrina
Das, Seemanta
Chowdhury, M. A. Hassan
Das, Goutam Buddha
Chowdhury, Sharmin
author_facet Ara, Jahan
Islam, Md. Sirazul
Quader, Md. Tarek Ul
Das, Anan
Hasib, F. M. Yasir
Islam, Mohammad Saiful
Rahman, Tazrina
Das, Seemanta
Chowdhury, M. A. Hassan
Das, Goutam Buddha
Chowdhury, Sharmin
author_sort Ara, Jahan
collection PubMed
description Seroprevalence studies of COVID-19 are used to assess the degree of undetected transmission in the community and different groups such as health care workers (HCWs) are deemed vulnerable due to their workplace hazards. The present study estimated the seroprevalence and quantified the titer of anti-SARS-CoV-2 antibody (IgG) and its association with different factors. This cross-sectional study observed HCWs, in indoor and outdoor patients (non-COVID-19) and garment workers in the Chattogram metropolitan area (CMA, N = 748) from six hospitals and two garment factories. Qualitative and quantitative ELISA were used to identify and quantify antibodies (IgG) in the serum samples. Descriptive, univariable, and multivariable statistical analysis were performed. Overall seroprevalence and among HCWs, in indoor and outdoor patients, and garment workers were 66.99% (95% CI: 63.40–70.40%), 68.99% (95% CI: 63.8–73.7%), 81.37% (95% CI: 74.7–86.7%), and 50.56% (95% CI: 43.5–57.5%), respectively. Seroprevalence and mean titer was 44.47% (95% CI: 38.6–50.4%) and 53.71 DU/mL in the non-vaccinated population, respectively, while it was higher in the population who received a first dose (61.66%, 95% CI: 54.8–68.0%, 159.08 DU/mL) and both doses (100%, 95% CI: 98.4–100%, 255.46 DU/mL). This study emphasizes the role of vaccine in antibody production; the second dose of vaccine significantly increased the seroprevalence and titer and both were low in natural infection.
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spelling pubmed-96804002022-11-23 Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chattogram Metropolitan Area, Bangladesh Ara, Jahan Islam, Md. Sirazul Quader, Md. Tarek Ul Das, Anan Hasib, F. M. Yasir Islam, Mohammad Saiful Rahman, Tazrina Das, Seemanta Chowdhury, M. A. Hassan Das, Goutam Buddha Chowdhury, Sharmin Antibodies (Basel) Article Seroprevalence studies of COVID-19 are used to assess the degree of undetected transmission in the community and different groups such as health care workers (HCWs) are deemed vulnerable due to their workplace hazards. The present study estimated the seroprevalence and quantified the titer of anti-SARS-CoV-2 antibody (IgG) and its association with different factors. This cross-sectional study observed HCWs, in indoor and outdoor patients (non-COVID-19) and garment workers in the Chattogram metropolitan area (CMA, N = 748) from six hospitals and two garment factories. Qualitative and quantitative ELISA were used to identify and quantify antibodies (IgG) in the serum samples. Descriptive, univariable, and multivariable statistical analysis were performed. Overall seroprevalence and among HCWs, in indoor and outdoor patients, and garment workers were 66.99% (95% CI: 63.40–70.40%), 68.99% (95% CI: 63.8–73.7%), 81.37% (95% CI: 74.7–86.7%), and 50.56% (95% CI: 43.5–57.5%), respectively. Seroprevalence and mean titer was 44.47% (95% CI: 38.6–50.4%) and 53.71 DU/mL in the non-vaccinated population, respectively, while it was higher in the population who received a first dose (61.66%, 95% CI: 54.8–68.0%, 159.08 DU/mL) and both doses (100%, 95% CI: 98.4–100%, 255.46 DU/mL). This study emphasizes the role of vaccine in antibody production; the second dose of vaccine significantly increased the seroprevalence and titer and both were low in natural infection. MDPI 2022-11-07 /pmc/articles/PMC9680400/ /pubmed/36412835 http://dx.doi.org/10.3390/antib11040069 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ara, Jahan
Islam, Md. Sirazul
Quader, Md. Tarek Ul
Das, Anan
Hasib, F. M. Yasir
Islam, Mohammad Saiful
Rahman, Tazrina
Das, Seemanta
Chowdhury, M. A. Hassan
Das, Goutam Buddha
Chowdhury, Sharmin
Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chattogram Metropolitan Area, Bangladesh
title Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chattogram Metropolitan Area, Bangladesh
title_full Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chattogram Metropolitan Area, Bangladesh
title_fullStr Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chattogram Metropolitan Area, Bangladesh
title_full_unstemmed Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chattogram Metropolitan Area, Bangladesh
title_short Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chattogram Metropolitan Area, Bangladesh
title_sort seroprevalence of anti-sars-cov-2 antibodies in chattogram metropolitan area, bangladesh
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680400/
https://www.ncbi.nlm.nih.gov/pubmed/36412835
http://dx.doi.org/10.3390/antib11040069
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