Cargando…
Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish
Organophosphate (OP) insecticides are used to eliminate agricultural threats posed by insects, through inhibition of the neurotransmitter acetylcholinesterase (AChE). These potent neurotoxins are extremely efficacious in insect elimination, and as such, are the preferred agricultural insecticides wo...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680476/ https://www.ncbi.nlm.nih.gov/pubmed/36412643 http://dx.doi.org/10.3390/jdb10040049 |
_version_ | 1784834427260502016 |
---|---|
author | Neylon, Jeremy Fuller, Jarrad N. van der Poel, Chris Church, Jarrod E. Dworkin, Sebastian |
author_facet | Neylon, Jeremy Fuller, Jarrad N. van der Poel, Chris Church, Jarrod E. Dworkin, Sebastian |
author_sort | Neylon, Jeremy |
collection | PubMed |
description | Organophosphate (OP) insecticides are used to eliminate agricultural threats posed by insects, through inhibition of the neurotransmitter acetylcholinesterase (AChE). These potent neurotoxins are extremely efficacious in insect elimination, and as such, are the preferred agricultural insecticides worldwide. Despite their efficacy, however, estimates indicate that only 0.1% of organophosphates reach their desired target. Moreover, multiple studies have shown that OP exposure in both humans and animals can lead to aberrations in embryonic development, defects in childhood neurocognition, and substantial contribution to neurodegenerative diseases such as Alzheimer’s and Motor Neurone Disease. Here, we review the current state of knowledge pertaining to organophosphate exposure on both embryonic development and/or subsequent neurological consequences on behaviour, paying particular attention to data gleaned using an excellent animal model, the zebrafish (Danio rerio). |
format | Online Article Text |
id | pubmed-9680476 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96804762022-11-23 Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish Neylon, Jeremy Fuller, Jarrad N. van der Poel, Chris Church, Jarrod E. Dworkin, Sebastian J Dev Biol Review Organophosphate (OP) insecticides are used to eliminate agricultural threats posed by insects, through inhibition of the neurotransmitter acetylcholinesterase (AChE). These potent neurotoxins are extremely efficacious in insect elimination, and as such, are the preferred agricultural insecticides worldwide. Despite their efficacy, however, estimates indicate that only 0.1% of organophosphates reach their desired target. Moreover, multiple studies have shown that OP exposure in both humans and animals can lead to aberrations in embryonic development, defects in childhood neurocognition, and substantial contribution to neurodegenerative diseases such as Alzheimer’s and Motor Neurone Disease. Here, we review the current state of knowledge pertaining to organophosphate exposure on both embryonic development and/or subsequent neurological consequences on behaviour, paying particular attention to data gleaned using an excellent animal model, the zebrafish (Danio rerio). MDPI 2022-11-21 /pmc/articles/PMC9680476/ /pubmed/36412643 http://dx.doi.org/10.3390/jdb10040049 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Neylon, Jeremy Fuller, Jarrad N. van der Poel, Chris Church, Jarrod E. Dworkin, Sebastian Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish |
title | Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish |
title_full | Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish |
title_fullStr | Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish |
title_full_unstemmed | Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish |
title_short | Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish |
title_sort | organophosphate insecticide toxicity in neural development, cognition, behaviour and degeneration: insights from zebrafish |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680476/ https://www.ncbi.nlm.nih.gov/pubmed/36412643 http://dx.doi.org/10.3390/jdb10040049 |
work_keys_str_mv | AT neylonjeremy organophosphateinsecticidetoxicityinneuraldevelopmentcognitionbehaviouranddegenerationinsightsfromzebrafish AT fullerjarradn organophosphateinsecticidetoxicityinneuraldevelopmentcognitionbehaviouranddegenerationinsightsfromzebrafish AT vanderpoelchris organophosphateinsecticidetoxicityinneuraldevelopmentcognitionbehaviouranddegenerationinsightsfromzebrafish AT churchjarrode organophosphateinsecticidetoxicityinneuraldevelopmentcognitionbehaviouranddegenerationinsightsfromzebrafish AT dworkinsebastian organophosphateinsecticidetoxicityinneuraldevelopmentcognitionbehaviouranddegenerationinsightsfromzebrafish |