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Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish

Organophosphate (OP) insecticides are used to eliminate agricultural threats posed by insects, through inhibition of the neurotransmitter acetylcholinesterase (AChE). These potent neurotoxins are extremely efficacious in insect elimination, and as such, are the preferred agricultural insecticides wo...

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Autores principales: Neylon, Jeremy, Fuller, Jarrad N., van der Poel, Chris, Church, Jarrod E., Dworkin, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680476/
https://www.ncbi.nlm.nih.gov/pubmed/36412643
http://dx.doi.org/10.3390/jdb10040049
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author Neylon, Jeremy
Fuller, Jarrad N.
van der Poel, Chris
Church, Jarrod E.
Dworkin, Sebastian
author_facet Neylon, Jeremy
Fuller, Jarrad N.
van der Poel, Chris
Church, Jarrod E.
Dworkin, Sebastian
author_sort Neylon, Jeremy
collection PubMed
description Organophosphate (OP) insecticides are used to eliminate agricultural threats posed by insects, through inhibition of the neurotransmitter acetylcholinesterase (AChE). These potent neurotoxins are extremely efficacious in insect elimination, and as such, are the preferred agricultural insecticides worldwide. Despite their efficacy, however, estimates indicate that only 0.1% of organophosphates reach their desired target. Moreover, multiple studies have shown that OP exposure in both humans and animals can lead to aberrations in embryonic development, defects in childhood neurocognition, and substantial contribution to neurodegenerative diseases such as Alzheimer’s and Motor Neurone Disease. Here, we review the current state of knowledge pertaining to organophosphate exposure on both embryonic development and/or subsequent neurological consequences on behaviour, paying particular attention to data gleaned using an excellent animal model, the zebrafish (Danio rerio).
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spelling pubmed-96804762022-11-23 Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish Neylon, Jeremy Fuller, Jarrad N. van der Poel, Chris Church, Jarrod E. Dworkin, Sebastian J Dev Biol Review Organophosphate (OP) insecticides are used to eliminate agricultural threats posed by insects, through inhibition of the neurotransmitter acetylcholinesterase (AChE). These potent neurotoxins are extremely efficacious in insect elimination, and as such, are the preferred agricultural insecticides worldwide. Despite their efficacy, however, estimates indicate that only 0.1% of organophosphates reach their desired target. Moreover, multiple studies have shown that OP exposure in both humans and animals can lead to aberrations in embryonic development, defects in childhood neurocognition, and substantial contribution to neurodegenerative diseases such as Alzheimer’s and Motor Neurone Disease. Here, we review the current state of knowledge pertaining to organophosphate exposure on both embryonic development and/or subsequent neurological consequences on behaviour, paying particular attention to data gleaned using an excellent animal model, the zebrafish (Danio rerio). MDPI 2022-11-21 /pmc/articles/PMC9680476/ /pubmed/36412643 http://dx.doi.org/10.3390/jdb10040049 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Neylon, Jeremy
Fuller, Jarrad N.
van der Poel, Chris
Church, Jarrod E.
Dworkin, Sebastian
Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish
title Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish
title_full Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish
title_fullStr Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish
title_full_unstemmed Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish
title_short Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish
title_sort organophosphate insecticide toxicity in neural development, cognition, behaviour and degeneration: insights from zebrafish
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680476/
https://www.ncbi.nlm.nih.gov/pubmed/36412643
http://dx.doi.org/10.3390/jdb10040049
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